Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/RMDN3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/RMDN3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/RMDN3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/RMDN3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RMDN3 | SNV | Missense_Mutation | | c.487N>G | p.Ser163Ala | p.S163A | Q96TC7 | protein_coding | tolerated(0.16) | benign(0.203) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
RMDN3 | SNV | Missense_Mutation | | c.556N>A | p.Glu186Lys | p.E186K | Q96TC7 | protein_coding | deleterious(0.01) | benign(0.298) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
RMDN3 | SNV | Missense_Mutation | novel | c.568G>A | p.Asp190Asn | p.D190N | Q96TC7 | protein_coding | deleterious(0.01) | benign(0.426) | TCGA-E2-A2P6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
RMDN3 | insertion | Nonsense_Mutation | novel | c.571_572insGCTTCCTGTGGGAAGGTGACTGACTG | p.Lys191SerfsTer8 | p.K191Sfs*8 | Q96TC7 | protein_coding | | | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
RMDN3 | insertion | Frame_Shift_Ins | novel | c.1179_1180insTG | p.Pro394CysfsTer15 | p.P394Cfs*15 | Q96TC7 | protein_coding | | | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
RMDN3 | insertion | Nonsense_Mutation | novel | c.1178_1179insGAGGTAAGGCTTTTTAATA | p.Ser393ArgfsTer3 | p.S393Rfs*3 | Q96TC7 | protein_coding | | | TCGA-A8-A097-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
RMDN3 | insertion | Frame_Shift_Ins | novel | c.1158_1159insTTTCCCAGGCTGAAGAACTACAGCCAGGATTTTCCAAAGCAGGAAGG | p.Ala387PhefsTer37 | p.A387Ffs*37 | Q96TC7 | protein_coding | | | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
RMDN3 | deletion | Frame_Shift_Del | | c.735delN | p.Asp246ThrfsTer49 | p.D246Tfs*49 | Q96TC7 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
RMDN3 | SNV | Missense_Mutation | novel | c.671N>G | p.Ser224Cys | p.S224C | Q96TC7 | protein_coding | deleterious(0.05) | benign(0.151) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RMDN3 | SNV | Missense_Mutation | novel | c.514N>G | p.Ser172Gly | p.S172G | Q96TC7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |