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Gene: RPS11 |
Gene summary for RPS11 |
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Gene information | Species | Human | Gene symbol | RPS11 | Gene ID | 6205 |
Gene name | ribosomal protein S11 | |
Gene Alias | S11 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P62280 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6205 | RPS11 | LZE11D | Human | Esophagus | HGIN | 5.86e-07 | -5.35e-01 | -0.005 |
6205 | RPS11 | LZE2T | Human | Esophagus | ESCC | 2.96e-03 | 9.90e-01 | 0.082 |
6205 | RPS11 | LZE3D | Human | Esophagus | HGIN | 2.12e-08 | 1.51e+00 | 0.0668 |
6205 | RPS11 | LZE4T | Human | Esophagus | ESCC | 1.91e-23 | 1.40e+00 | 0.0811 |
6205 | RPS11 | LZE5T | Human | Esophagus | ESCC | 6.42e-19 | 2.11e+00 | 0.0514 |
6205 | RPS11 | LZE7T | Human | Esophagus | ESCC | 2.43e-25 | 2.07e+00 | 0.0667 |
6205 | RPS11 | LZE8T | Human | Esophagus | ESCC | 1.48e-07 | 9.72e-01 | 0.067 |
6205 | RPS11 | LZE20T | Human | Esophagus | ESCC | 3.14e-06 | 7.47e-01 | 0.0662 |
6205 | RPS11 | LZE22D1 | Human | Esophagus | HGIN | 6.35e-07 | 1.06e+00 | 0.0595 |
6205 | RPS11 | LZE22T | Human | Esophagus | ESCC | 3.99e-12 | 1.55e+00 | 0.068 |
6205 | RPS11 | LZE24D1 | Human | Esophagus | HGIN | 7.95e-03 | 1.41e+00 | 0.054 |
6205 | RPS11 | LZE24T | Human | Esophagus | ESCC | 4.49e-26 | 1.61e+00 | 0.0596 |
6205 | RPS11 | LZE21T | Human | Esophagus | ESCC | 5.01e-14 | 1.59e+00 | 0.0655 |
6205 | RPS11 | LZE6T | Human | Esophagus | ESCC | 2.87e-12 | 1.21e+00 | 0.0845 |
6205 | RPS11 | P1T-E | Human | Esophagus | ESCC | 5.76e-31 | 1.95e+00 | 0.0875 |
6205 | RPS11 | P2T-E | Human | Esophagus | ESCC | 5.24e-75 | 2.08e+00 | 0.1177 |
6205 | RPS11 | P4T-E | Human | Esophagus | ESCC | 1.42e-69 | 2.39e+00 | 0.1323 |
6205 | RPS11 | P5T-E | Human | Esophagus | ESCC | 1.61e-62 | 1.51e+00 | 0.1327 |
6205 | RPS11 | P8T-E | Human | Esophagus | ESCC | 1.06e-87 | 3.03e+00 | 0.0889 |
6205 | RPS11 | P9T-E | Human | Esophagus | ESCC | 1.63e-53 | 2.22e+00 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000218110 | Cervix | CC | cytoplasmic translation | 96/2311 | 148/18723 | 4.87e-51 | 2.91e-47 | 96 |
GO:000218115 | Cervix | HSIL_HPV | cytoplasmic translation | 86/737 | 148/18723 | 3.97e-82 | 1.91e-78 | 86 |
GO:000218125 | Cervix | N_HPV | cytoplasmic translation | 42/534 | 148/18723 | 2.61e-30 | 1.19e-26 | 42 |
GO:0002181 | Colorectum | AD | cytoplasmic translation | 109/3918 | 148/18723 | 3.40e-43 | 2.13e-39 | 109 |
GO:00021811 | Colorectum | SER | cytoplasmic translation | 102/2897 | 148/18723 | 1.38e-48 | 8.49e-45 | 102 |
GO:00021812 | Colorectum | MSS | cytoplasmic translation | 108/3467 | 148/18723 | 1.78e-47 | 1.11e-43 | 108 |
GO:00021813 | Colorectum | MSI-H | cytoplasmic translation | 100/1319 | 148/18723 | 1.50e-79 | 8.31e-76 | 100 |
GO:00021814 | Colorectum | FAP | cytoplasmic translation | 76/2622 | 148/18723 | 3.31e-27 | 2.03e-23 | 76 |
GO:00021815 | Colorectum | CRC | cytoplasmic translation | 70/2078 | 148/18723 | 1.53e-28 | 9.16e-25 | 70 |
GO:000218116 | Endometrium | AEH | cytoplasmic translation | 104/2100 | 148/18723 | 1.01e-64 | 6.07e-61 | 104 |
