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Gene: SIVA1 |
Gene summary for SIVA1 |
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Gene information | Species | Human | Gene symbol | SIVA1 | Gene ID | 10572 |
Gene name | SIVA1 apoptosis inducing factor | |
Gene Alias | CD27BP | |
Cytomap | 14q32.33 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | O15304 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10572 | SIVA1 | P10T-E | Human | Esophagus | ESCC | 1.56e-96 | 2.41e+00 | 0.116 |
10572 | SIVA1 | P11T-E | Human | Esophagus | ESCC | 3.58e-24 | 1.03e+00 | 0.1426 |
10572 | SIVA1 | P12T-E | Human | Esophagus | ESCC | 5.25e-94 | 1.97e+00 | 0.1122 |
10572 | SIVA1 | P15T-E | Human | Esophagus | ESCC | 3.42e-85 | 2.52e+00 | 0.1149 |
10572 | SIVA1 | P16T-E | Human | Esophagus | ESCC | 4.38e-57 | 1.30e+00 | 0.1153 |
10572 | SIVA1 | P17T-E | Human | Esophagus | ESCC | 5.22e-29 | 1.59e+00 | 0.1278 |
10572 | SIVA1 | P19T-E | Human | Esophagus | ESCC | 1.14e-14 | 1.64e+00 | 0.1662 |
10572 | SIVA1 | P20T-E | Human | Esophagus | ESCC | 2.24e-54 | 1.28e+00 | 0.1124 |
10572 | SIVA1 | P21T-E | Human | Esophagus | ESCC | 2.48e-80 | 1.86e+00 | 0.1617 |
10572 | SIVA1 | P22T-E | Human | Esophagus | ESCC | 2.98e-83 | 1.83e+00 | 0.1236 |
10572 | SIVA1 | P23T-E | Human | Esophagus | ESCC | 1.52e-60 | 1.56e+00 | 0.108 |
10572 | SIVA1 | P24T-E | Human | Esophagus | ESCC | 1.19e-44 | 1.34e+00 | 0.1287 |
10572 | SIVA1 | P26T-E | Human | Esophagus | ESCC | 4.30e-80 | 1.96e+00 | 0.1276 |
10572 | SIVA1 | P27T-E | Human | Esophagus | ESCC | 2.69e-96 | 2.06e+00 | 0.1055 |
10572 | SIVA1 | P28T-E | Human | Esophagus | ESCC | 1.95e-74 | 2.04e+00 | 0.1149 |
10572 | SIVA1 | P30T-E | Human | Esophagus | ESCC | 3.26e-44 | 2.02e+00 | 0.137 |
10572 | SIVA1 | P31T-E | Human | Esophagus | ESCC | 8.78e-92 | 2.14e+00 | 0.1251 |
10572 | SIVA1 | P32T-E | Human | Esophagus | ESCC | 3.06e-87 | 2.45e+00 | 0.1666 |
10572 | SIVA1 | P36T-E | Human | Esophagus | ESCC | 1.36e-35 | 1.46e+00 | 0.1187 |
10572 | SIVA1 | P37T-E | Human | Esophagus | ESCC | 4.67e-75 | 2.31e+00 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001603214 | Breast | IDC | viral process | 75/1434 | 415/18723 | 1.98e-12 | 4.02e-10 | 75 |
GO:001905814 | Breast | IDC | viral life cycle | 61/1434 | 317/18723 | 1.61e-11 | 2.77e-09 | 61 |
GO:004440314 | Breast | IDC | biological process involved in symbiotic interaction | 52/1434 | 290/18723 | 6.55e-09 | 5.03e-07 | 52 |
GO:009719114 | Breast | IDC | extrinsic apoptotic signaling pathway | 42/1434 | 219/18723 | 2.56e-08 | 1.73e-06 | 42 |
GO:005212614 | Breast | IDC | movement in host environment | 32/1434 | 175/18723 | 3.33e-06 | 1.22e-04 | 32 |
GO:005170114 | Breast | IDC | biological process involved in interaction with host | 35/1434 | 203/18723 | 4.72e-06 | 1.63e-04 | 35 |
GO:004440914 | Breast | IDC | entry into host | 28/1434 | 151/18723 | 1.02e-05 | 2.82e-04 | 28 |
GO:004671814 | Breast | IDC | viral entry into host cell | 27/1434 | 144/18723 | 1.18e-05 | 3.14e-04 | 27 |
GO:001603224 | Breast | DCIS | viral process | 73/1390 | 415/18723 | 3.40e-12 | 6.88e-10 | 73 |
GO:001905824 | Breast | DCIS | viral life cycle | 59/1390 | 317/18723 | 4.05e-11 | 5.74e-09 | 59 |
GO:004440323 | Breast | DCIS | biological process involved in symbiotic interaction | 49/1390 | 290/18723 | 4.70e-08 | 2.89e-06 | 49 |
GO:009719123 | Breast | DCIS | extrinsic apoptotic signaling pathway | 40/1390 | 219/18723 | 9.43e-08 | 5.28e-06 | 40 |
GO:005212624 | Breast | DCIS | movement in host environment | 31/1390 | 175/18723 | 4.93e-06 | 1.45e-04 | 31 |
GO:005170124 | Breast | DCIS | biological process involved in interaction with host | 34/1390 | 203/18723 | 6.30e-06 | 1.78e-04 | 34 |
GO:004440924 | Breast | DCIS | entry into host | 27/1390 | 151/18723 | 1.65e-05 | 4.00e-04 | 27 |
GO:004671824 | Breast | DCIS | viral entry into host cell | 26/1390 | 144/18723 | 1.97e-05 | 4.69e-04 | 26 |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041157 | Breast | IDC | p53 signaling pathway | 16/867 | 74/8465 | 2.86e-03 | 1.86e-02 | 1.39e-02 | 16 |
