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Gene: SH3RF2 |
Gene summary for SH3RF2 |
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Gene information | Species | Human | Gene symbol | SH3RF2 | Gene ID | 153769 |
Gene name | SH3 domain containing ring finger 2 | |
Gene Alias | HEPP1 | |
Cytomap | 5q32 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q08AM8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
153769 | SH3RF2 | P65T-E | Human | Esophagus | ESCC | 6.09e-06 | 1.74e-01 | 0.0978 |
153769 | SH3RF2 | P74T-E | Human | Esophagus | ESCC | 3.90e-04 | 2.18e-01 | 0.1479 |
153769 | SH3RF2 | P75T-E | Human | Esophagus | ESCC | 4.45e-09 | 9.71e-02 | 0.1125 |
153769 | SH3RF2 | P79T-E | Human | Esophagus | ESCC | 3.75e-02 | 1.35e-02 | 0.1154 |
153769 | SH3RF2 | P80T-E | Human | Esophagus | ESCC | 3.36e-18 | 6.20e-01 | 0.155 |
153769 | SH3RF2 | P82T-E | Human | Esophagus | ESCC | 4.64e-05 | 2.41e-01 | 0.1072 |
153769 | SH3RF2 | P83T-E | Human | Esophagus | ESCC | 4.29e-15 | 5.70e-01 | 0.1738 |
153769 | SH3RF2 | P84T-E | Human | Esophagus | ESCC | 1.56e-02 | 2.56e-01 | 0.0933 |
153769 | SH3RF2 | P91T-E | Human | Esophagus | ESCC | 3.87e-05 | 9.24e-01 | 0.1828 |
153769 | SH3RF2 | P94T-E | Human | Esophagus | ESCC | 9.70e-03 | 3.71e-01 | 0.0879 |
153769 | SH3RF2 | P107T-E | Human | Esophagus | ESCC | 7.55e-14 | 2.72e-01 | 0.171 |
153769 | SH3RF2 | P127T-E | Human | Esophagus | ESCC | 6.01e-05 | 4.44e-02 | 0.0826 |
153769 | SH3RF2 | P130T-E | Human | Esophagus | ESCC | 1.03e-14 | 2.98e-01 | 0.1676 |
153769 | SH3RF2 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.97e-02 | 4.46e-01 | 0.3385 |
153769 | SH3RF2 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.05e-03 | 3.78e-01 | -0.2116 |
153769 | SH3RF2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 2.07e-06 | 2.99e-01 | -0.0166 |
153769 | SH3RF2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 1.04e-09 | 3.39e-01 | -0.0132 |
153769 | SH3RF2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 5.42e-10 | 3.63e-01 | -0.013 |
153769 | SH3RF2 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 4.32e-05 | 2.90e-01 | -0.0121 |
153769 | SH3RF2 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.46e-03 | 5.12e-01 | -0.0961 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217610 | Cervix | CC | regulation of protein catabolic process | 104/2311 | 391/18723 | 9.39e-15 | 9.36e-12 | 104 |
GO:004586210 | Cervix | CC | positive regulation of proteolysis | 95/2311 | 372/18723 | 1.84e-12 | 6.86e-10 | 95 |
GO:190336210 | Cervix | CC | regulation of cellular protein catabolic process | 72/2311 | 255/18723 | 5.98e-12 | 2.10e-09 | 72 |
GO:004573210 | Cervix | CC | positive regulation of protein catabolic process | 65/2311 | 231/18723 | 7.44e-11 | 1.39e-08 | 65 |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:190332010 | Cervix | CC | regulation of protein modification by small protein conjugation or removal | 66/2311 | 242/18723 | 2.31e-10 | 3.46e-08 | 66 |
GO:000989610 | Cervix | CC | positive regulation of catabolic process | 109/2311 | 492/18723 | 5.26e-10 | 6.99e-08 | 109 |
GO:003139610 | Cervix | CC | regulation of protein ubiquitination | 59/2311 | 210/18723 | 5.90e-10 | 7.51e-08 | 59 |
GO:190305010 | Cervix | CC | regulation of proteolysis involved in cellular protein catabolic process | 60/2311 | 221/18723 | 1.82e-09 | 1.98e-07 | 60 |
