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Gene: PVT1 |
Gene summary for PVT1 |
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Gene information | Species | Human | Gene symbol | PVT1 | Gene ID | 5820 |
Gene name | Pvt1 oncogene | |
Gene Alias | LINC00079 | |
Cytomap | 8q24.21 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5820 | PVT1 | P16T-E | Human | Esophagus | ESCC | 1.24e-41 | 8.16e-01 | 0.1153 |
5820 | PVT1 | P17T-E | Human | Esophagus | ESCC | 3.14e-04 | 2.88e-01 | 0.1278 |
5820 | PVT1 | P19T-E | Human | Esophagus | ESCC | 5.85e-03 | 3.04e-01 | 0.1662 |
5820 | PVT1 | P20T-E | Human | Esophagus | ESCC | 7.04e-41 | 8.54e-01 | 0.1124 |
5820 | PVT1 | P21T-E | Human | Esophagus | ESCC | 8.54e-27 | 5.47e-01 | 0.1617 |
5820 | PVT1 | P22T-E | Human | Esophagus | ESCC | 4.20e-39 | 6.94e-01 | 0.1236 |
5820 | PVT1 | P23T-E | Human | Esophagus | ESCC | 1.98e-14 | 4.03e-01 | 0.108 |
5820 | PVT1 | P24T-E | Human | Esophagus | ESCC | 7.55e-17 | 3.51e-01 | 0.1287 |
5820 | PVT1 | P26T-E | Human | Esophagus | ESCC | 3.06e-124 | 3.43e+00 | 0.1276 |
5820 | PVT1 | P27T-E | Human | Esophagus | ESCC | 1.15e-27 | 5.58e-01 | 0.1055 |
5820 | PVT1 | P28T-E | Human | Esophagus | ESCC | 5.00e-50 | 8.51e-01 | 0.1149 |
5820 | PVT1 | P30T-E | Human | Esophagus | ESCC | 5.88e-41 | 1.25e+00 | 0.137 |
5820 | PVT1 | P31T-E | Human | Esophagus | ESCC | 2.01e-26 | 5.50e-01 | 0.1251 |
5820 | PVT1 | P32T-E | Human | Esophagus | ESCC | 4.70e-19 | 4.20e-01 | 0.1666 |
5820 | PVT1 | P36T-E | Human | Esophagus | ESCC | 2.82e-26 | 7.87e-01 | 0.1187 |
5820 | PVT1 | P37T-E | Human | Esophagus | ESCC | 3.47e-60 | 1.51e+00 | 0.1371 |
5820 | PVT1 | P38T-E | Human | Esophagus | ESCC | 1.35e-06 | 3.95e-01 | 0.127 |
5820 | PVT1 | P39T-E | Human | Esophagus | ESCC | 1.74e-17 | 3.47e-01 | 0.0894 |
5820 | PVT1 | P40T-E | Human | Esophagus | ESCC | 9.48e-12 | 4.00e-01 | 0.109 |
5820 | PVT1 | P42T-E | Human | Esophagus | ESCC | 1.08e-30 | 6.96e-01 | 0.1175 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5820 | PVT1 | NA | GLIVEC | GLIVEC | 15251464 |
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