hsa0411512 | Breast | IDC | p53 signaling pathway | 16/867 | 74/8465 | 2.86e-03 | 1.86e-02 | 1.39e-02 | 16 |
hsa0411521 | Breast | DCIS | p53 signaling pathway | 16/846 | 74/8465 | 2.23e-03 | 1.47e-02 | 1.08e-02 | 16 |
hsa0411531 | Breast | DCIS | p53 signaling pathway | 16/846 | 74/8465 | 2.23e-03 | 1.47e-02 | 1.08e-02 | 16 |
hsa0411510 | Esophagus | HGIN | p53 signaling pathway | 21/1383 | 74/8465 | 6.25e-03 | 4.25e-02 | 3.37e-02 | 21 |
hsa0411515 | Esophagus | HGIN | p53 signaling pathway | 21/1383 | 74/8465 | 6.25e-03 | 4.25e-02 | 3.37e-02 | 21 |
hsa0411524 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa0411534 | Esophagus | ESCC | p53 signaling pathway | 65/4205 | 74/8465 | 3.88e-12 | 6.50e-11 | 3.33e-11 | 65 |
hsa041156 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa0411511 | Liver | HCC | p53 signaling pathway | 46/4020 | 74/8465 | 7.64e-03 | 2.08e-02 | 1.16e-02 | 46 |
hsa041159 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411514 | Oral cavity | OSCC | p53 signaling pathway | 57/3704 | 74/8465 | 4.99e-09 | 5.07e-08 | 2.58e-08 | 57 |
hsa0411523 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
hsa0411533 | Oral cavity | LP | p53 signaling pathway | 38/2418 | 74/8465 | 2.82e-05 | 1.92e-04 | 1.24e-04 | 38 |
hsa041158 | Prostate | BPH | p53 signaling pathway | 30/1718 | 74/8465 | 5.15e-05 | 3.40e-04 | 2.10e-04 | 30 |
hsa0411513 | Prostate | BPH | p53 signaling pathway | 30/1718 | 74/8465 | 5.15e-05 | 3.40e-04 | 2.10e-04 | 30 |
hsa0411522 | Prostate | Tumor | p53 signaling pathway | 29/1791 | 74/8465 | 2.99e-04 | 1.65e-03 | 1.02e-03 | 29 |
hsa0411532 | Prostate | Tumor | p53 signaling pathway | 29/1791 | 74/8465 | 2.99e-04 | 1.65e-03 | 1.02e-03 | 29 |
hsa04115 | Stomach | GC | p53 signaling pathway | 13/708 | 74/8465 | 7.76e-03 | 4.10e-02 | 2.88e-02 | 13 |
hsa041151 | Stomach | GC | p53 signaling pathway | 13/708 | 74/8465 | 7.76e-03 | 4.10e-02 | 2.88e-02 | 13 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIVA1 | SNV | Missense_Mutation | c.221N>A | p.Gly74Asp | p.G74D | O15304 | protein_coding | tolerated(0.08) | benign(0.053) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIVA1 | SNV | Missense_Mutation | rs753479469 | c.395N>A | p.Arg132Gln | p.R132Q | O15304 | protein_coding | tolerated(0.08) | probably_damaging(0.998) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SIVA1 | insertion | Frame_Shift_Ins | novel | c.444_445insA | p.Ala149SerfsTer12 | p.A149Sfs*12 | O15304 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
SIVA1 | SNV | Missense_Mutation | novel | c.92N>T | p.Ala31Val | p.A31V | O15304 | protein_coding | deleterious(0.01) | benign(0.355) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
SIVA1 | SNV | Missense_Mutation | novel | c.255N>T | p.Gln85His | p.Q85H | O15304 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SIVA1 | SNV | Missense_Mutation | rs367890831 | c.329C>T | p.Ala110Val | p.A110V | O15304 | protein_coding | tolerated(0.31) | benign(0.011) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIVA1 | SNV | Missense_Mutation | rs138681592 | c.169G>A | p.Val57Met | p.V57M | O15304 | protein_coding | tolerated(0.4) | benign(0.027) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIVA1 | SNV | Missense_Mutation | novel | c.211C>T | p.Pro71Ser | p.P71S | O15304 | protein_coding | tolerated(0.11) | benign(0.34) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
SIVA1 | SNV | Missense_Mutation | c.397G>A | p.Ala133Thr | p.A133T | O15304 | protein_coding | tolerated(0.39) | possibly_damaging(0.629) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SIVA1 | SNV | Missense_Mutation | rs762902272 | c.247N>T | p.Arg83Cys | p.R83C | O15304 | protein_coding | deleterious(0) | possibly_damaging(0.894) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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