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Gene: SGK3 |
Gene summary for SGK3 |
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Gene information | Species | Human | Gene symbol | SGK3 | Gene ID | 23678 |
Gene name | serum/glucocorticoid regulated kinase family member 3 | |
Gene Alias | CISK | |
Cytomap | 8q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | A0A024R807 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23678 | SGK3 | P31T-E | Human | Esophagus | ESCC | 1.41e-15 | 3.10e-01 | 0.1251 |
23678 | SGK3 | P37T-E | Human | Esophagus | ESCC | 2.46e-05 | 1.16e-01 | 0.1371 |
23678 | SGK3 | P39T-E | Human | Esophagus | ESCC | 3.48e-10 | 1.86e-01 | 0.0894 |
23678 | SGK3 | P40T-E | Human | Esophagus | ESCC | 2.30e-03 | 1.44e-01 | 0.109 |
23678 | SGK3 | P42T-E | Human | Esophagus | ESCC | 6.77e-09 | 2.99e-01 | 0.1175 |
23678 | SGK3 | P47T-E | Human | Esophagus | ESCC | 3.37e-05 | 9.73e-02 | 0.1067 |
23678 | SGK3 | P48T-E | Human | Esophagus | ESCC | 2.89e-05 | 1.45e-01 | 0.0959 |
23678 | SGK3 | P49T-E | Human | Esophagus | ESCC | 1.19e-13 | 1.15e+00 | 0.1768 |
23678 | SGK3 | P52T-E | Human | Esophagus | ESCC | 1.06e-08 | 1.71e-01 | 0.1555 |
23678 | SGK3 | P54T-E | Human | Esophagus | ESCC | 4.32e-09 | 2.71e-01 | 0.0975 |
23678 | SGK3 | P56T-E | Human | Esophagus | ESCC | 1.55e-04 | 8.61e-01 | 0.1613 |
23678 | SGK3 | P57T-E | Human | Esophagus | ESCC | 8.76e-06 | 1.36e-01 | 0.0926 |
23678 | SGK3 | P61T-E | Human | Esophagus | ESCC | 6.97e-04 | 1.61e-01 | 0.099 |
23678 | SGK3 | P62T-E | Human | Esophagus | ESCC | 1.74e-20 | 4.03e-01 | 0.1302 |
23678 | SGK3 | P74T-E | Human | Esophagus | ESCC | 4.87e-09 | 3.03e-01 | 0.1479 |
23678 | SGK3 | P75T-E | Human | Esophagus | ESCC | 3.56e-14 | 2.75e-01 | 0.1125 |
23678 | SGK3 | P76T-E | Human | Esophagus | ESCC | 1.26e-03 | 9.81e-02 | 0.1207 |
23678 | SGK3 | P79T-E | Human | Esophagus | ESCC | 4.79e-13 | 2.26e-01 | 0.1154 |
23678 | SGK3 | P80T-E | Human | Esophagus | ESCC | 4.43e-13 | 4.71e-01 | 0.155 |
23678 | SGK3 | P83T-E | Human | Esophagus | ESCC | 3.20e-07 | 2.60e-01 | 0.1738 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001604913 | Breast | IDC | cell growth | 56/1434 | 482/18723 | 1.16e-03 | 1.26e-02 | 56 |
GO:000155813 | Breast | IDC | regulation of cell growth | 49/1434 | 414/18723 | 1.55e-03 | 1.55e-02 | 49 |
GO:001604923 | Breast | DCIS | cell growth | 54/1390 | 482/18723 | 1.60e-03 | 1.59e-02 | 54 |
GO:000155822 | Breast | DCIS | regulation of cell growth | 47/1390 | 414/18723 | 2.39e-03 | 2.16e-02 | 47 |
GO:00510904 | Cervix | CC | regulation of DNA-binding transcription factor activity | 87/2311 | 440/18723 | 4.85e-06 | 1.22e-04 | 87 |
GO:00160498 | Cervix | CC | cell growth | 92/2311 | 482/18723 | 1.16e-05 | 2.49e-04 | 92 |
GO:00181057 | Cervix | CC | peptidyl-serine phosphorylation | 63/2311 | 315/18723 | 6.65e-05 | 9.47e-04 | 63 |
GO:00182096 | Cervix | CC | peptidyl-serine modification | 66/2311 | 338/18723 | 9.58e-05 | 1.25e-03 | 66 |
GO:00015588 | Cervix | CC | regulation of cell growth | 77/2311 | 414/18723 | 1.40e-04 | 1.70e-03 | 77 |
GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
GO:0001558 | Colorectum | AD | regulation of cell growth | 124/3918 | 414/18723 | 7.67e-06 | 1.86e-04 | 124 |
GO:0018105 | Colorectum | AD | peptidyl-serine phosphorylation | 88/3918 | 315/18723 | 1.73e-03 | 1.43e-02 | 88 |
