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Gene: SCAMP3 |
Gene summary for SCAMP3 |
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Gene information | Species | Human | Gene symbol | SCAMP3 | Gene ID | 10067 |
Gene name | secretory carrier membrane protein 3 | |
Gene Alias | C1orf3 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O14828 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10067 | SCAMP3 | S029 | Human | Liver | HCC | 2.67e-35 | 1.84e+00 | 0.2581 |
10067 | SCAMP3 | C04 | Human | Oral cavity | OSCC | 6.47e-31 | 1.17e+00 | 0.2633 |
10067 | SCAMP3 | C21 | Human | Oral cavity | OSCC | 2.00e-68 | 1.57e+00 | 0.2678 |
10067 | SCAMP3 | C30 | Human | Oral cavity | OSCC | 1.07e-43 | 1.73e+00 | 0.3055 |
10067 | SCAMP3 | C38 | Human | Oral cavity | OSCC | 5.30e-19 | 1.32e+00 | 0.172 |
10067 | SCAMP3 | C43 | Human | Oral cavity | OSCC | 6.34e-63 | 1.01e+00 | 0.1704 |
10067 | SCAMP3 | C46 | Human | Oral cavity | OSCC | 2.81e-35 | 7.07e-01 | 0.1673 |
10067 | SCAMP3 | C51 | Human | Oral cavity | OSCC | 1.40e-18 | 8.18e-01 | 0.2674 |
10067 | SCAMP3 | C57 | Human | Oral cavity | OSCC | 1.50e-16 | 5.73e-01 | 0.1679 |
10067 | SCAMP3 | C06 | Human | Oral cavity | OSCC | 1.91e-09 | 1.17e+00 | 0.2699 |
10067 | SCAMP3 | C07 | Human | Oral cavity | OSCC | 4.54e-08 | 1.21e+00 | 0.2491 |
10067 | SCAMP3 | C08 | Human | Oral cavity | OSCC | 1.38e-50 | 8.85e-01 | 0.1919 |
10067 | SCAMP3 | C09 | Human | Oral cavity | OSCC | 2.81e-17 | 4.59e-01 | 0.1431 |
10067 | SCAMP3 | LN22 | Human | Oral cavity | OSCC | 4.12e-08 | 9.02e-01 | 0.1733 |
10067 | SCAMP3 | LN38 | Human | Oral cavity | OSCC | 4.34e-04 | 8.33e-01 | 0.168 |
10067 | SCAMP3 | LN46 | Human | Oral cavity | OSCC | 4.48e-21 | 7.04e-01 | 0.1666 |
10067 | SCAMP3 | LP15 | Human | Oral cavity | LP | 5.29e-18 | 2.75e+00 | 0.2174 |
10067 | SCAMP3 | LP17 | Human | Oral cavity | LP | 6.81e-17 | 1.25e+00 | 0.2349 |
10067 | SCAMP3 | SYSMH1 | Human | Oral cavity | OSCC | 6.12e-11 | 2.65e-01 | 0.1127 |
10067 | SCAMP3 | SYSMH2 | Human | Oral cavity | OSCC | 5.08e-17 | 4.67e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819317 | Esophagus | HGIN | Golgi vesicle transport | 83/2587 | 296/18723 | 8.59e-11 | 8.89e-09 | 83 |
GO:000689210 | Esophagus | HGIN | post-Golgi vesicle-mediated transport | 26/2587 | 104/18723 | 1.63e-03 | 1.81e-02 | 26 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:004819311 | Liver | Cirrhotic | Golgi vesicle transport | 153/4634 | 296/18723 | 1.02e-23 | 6.43e-21 | 153 |
GO:000689211 | Liver | Cirrhotic | post-Golgi vesicle-mediated transport | 51/4634 | 104/18723 | 7.12e-08 | 2.15e-06 | 51 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000689221 | Liver | HCC | post-Golgi vesicle-mediated transport | 77/7958 | 104/18723 | 6.14e-11 | 2.24e-09 | 77 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00068929 | Oral cavity | OSCC | post-Golgi vesicle-mediated transport | 71/7305 | 104/18723 | 1.37e-09 | 3.33e-08 | 71 |
GO:004819316 | Oral cavity | LP | Golgi vesicle transport | 141/4623 | 296/18723 | 6.11e-18 | 1.06e-15 | 141 |
GO:000689214 | Oral cavity | LP | post-Golgi vesicle-mediated transport | 44/4623 | 104/18723 | 5.90e-05 | 8.05e-04 | 44 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:000689217 | Skin | cSCC | post-Golgi vesicle-mediated transport | 49/4864 | 104/18723 | 2.71e-06 | 4.30e-05 | 49 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SCAMP3 | SNV | Missense_Mutation | c.412C>G | p.Leu138Val | p.L138V | O14828 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BH-A0DX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
SCAMP3 | SNV | Missense_Mutation | c.37N>A | p.Glu13Lys | p.E13K | O14828 | protein_coding | deleterious(0.03) | benign(0.015) | TCGA-C8-A12Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
SCAMP3 | SNV | Missense_Mutation | novel | c.280G>C | p.Ala94Pro | p.A94P | O14828 | protein_coding | tolerated(0.09) | possibly_damaging(0.889) | TCGA-C5-A1BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SCAMP3 | SNV | Missense_Mutation | c.115N>C | p.Asp39His | p.D39H | O14828 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EK-A2RC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SCAMP3 | SNV | Missense_Mutation | c.334N>C | p.Glu112Gln | p.E112Q | O14828 | protein_coding | deleterious(0) | benign(0.335) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SCAMP3 | SNV | Missense_Mutation | c.331N>C | p.Glu111Gln | p.E111Q | O14828 | protein_coding | tolerated(0.09) | benign(0.014) | TCGA-LP-A4AV-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SCAMP3 | SNV | Missense_Mutation | novel | c.81N>G | p.Ile27Met | p.I27M | O14828 | protein_coding | tolerated(0.06) | benign(0.233) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SCAMP3 | SNV | Missense_Mutation | novel | c.65N>G | p.Gln22Arg | p.Q22R | O14828 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SCAMP3 | SNV | Missense_Mutation | c.74N>T | p.Ala25Val | p.A25V | O14828 | protein_coding | deleterious(0) | possibly_damaging(0.612) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
SCAMP3 | SNV | Missense_Mutation | novel | c.223N>T | p.Leu75Phe | p.L75F | O14828 | protein_coding | tolerated(0.05) | possibly_damaging(0.454) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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