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Gene: RPS19BP1 |
Gene summary for RPS19BP1 |
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Gene information | Species | Human | Gene symbol | RPS19BP1 | Gene ID | 91582 |
Gene name | ribosomal protein S19 binding protein 1 | |
Gene Alias | AROS | |
Cytomap | 22q13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R1T1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91582 | RPS19BP1 | P39T-E | Human | Esophagus | ESCC | 6.98e-40 | 9.76e-01 | 0.0894 |
91582 | RPS19BP1 | P40T-E | Human | Esophagus | ESCC | 2.24e-33 | 1.17e+00 | 0.109 |
91582 | RPS19BP1 | P42T-E | Human | Esophagus | ESCC | 9.31e-33 | 1.10e+00 | 0.1175 |
91582 | RPS19BP1 | P44T-E | Human | Esophagus | ESCC | 2.65e-29 | 8.45e-01 | 0.1096 |
91582 | RPS19BP1 | P47T-E | Human | Esophagus | ESCC | 1.46e-24 | 5.92e-01 | 0.1067 |
91582 | RPS19BP1 | P48T-E | Human | Esophagus | ESCC | 2.98e-31 | 7.66e-01 | 0.0959 |
91582 | RPS19BP1 | P49T-E | Human | Esophagus | ESCC | 2.53e-20 | 2.59e+00 | 0.1768 |
91582 | RPS19BP1 | P52T-E | Human | Esophagus | ESCC | 4.70e-71 | 1.55e+00 | 0.1555 |
91582 | RPS19BP1 | P54T-E | Human | Esophagus | ESCC | 3.37e-34 | 9.10e-01 | 0.0975 |
91582 | RPS19BP1 | P56T-E | Human | Esophagus | ESCC | 7.07e-12 | 2.06e+00 | 0.1613 |
91582 | RPS19BP1 | P57T-E | Human | Esophagus | ESCC | 5.44e-35 | 8.99e-01 | 0.0926 |
91582 | RPS19BP1 | P61T-E | Human | Esophagus | ESCC | 1.16e-53 | 1.60e+00 | 0.099 |
91582 | RPS19BP1 | P62T-E | Human | Esophagus | ESCC | 9.92e-70 | 1.49e+00 | 0.1302 |
91582 | RPS19BP1 | P65T-E | Human | Esophagus | ESCC | 7.27e-75 | 1.64e+00 | 0.0978 |
91582 | RPS19BP1 | P74T-E | Human | Esophagus | ESCC | 3.15e-62 | 2.06e+00 | 0.1479 |
91582 | RPS19BP1 | P75T-E | Human | Esophagus | ESCC | 3.06e-73 | 1.52e+00 | 0.1125 |
91582 | RPS19BP1 | P76T-E | Human | Esophagus | ESCC | 2.76e-77 | 1.57e+00 | 0.1207 |
91582 | RPS19BP1 | P79T-E | Human | Esophagus | ESCC | 3.29e-56 | 1.14e+00 | 0.1154 |
91582 | RPS19BP1 | P80T-E | Human | Esophagus | ESCC | 1.31e-59 | 1.92e+00 | 0.155 |
91582 | RPS19BP1 | P82T-E | Human | Esophagus | ESCC | 1.89e-28 | 1.76e+00 | 0.1072 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS19BP1 | SNV | Missense_Mutation | novel | c.135N>C | p.Gln45His | p.Q45H | Q86WX3 | protein_coding | tolerated(0.11) | benign(0.281) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RPS19BP1 | SNV | Missense_Mutation | novel | c.306N>T | p.Lys102Asn | p.K102N | Q86WX3 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS19BP1 | SNV | Missense_Mutation | novel | c.245N>T | p.Thr82Met | p.T82M | Q86WX3 | protein_coding | tolerated(0.15) | benign(0.003) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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