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Gene: SERPINA3 |
Gene summary for SERPINA3 |
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Gene information | Species | Human | Gene symbol | SERPINA3 | Gene ID | 12 |
Gene name | serpin family A member 3 | |
Gene Alias | AACT | |
Cytomap | 14q32.13 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | A0A024R6P0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
12 | SERPINA3 | WIM_1 | Human | Stomach | WIM | 1.86e-08 | -5.96e-01 | 0.0335 |
12 | SERPINA3 | WIM_2 | Human | Stomach | WIM | 2.76e-05 | -5.96e-01 | 0.1159 |
12 | SERPINA3 | SIM_1 | Human | Stomach | SIM | 1.22e-15 | -5.96e-01 | 0.3573 |
12 | SERPINA3 | SIM_2 | Human | Stomach | SIM | 5.43e-16 | -5.96e-01 | 0.3139 |
12 | SERPINA3 | SIM_3 | Human | Stomach | SIM | 3.47e-09 | -5.96e-01 | 0.0345 |
12 | SERPINA3 | SIM_4 | Human | Stomach | SIM | 4.75e-13 | -5.96e-01 | 0.2664 |
12 | SERPINA3 | EGC | Human | Stomach | GC | 5.43e-16 | -5.96e-01 | 0.1683 |
12 | SERPINA3 | Pt1_Superficial | Human | Stomach | GC | 1.07e-06 | -5.96e-01 | 0.1036 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:00458619 | Breast | Precancer | negative regulation of proteolysis | 50/1080 | 351/18723 | 2.99e-09 | 2.39e-07 | 50 |
GO:00513468 | Breast | Precancer | negative regulation of hydrolase activity | 50/1080 | 379/18723 | 3.85e-08 | 2.34e-06 | 50 |
GO:00104668 | Breast | Precancer | negative regulation of peptidase activity | 38/1080 | 262/18723 | 1.46e-07 | 7.82e-06 | 38 |
GO:00109519 | Breast | Precancer | negative regulation of endopeptidase activity | 37/1080 | 252/18723 | 1.55e-07 | 8.05e-06 | 37 |
GO:00025263 | Breast | Precancer | acute inflammatory response | 16/1080 | 112/18723 | 6.87e-04 | 8.36e-03 | 16 |
GO:00192164 | Breast | Precancer | regulation of lipid metabolic process | 34/1080 | 331/18723 | 8.14e-04 | 9.55e-03 | 34 |
GO:00018948 | Breast | Precancer | tissue homeostasis | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
GO:005254714 | Breast | IDC | regulation of peptidase activity | 96/1434 | 461/18723 | 7.58e-20 | 6.15e-17 | 96 |
GO:005254814 | Breast | IDC | regulation of endopeptidase activity | 88/1434 | 432/18723 | 1.20e-17 | 4.85e-15 | 88 |
GO:004586114 | Breast | IDC | negative regulation of proteolysis | 70/1434 | 351/18723 | 8.21e-14 | 2.22e-11 | 70 |
GO:005134613 | Breast | IDC | negative regulation of hydrolase activity | 71/1434 | 379/18723 | 1.33e-12 | 2.90e-10 | 71 |
GO:001046613 | Breast | IDC | negative regulation of peptidase activity | 56/1434 | 262/18723 | 1.39e-12 | 2.92e-10 | 56 |
GO:001095112 | Breast | IDC | negative regulation of endopeptidase activity | 52/1434 | 252/18723 | 3.53e-11 | 5.57e-09 | 52 |
GO:001921612 | Breast | IDC | regulation of lipid metabolic process | 45/1434 | 331/18723 | 1.21e-04 | 2.24e-03 | 45 |
GO:000189413 | Breast | IDC | tissue homeostasis | 34/1434 | 268/18723 | 2.54e-03 | 2.28e-02 | 34 |
GO:000252611 | Breast | IDC | acute inflammatory response | 17/1434 | 112/18723 | 5.00e-03 | 3.77e-02 | 17 |
GO:005254723 | Breast | DCIS | regulation of peptidase activity | 88/1390 | 461/18723 | 1.18e-16 | 4.78e-14 | 88 |
GO:005254823 | Breast | DCIS | regulation of endopeptidase activity | 83/1390 | 432/18723 | 6.07e-16 | 2.15e-13 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SERPINA3 | SNV | Missense_Mutation | c.869T>A | p.Met290Lys | p.M290K | P01011 | protein_coding | tolerated(0.47) | benign(0) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
SERPINA3 | SNV | Missense_Mutation | rs536399107 | c.764N>A | p.Arg255Gln | p.R255Q | P01011 | protein_coding | deleterious(0.02) | benign(0.14) | TCGA-PL-A8LX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SERPINA3 | SNV | Missense_Mutation | c.474N>C | p.Lys158Asn | p.K158N | P01011 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
SERPINA3 | SNV | Missense_Mutation | c.474N>C | p.Lys158Asn | p.K158N | P01011 | protein_coding | deleterious(0.01) | possibly_damaging(0.874) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
SERPINA3 | SNV | Missense_Mutation | c.332N>T | p.Ser111Phe | p.S111F | P01011 | protein_coding | deleterious(0) | possibly_damaging(0.881) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SERPINA3 | SNV | Missense_Mutation | c.910G>A | p.Glu304Lys | p.E304K | P01011 | protein_coding | tolerated(0.9) | benign(0) | TCGA-FU-A770-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
SERPINA3 | SNV | Missense_Mutation | novel | c.1242N>C | p.Met414Ile | p.M414I | P01011 | protein_coding | tolerated(0.32) | benign(0.001) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SERPINA3 | SNV | Missense_Mutation | c.868N>C | p.Met290Leu | p.M290L | P01011 | protein_coding | deleterious(0.04) | benign(0.003) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SERPINA3 | SNV | Missense_Mutation | c.869N>A | p.Met290Lys | p.M290K | P01011 | protein_coding | tolerated(0.47) | benign(0) | TCGA-A6-3808-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SERPINA3 | SNV | Missense_Mutation | rs770816070 | c.169N>A | p.Ala57Thr | p.A57T | P01011 | protein_coding | tolerated(0.08) | probably_damaging(0.944) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
12 | SERPINA3 | PROTEASE INHIBITOR, DRUGGABLE GENOME | antineoplastic agents | 21487324 |
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