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Gene: PTTG1IP |
Gene summary for PTTG1IP |
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Gene information | Species | Human | Gene symbol | PTTG1IP | Gene ID | 754 |
Gene name | PTTG1 interacting protein | |
Gene Alias | C21orf1 | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B4DPZ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
754 | PTTG1IP | P44T-E | Human | Esophagus | ESCC | 5.82e-22 | 1.01e+00 | 0.1096 |
754 | PTTG1IP | P47T-E | Human | Esophagus | ESCC | 1.18e-23 | 7.25e-01 | 0.1067 |
754 | PTTG1IP | P48T-E | Human | Esophagus | ESCC | 1.27e-18 | 3.55e-01 | 0.0959 |
754 | PTTG1IP | P49T-E | Human | Esophagus | ESCC | 8.59e-17 | 1.72e+00 | 0.1768 |
754 | PTTG1IP | P52T-E | Human | Esophagus | ESCC | 5.14e-25 | 7.81e-01 | 0.1555 |
754 | PTTG1IP | P54T-E | Human | Esophagus | ESCC | 1.28e-26 | 8.73e-01 | 0.0975 |
754 | PTTG1IP | P56T-E | Human | Esophagus | ESCC | 1.43e-13 | 1.81e+00 | 0.1613 |
754 | PTTG1IP | P57T-E | Human | Esophagus | ESCC | 7.88e-37 | 9.47e-01 | 0.0926 |
754 | PTTG1IP | P61T-E | Human | Esophagus | ESCC | 6.82e-07 | 2.68e-01 | 0.099 |
754 | PTTG1IP | P62T-E | Human | Esophagus | ESCC | 5.67e-83 | 1.76e+00 | 0.1302 |
754 | PTTG1IP | P65T-E | Human | Esophagus | ESCC | 3.32e-35 | 8.52e-01 | 0.0978 |
754 | PTTG1IP | P74T-E | Human | Esophagus | ESCC | 7.46e-57 | 1.84e+00 | 0.1479 |
754 | PTTG1IP | P75T-E | Human | Esophagus | ESCC | 4.99e-52 | 1.42e+00 | 0.1125 |
754 | PTTG1IP | P76T-E | Human | Esophagus | ESCC | 6.44e-48 | 1.17e+00 | 0.1207 |
754 | PTTG1IP | P79T-E | Human | Esophagus | ESCC | 6.77e-45 | 1.13e+00 | 0.1154 |
754 | PTTG1IP | P80T-E | Human | Esophagus | ESCC | 5.07e-32 | 1.01e+00 | 0.155 |
754 | PTTG1IP | P82T-E | Human | Esophagus | ESCC | 1.15e-33 | 2.65e+00 | 0.1072 |
754 | PTTG1IP | P83T-E | Human | Esophagus | ESCC | 1.29e-47 | 1.51e+00 | 0.1738 |
754 | PTTG1IP | P84T-E | Human | Esophagus | ESCC | 4.92e-22 | 1.97e+00 | 0.0933 |
754 | PTTG1IP | P89T-E | Human | Esophagus | ESCC | 1.61e-19 | 1.40e+00 | 0.1752 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042176 | Colorectum | AD | regulation of protein catabolic process | 160/3918 | 391/18723 | 1.06e-19 | 7.34e-17 | 160 |
GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
GO:1903362 | Colorectum | AD | regulation of cellular protein catabolic process | 109/3918 | 255/18723 | 2.14e-15 | 6.08e-13 | 109 |
GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0045732 | Colorectum | AD | positive regulation of protein catabolic process | 92/3918 | 231/18723 | 3.85e-11 | 4.47e-09 | 92 |
GO:0097193 | Colorectum | AD | intrinsic apoptotic signaling pathway | 108/3918 | 288/18723 | 6.25e-11 | 6.41e-09 | 108 |
GO:2001242 | Colorectum | AD | regulation of intrinsic apoptotic signaling pathway | 67/3918 | 164/18723 | 4.94e-09 | 3.16e-07 | 67 |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:1903364 | Colorectum | AD | positive regulation of cellular protein catabolic process | 62/3918 | 155/18723 | 4.66e-08 | 2.51e-06 | 62 |
GO:1903320 | Colorectum | AD | regulation of protein modification by small protein conjugation or removal | 86/3918 | 242/18723 | 9.43e-08 | 4.65e-06 | 86 |
GO:0006913 | Colorectum | AD | nucleocytoplasmic transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0051169 | Colorectum | AD | nuclear transport | 102/3918 | 301/18723 | 1.00e-07 | 4.85e-06 | 102 |
GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
GO:0031396 | Colorectum | AD | regulation of protein ubiquitination | 72/3918 | 210/18723 | 4.50e-06 | 1.21e-04 | 72 |
GO:0072331 | Colorectum | AD | signal transduction by p53 class mediator | 58/3918 | 163/18723 | 1.04e-05 | 2.40e-04 | 58 |
GO:2001234 | Colorectum | AD | negative regulation of apoptotic signaling pathway | 74/3918 | 224/18723 | 1.49e-05 | 3.18e-04 | 74 |
GO:2001243 | Colorectum | AD | negative regulation of intrinsic apoptotic signaling pathway | 39/3918 | 98/18723 | 1.58e-05 | 3.34e-04 | 39 |
GO:2001020 | Colorectum | AD | regulation of response to DNA damage stimulus | 71/3918 | 219/18723 | 4.38e-05 | 7.65e-04 | 71 |
GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTTG1IP | SNV | Missense_Mutation | novel | c.457N>A | p.Glu153Lys | p.E153K | P53801 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | c.124N>G | p.Gln42Glu | p.Q42E | P53801 | protein_coding | tolerated(1) | benign(0.003) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PTTG1IP | SNV | Missense_Mutation | rs138357182 | c.308N>T | p.Ser103Leu | p.S103L | P53801 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | rs758698293 | c.151N>C | p.Cys51Arg | p.C51R | P53801 | protein_coding | deleterious(0) | benign(0.332) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
PTTG1IP | SNV | Missense_Mutation | rs374480622 | c.418N>T | p.Arg140Trp | p.R140W | P53801 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | c.259N>T | p.Arg87Cys | p.R87C | P53801 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTTG1IP | SNV | Missense_Mutation | rs778141805 | c.449G>A | p.Arg150Gln | p.R150Q | P53801 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | novel | c.466A>T | p.Thr156Ser | p.T156S | P53801 | protein_coding | tolerated(0.43) | benign(0.005) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | novel | c.130A>G | p.Thr44Ala | p.T44A | P53801 | protein_coding | deleterious(0.01) | benign(0.005) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTTG1IP | SNV | Missense_Mutation | c.177N>C | p.Trp59Cys | p.W59C | P53801 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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