![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PTRHD1 |
Gene summary for PTRHD1 |
![]() |
Gene information | Species | Human | Gene symbol | PTRHD1 | Gene ID | 391356 |
Gene name | peptidyl-tRNA hydrolase domain containing 1 | |
Gene Alias | C2orf79 | |
Cytomap | 2p23.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q6GMV3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
391356 | PTRHD1 | P61T-E | Human | Esophagus | ESCC | 4.29e-15 | 4.81e-01 | 0.099 |
391356 | PTRHD1 | P62T-E | Human | Esophagus | ESCC | 1.79e-66 | 1.39e+00 | 0.1302 |
391356 | PTRHD1 | P65T-E | Human | Esophagus | ESCC | 5.41e-21 | 4.83e-01 | 0.0978 |
391356 | PTRHD1 | P74T-E | Human | Esophagus | ESCC | 5.85e-42 | 1.35e+00 | 0.1479 |
391356 | PTRHD1 | P75T-E | Human | Esophagus | ESCC | 2.73e-32 | 9.08e-01 | 0.1125 |
391356 | PTRHD1 | P76T-E | Human | Esophagus | ESCC | 1.15e-44 | 9.70e-01 | 0.1207 |
391356 | PTRHD1 | P79T-E | Human | Esophagus | ESCC | 4.35e-37 | 9.36e-01 | 0.1154 |
391356 | PTRHD1 | P80T-E | Human | Esophagus | ESCC | 3.91e-56 | 1.75e+00 | 0.155 |
391356 | PTRHD1 | P82T-E | Human | Esophagus | ESCC | 1.00e-28 | 1.41e+00 | 0.1072 |
391356 | PTRHD1 | P83T-E | Human | Esophagus | ESCC | 2.71e-55 | 1.76e+00 | 0.1738 |
391356 | PTRHD1 | P84T-E | Human | Esophagus | ESCC | 2.53e-03 | 3.34e-01 | 0.0933 |
391356 | PTRHD1 | P89T-E | Human | Esophagus | ESCC | 1.02e-23 | 1.97e+00 | 0.1752 |
391356 | PTRHD1 | P91T-E | Human | Esophagus | ESCC | 5.14e-09 | 1.38e+00 | 0.1828 |
391356 | PTRHD1 | P107T-E | Human | Esophagus | ESCC | 3.34e-70 | 1.75e+00 | 0.171 |
391356 | PTRHD1 | P126T-E | Human | Esophagus | ESCC | 4.64e-06 | 8.75e-01 | 0.1125 |
391356 | PTRHD1 | P127T-E | Human | Esophagus | ESCC | 7.69e-20 | 3.95e-01 | 0.0826 |
391356 | PTRHD1 | P128T-E | Human | Esophagus | ESCC | 2.73e-47 | 1.63e+00 | 0.1241 |
391356 | PTRHD1 | P130T-E | Human | Esophagus | ESCC | 1.13e-77 | 2.08e+00 | 0.1676 |
391356 | PTRHD1 | HCC1_Meng | Human | Liver | HCC | 1.39e-83 | 3.84e-01 | 0.0246 |
391356 | PTRHD1 | HCC2_Meng | Human | Liver | HCC | 5.40e-31 | 9.61e-02 | 0.0107 |
Page: 1 2 3 4 5 6 7 8 9 10 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTRHD1 | SNV | Missense_Mutation | c.109N>A | p.Gln37Lys | p.Q37K | Q6GMV3 | protein_coding | tolerated(1) | benign(0.007) | TCGA-AR-A1AR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Docetaxel | PD | |
PTRHD1 | SNV | Missense_Mutation | novel | c.99G>T | p.Lys33Asn | p.K33N | Q6GMV3 | protein_coding | tolerated(0.2) | benign(0.346) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PTRHD1 | SNV | Missense_Mutation | c.122C>T | p.Ser41Phe | p.S41F | Q6GMV3 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
PTRHD1 | SNV | Missense_Mutation | c.278N>C | p.Glu93Ala | p.E93A | Q6GMV3 | protein_coding | tolerated(0.64) | benign(0.001) | TCGA-CI-6624-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTRHD1 | SNV | Missense_Mutation | c.347N>T | p.Ala116Val | p.A116V | Q6GMV3 | protein_coding | deleterious(0) | benign(0.112) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
PTRHD1 | SNV | Missense_Mutation | c.314A>C | p.His105Pro | p.H105P | Q6GMV3 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
PTRHD1 | SNV | Missense_Mutation | novel | c.226N>T | p.Gly76Trp | p.G76W | Q6GMV3 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-49-6761-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PTRHD1 | SNV | Missense_Mutation | c.29N>C | p.Arg10Pro | p.R10P | Q6GMV3 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-49-AAR3-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PTRHD1 | SNV | Missense_Mutation | c.313N>G | p.His105Asp | p.H105D | Q6GMV3 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-91-6848-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
PTRHD1 | SNV | Missense_Mutation | novel | c.381N>C | p.Glu127Asp | p.E127D | Q6GMV3 | protein_coding | tolerated(0.56) | possibly_damaging(0.751) | TCGA-KK-A8IG-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |