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Gene: RCOR3 |
Gene summary for RCOR3 |
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Gene information | Species | Human | Gene symbol | RCOR3 | Gene ID | 55758 |
Gene name | REST corepressor 3 | |
Gene Alias | RCOR3 | |
Cytomap | 1q32.2-q32.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9P2K3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55758 | RCOR3 | Dong_P4 | Human | Prostate | Tumor | 8.15e-06 | 1.76e-01 | 0.0292 |
55758 | RCOR3 | Dong_P5 | Human | Prostate | Tumor | 7.42e-14 | 6.58e-02 | 0.053 |
55758 | RCOR3 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 1.91e-11 | 6.40e-01 | 0.1633 |
55758 | RCOR3 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 3.05e-04 | 4.37e-01 | 0.1608 |
55758 | RCOR3 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 9.01e-06 | 4.99e-01 | 0.1604 |
55758 | RCOR3 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 5.93e-04 | 4.49e-01 | 0.1621 |
55758 | RCOR3 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.43e-04 | 5.74e-01 | 0.1608 |
55758 | RCOR3 | male-WTA | Human | Thyroid | PTC | 1.06e-29 | 1.57e-01 | 0.1037 |
55758 | RCOR3 | PTC01 | Human | Thyroid | PTC | 1.52e-12 | 8.72e-02 | 0.1899 |
55758 | RCOR3 | PTC03 | Human | Thyroid | PTC | 1.05e-03 | 1.63e-01 | 0.1784 |
55758 | RCOR3 | PTC04 | Human | Thyroid | PTC | 2.60e-28 | 3.99e-01 | 0.1927 |
55758 | RCOR3 | PTC05 | Human | Thyroid | PTC | 1.91e-16 | 8.62e-01 | 0.2065 |
55758 | RCOR3 | PTC06 | Human | Thyroid | PTC | 2.82e-34 | 6.24e-01 | 0.2057 |
55758 | RCOR3 | PTC07 | Human | Thyroid | PTC | 3.28e-36 | 5.12e-01 | 0.2044 |
55758 | RCOR3 | ATC09 | Human | Thyroid | ATC | 1.14e-03 | -1.22e-02 | 0.2871 |
55758 | RCOR3 | ATC12 | Human | Thyroid | ATC | 2.97e-16 | -1.50e-02 | 0.34 |
55758 | RCOR3 | ATC13 | Human | Thyroid | ATC | 3.60e-31 | 2.11e-01 | 0.34 |
55758 | RCOR3 | ATC1 | Human | Thyroid | ATC | 2.51e-02 | 1.89e-02 | 0.2878 |
55758 | RCOR3 | ATC2 | Human | Thyroid | ATC | 3.76e-05 | 4.89e-01 | 0.34 |
55758 | RCOR3 | ATC3 | Human | Thyroid | ATC | 2.51e-03 | 1.73e-01 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:00165703 | Liver | NAFLD | histone modification | 90/1882 | 463/18723 | 5.74e-10 | 1.28e-07 | 90 |
GO:0006476 | Liver | NAFLD | protein deacetylation | 19/1882 | 101/18723 | 5.29e-03 | 4.09e-02 | 19 |
GO:001657021 | Liver | HCC | histone modification | 283/7958 | 463/18723 | 2.68e-16 | 2.33e-14 | 283 |
GO:0098732 | Liver | HCC | macromolecule deacylation | 67/7958 | 116/18723 | 6.46e-04 | 3.99e-03 | 67 |
GO:00356011 | Liver | HCC | protein deacylation | 64/7958 | 112/18723 | 1.23e-03 | 6.83e-03 | 64 |
GO:00064761 | Liver | HCC | protein deacetylation | 55/7958 | 101/18723 | 1.01e-02 | 3.79e-02 | 55 |
GO:00165704 | Lung | IAC | histone modification | 93/2061 | 463/18723 | 5.41e-09 | 8.03e-07 | 93 |
GO:00064762 | Lung | IAC | protein deacetylation | 25/2061 | 101/18723 | 7.38e-05 | 1.55e-03 | 25 |
GO:0016575 | Lung | IAC | histone deacetylation | 21/2061 | 82/18723 | 1.62e-04 | 2.92e-03 | 21 |
GO:00356012 | Lung | IAC | protein deacylation | 25/2061 | 112/18723 | 4.18e-04 | 6.25e-03 | 25 |
GO:00987322 | Lung | IAC | macromolecule deacylation | 25/2061 | 116/18723 | 7.26e-04 | 9.60e-03 | 25 |
GO:001657012 | Lung | AIS | histone modification | 81/1849 | 463/18723 | 2.30e-07 | 2.16e-05 | 81 |
GO:000647611 | Lung | AIS | protein deacetylation | 23/1849 | 101/18723 | 1.06e-04 | 2.54e-03 | 23 |
GO:00165751 | Lung | AIS | histone deacetylation | 19/1849 | 82/18723 | 3.23e-04 | 5.84e-03 | 19 |
GO:003560111 | Lung | AIS | protein deacylation | 23/1849 | 112/18723 | 5.25e-04 | 8.42e-03 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RCOR3 | SNV | Missense_Mutation | novel | c.1139G>T | p.Gly380Val | p.G380V | Q9P2K3 | protein_coding | tolerated(0.63) | possibly_damaging(0.881) | TCGA-A7-A56D-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
RCOR3 | SNV | Missense_Mutation | rs773567709 | c.1340N>A | p.Arg447Gln | p.R447Q | Q9P2K3 | protein_coding | tolerated(0.6) | benign(0) | TCGA-B6-A0RM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RCOR3 | SNV | Missense_Mutation | c.1466N>T | p.Gln489Leu | p.Q489L | Q9P2K3 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RCOR3 | SNV | Missense_Mutation | c.1263N>C | p.Glu421Asp | p.E421D | Q9P2K3 | protein_coding | tolerated(0.39) | benign(0) | TCGA-D8-A13Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
RCOR3 | SNV | Missense_Mutation | rs763801630 | c.1409N>C | p.Asn470Thr | p.N470T | Q9P2K3 | protein_coding | tolerated(0.38) | benign(0.402) | TCGA-E9-A227-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
RCOR3 | SNV | Missense_Mutation | novel | c.173N>T | p.Gly58Val | p.G58V | Q9P2K3 | protein_coding | tolerated(0.15) | probably_damaging(0.999) | TCGA-EA-A556-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RCOR3 | SNV | Missense_Mutation | novel | c.1312N>C | p.Glu438Gln | p.E438Q | Q9P2K3 | protein_coding | tolerated(0.16) | benign(0.192) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RCOR3 | SNV | Missense_Mutation | rs768561869 | c.1451C>T | p.Pro484Leu | p.P484L | Q9P2K3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RCOR3 | SNV | Missense_Mutation | c.1273G>A | p.Ala425Thr | p.A425T | Q9P2K3 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
RCOR3 | SNV | Missense_Mutation | rs773567709 | c.1340N>A | p.Arg447Gln | p.R447Q | Q9P2K3 | protein_coding | tolerated(0.6) | benign(0) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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