GO:0018209 | Colorectum | AD | peptidyl-serine modification | 92/3918 | 338/18723 | 3.19e-03 | 2.36e-02 | 92 |
GO:00160492 | Colorectum | MSS | cell growth | 123/3467 | 482/18723 | 7.15e-05 | 1.21e-03 | 123 |
GO:00015582 | Colorectum | MSS | regulation of cell growth | 105/3467 | 414/18723 | 2.97e-04 | 3.90e-03 | 105 |
GO:00181052 | Colorectum | MSS | peptidyl-serine phosphorylation | 81/3467 | 315/18723 | 8.92e-04 | 9.12e-03 | 81 |
GO:0051090 | Colorectum | MSS | regulation of DNA-binding transcription factor activity | 106/3467 | 440/18723 | 1.88e-03 | 1.65e-02 | 106 |
GO:00182091 | Colorectum | MSS | peptidyl-serine modification | 84/3467 | 338/18723 | 2.12e-03 | 1.79e-02 | 84 |
GO:00160493 | Colorectum | FAP | cell growth | 112/2622 | 482/18723 | 2.40e-08 | 2.30e-06 | 112 |
GO:00015583 | Colorectum | FAP | regulation of cell growth | 95/2622 | 414/18723 | 5.02e-07 | 2.61e-05 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04151 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041511 | Colorectum | FAP | PI3K-Akt signaling pathway | 75/1404 | 354/8465 | 1.23e-02 | 4.19e-02 | 2.55e-02 | 75 |
hsa041512 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa041513 | Colorectum | CRC | PI3K-Akt signaling pathway | 64/1091 | 354/8465 | 2.70e-03 | 1.77e-02 | 1.20e-02 | 64 |
hsa040689 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0406814 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SGK3 | SNV | Missense_Mutation | c.425N>G | p.Ser142Cys | p.S142C | Q96BR1 | protein_coding | deleterious(0.03) | benign(0.052) | TCGA-BH-A208-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SGK3 | SNV | Missense_Mutation | c.217N>A | p.Pro73Thr | p.P73T | Q96BR1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A226-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD | |
SGK3 | SNV | Missense_Mutation | c.550N>C | p.Asp184His | p.D184H | Q96BR1 | protein_coding | deleterious(0.01) | possibly_damaging(0.841) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
SGK3 | SNV | Missense_Mutation | c.550G>C | p.Asp184His | p.D184H | Q96BR1 | protein_coding | deleterious(0.01) | possibly_damaging(0.841) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SGK3 | SNV | Missense_Mutation | novel | c.1136G>C | p.Ser379Thr | p.S379T | Q96BR1 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
SGK3 | SNV | Missense_Mutation | novel | c.410N>A | p.Ser137Tyr | p.S137Y | Q96BR1 | protein_coding | tolerated(0.2) | benign(0.013) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SGK3 | SNV | Missense_Mutation | rs146507110 | c.64N>A | p.Asp22Asn | p.D22N | Q96BR1 | protein_coding | tolerated_low_confidence(0.34) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SGK3 | SNV | Missense_Mutation | novel | c.109N>A | p.Leu37Met | p.L37M | Q96BR1 | protein_coding | tolerated(0.2) | benign(0.079) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SGK3 | SNV | Missense_Mutation | rs772372105 | c.286G>A | p.Glu96Lys | p.E96K | Q96BR1 | protein_coding | tolerated(0.17) | possibly_damaging(0.85) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SGK3 | SNV | Missense_Mutation | novel | c.410C>A | p.Ser137Tyr | p.S137Y | Q96BR1 | protein_coding | tolerated(0.2) | benign(0.013) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
23678 | SGK3 | DRUGGABLE GENOME, KINASE, SERINE THREONINE KINASE, ION CHANNEL, TRANSPORTER, ENZYME | inhibitor | 328083523 |
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