GO:200005810 | Cervix | CC | regulation of ubiquitin-dependent protein catabolic process | 47/2311 | 164/18723 | 1.63e-08 | 1.25e-06 | 47 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:003133110 | Cervix | CC | positive regulation of cellular catabolic process | 91/2311 | 427/18723 | 9.64e-08 | 5.25e-06 | 91 |
GO:190336410 | Cervix | CC | positive regulation of cellular protein catabolic process | 43/2311 | 155/18723 | 1.80e-07 | 8.28e-06 | 43 |
GO:003139710 | Cervix | CC | negative regulation of protein ubiquitination | 28/2311 | 83/18723 | 3.32e-07 | 1.35e-05 | 28 |
GO:006113610 | Cervix | CC | regulation of proteasomal protein catabolic process | 48/2311 | 187/18723 | 4.63e-07 | 1.77e-05 | 48 |
GO:003243410 | Cervix | CC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 38/2311 | 134/18723 | 4.99e-07 | 1.88e-05 | 38 |
GO:00310988 | Cervix | CC | stress-activated protein kinase signaling cascade | 58/2311 | 247/18723 | 8.02e-07 | 2.89e-05 | 58 |
GO:190332110 | Cervix | CC | negative regulation of protein modification by small protein conjugation or removal | 29/2311 | 95/18723 | 2.15e-06 | 6.55e-05 | 29 |
GO:00514038 | Cervix | CC | stress-activated MAPK cascade | 55/2311 | 239/18723 | 2.96e-06 | 8.31e-05 | 55 |
GO:00703027 | Cervix | CC | regulation of stress-activated protein kinase signaling cascade | 46/2311 | 195/18723 | 9.35e-06 | 2.11e-04 | 46 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SH3RF2 | SNV | Missense_Mutation | c.742G>A | p.Glu248Lys | p.E248K | Q8TEC5 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-B6-A0RL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SH3RF2 | SNV | Missense_Mutation | rs139468138 | c.2075N>A | p.Arg692Gln | p.R692Q | Q8TEC5 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BH-A42T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SH3RF2 | SNV | Missense_Mutation | novel | c.359T>C | p.Val120Ala | p.V120A | Q8TEC5 | protein_coding | tolerated(0.46) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SH3RF2 | SNV | Missense_Mutation | rs747775775 | c.1306N>A | p.Val436Ile | p.V436I | Q8TEC5 | protein_coding | deleterious(0.02) | benign(0.144) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
SH3RF2 | SNV | Missense_Mutation | rs747678660 | c.1585G>A | p.Gly529Arg | p.G529R | Q8TEC5 | protein_coding | tolerated(0.07) | benign(0.031) | TCGA-C5-A7UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
SH3RF2 | SNV | Missense_Mutation | c.1516C>A | p.Gln506Lys | p.Q506K | Q8TEC5 | protein_coding | deleterious(0.01) | benign(0.156) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
SH3RF2 | SNV | Missense_Mutation | rs757233835 | c.496N>A | p.Glu166Lys | p.E166K | Q8TEC5 | protein_coding | deleterious(0.02) | probably_damaging(0.936) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SH3RF2 | SNV | Missense_Mutation | c.2039N>T | p.Ser680Phe | p.S680F | Q8TEC5 | protein_coding | tolerated(0.61) | benign(0.048) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SH3RF2 | SNV | Missense_Mutation | novel | c.935N>C | p.Val312Ala | p.V312A | Q8TEC5 | protein_coding | deleterious(0.05) | probably_damaging(0.918) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SH3RF2 | SNV | Missense_Mutation | rs753470880 | c.1696G>A | p.Val566Met | p.V566M | Q8TEC5 | protein_coding | tolerated(0.25) | benign(0.005) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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