GO:000218117 | Endometrium | EEC | cytoplasmic translation | 104/2168 | 148/18723 | 2.53e-63 | 1.52e-59 | 104 |
GO:000218127 | Esophagus | HGIN | cytoplasmic translation | 108/2587 | 148/18723 | 1.70e-60 | 1.02e-56 | 108 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:014005313 | Esophagus | ESCC | mitochondrial gene expression | 93/8552 | 108/18723 | 1.96e-18 | 2.03e-16 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0517145 | Cervix | N_HPV | Coronavirus disease - COVID-19 | 47/349 | 232/8465 | 1.79e-20 | 4.86e-18 | 3.80e-18 | 47 |
hsa0301045 | Cervix | N_HPV | Ribosome | 39/349 | 167/8465 | 2.05e-19 | 2.79e-17 | 2.18e-17 | 39 |
hsa0517155 | Cervix | N_HPV | Coronavirus disease - COVID-19 | 47/349 | 232/8465 | 1.79e-20 | 4.86e-18 | 3.80e-18 | 47 |
hsa0301055 | Cervix | N_HPV | Ribosome | 39/349 | 167/8465 | 2.05e-19 | 2.79e-17 | 2.18e-17 | 39 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051712 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa051713 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPS11 | SNV | Missense_Mutation | rs11549537 | c.415N>T | p.Arg139Cys | p.R139C | P62280 | protein_coding | tolerated(0.09) | benign(0.029) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPS11 | SNV | Missense_Mutation | c.107N>G | p.Tyr36Cys | p.Y36C | P62280 | protein_coding | deleterious(0) | possibly_damaging(0.765) | TCGA-AZ-4308-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Targeted Molecular therapy | avastin | CR | |
RPS11 | deletion | Frame_Shift_Del | c.158_161delNNNN | p.Gly53AlafsTer24 | p.G53Afs*24 | P62280 | protein_coding | TCGA-AA-A01K-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | CR | |||
RPS11 | SNV | Missense_Mutation | rs746359465 | c.290G>A | p.Arg97His | p.R97H | P62280 | protein_coding | tolerated(0.15) | possibly_damaging(0.903) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
RPS11 | SNV | Missense_Mutation | c.448G>A | p.Gly150Ser | p.G150S | P62280 | protein_coding | tolerated(0.23) | benign(0.056) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPS11 | SNV | Missense_Mutation | novel | c.153N>G | p.Ile51Met | p.I51M | P62280 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
RPS11 | SNV | Missense_Mutation | rs746359465 | c.290N>A | p.Arg97His | p.R97H | P62280 | protein_coding | tolerated(0.15) | possibly_damaging(0.903) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPS11 | SNV | Missense_Mutation | novel | c.409N>G | p.Thr137Ala | p.T137A | P62280 | protein_coding | deleterious(0) | possibly_damaging(0.682) | TCGA-05-4427-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | CR |
RPS11 | SNV | Missense_Mutation | novel | c.208G>A | p.Gly70Arg | p.G70R | P62280 | protein_coding | deleterious(0.02) | probably_damaging(0.992) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR |
RPS11 | SNV | Missense_Mutation | c.95N>C | p.Lys32Thr | p.K32T | P62280 | protein_coding | deleterious(0.02) | benign(0.056) | TCGA-QU-A6IM-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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