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Gene: RNF130 |
Gene summary for RNF130 |
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Gene information | Species | Human | Gene symbol | RNF130 | Gene ID | 55819 |
Gene name | ring finger protein 130 | |
Gene Alias | G1RP | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q86XS8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55819 | RNF130 | P107T-E | Human | Esophagus | ESCC | 4.47e-43 | 1.19e+00 | 0.171 |
55819 | RNF130 | P126T-E | Human | Esophagus | ESCC | 7.76e-03 | 8.03e-01 | 0.1125 |
55819 | RNF130 | P127T-E | Human | Esophagus | ESCC | 9.88e-08 | 5.96e-02 | 0.0826 |
55819 | RNF130 | P128T-E | Human | Esophagus | ESCC | 4.60e-35 | 1.17e+00 | 0.1241 |
55819 | RNF130 | P130T-E | Human | Esophagus | ESCC | 3.13e-78 | 1.53e+00 | 0.1676 |
55819 | RNF130 | NAFLD1 | Human | Liver | NAFLD | 2.79e-02 | 4.68e-01 | -0.04 |
55819 | RNF130 | S43 | Human | Liver | Cirrhotic | 1.64e-12 | 8.29e-03 | -0.0187 |
55819 | RNF130 | HCC1_Meng | Human | Liver | HCC | 1.07e-69 | -1.36e-01 | 0.0246 |
55819 | RNF130 | HCC2_Meng | Human | Liver | HCC | 1.99e-17 | -2.09e-01 | 0.0107 |
55819 | RNF130 | cirrhotic1 | Human | Liver | Cirrhotic | 9.51e-06 | 9.85e-02 | 0.0202 |
55819 | RNF130 | cirrhotic2 | Human | Liver | Cirrhotic | 1.11e-10 | 1.65e-01 | 0.0201 |
55819 | RNF130 | cirrhotic3 | Human | Liver | Cirrhotic | 7.83e-05 | -1.20e-01 | 0.0215 |
55819 | RNF130 | HCC2 | Human | Liver | HCC | 4.87e-03 | 2.73e+00 | 0.5341 |
55819 | RNF130 | HCC5 | Human | Liver | HCC | 1.63e-09 | 1.66e+00 | 0.4932 |
55819 | RNF130 | Pt13.b | Human | Liver | HCC | 3.64e-10 | -8.73e-02 | 0.0251 |
55819 | RNF130 | S014 | Human | Liver | HCC | 1.54e-02 | 4.57e-01 | 0.2254 |
55819 | RNF130 | S027 | Human | Liver | HCC | 1.60e-08 | 9.88e-01 | 0.2446 |
55819 | RNF130 | S028 | Human | Liver | HCC | 8.93e-17 | 1.15e+00 | 0.2503 |
55819 | RNF130 | S029 | Human | Liver | HCC | 7.43e-22 | 1.54e+00 | 0.2581 |
55819 | RNF130 | C04 | Human | Oral cavity | OSCC | 6.01e-08 | 4.84e-01 | 0.2633 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RNF130 | SNV | Missense_Mutation | c.805N>C | p.Glu269Gln | p.E269Q | Q86XS8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RNF130 | insertion | In_Frame_Ins | novel | c.285_286insAGAGGTGGGCTAGCAGAGGAGAGCCAG | p.Phe95_Phe96insArgGlyGlyLeuAlaGluGluSerGln | p.F95_F96insRGGLAEESQ | Q86XS8 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
RNF130 | SNV | Missense_Mutation | c.449N>C | p.Gly150Ala | p.G150A | Q86XS8 | protein_coding | deleterious(0.03) | possibly_damaging(0.574) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
RNF130 | SNV | Missense_Mutation | c.285C>A | p.Phe95Leu | p.F95L | Q86XS8 | protein_coding | deleterious(0.01) | benign(0.276) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RNF130 | SNV | Missense_Mutation | c.682N>A | p.Asp228Asn | p.D228N | Q86XS8 | protein_coding | tolerated(0.4) | benign(0.246) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RNF130 | SNV | Missense_Mutation | c.694C>T | p.Arg232Cys | p.R232C | Q86XS8 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RNF130 | SNV | Missense_Mutation | c.1246N>T | p.Val416Leu | p.V416L | Q86XS8 | protein_coding | tolerated_low_confidence(0.41) | benign(0) | TCGA-AG-A015-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
RNF130 | SNV | Missense_Mutation | c.818N>T | p.Gln273Leu | p.Q273L | Q86XS8 | protein_coding | tolerated(0.33) | benign(0) | TCGA-F5-6571-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | capecitabine | SD | |
RNF130 | deletion | Frame_Shift_Del | c.305_308delNNNN | p.Lys102SerfsTer28 | p.K102Sfs*28 | Q86XS8 | protein_coding | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
RNF130 | SNV | Missense_Mutation | rs370848810 | c.697N>T | p.Arg233Cys | p.R233C | Q86XS8 | protein_coding | deleterious(0) | benign(0.143) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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