![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PTAR1 |
Gene summary for PTAR1 |
![]() |
Gene information | Species | Human | Gene symbol | PTAR1 | Gene ID | 375743 |
Gene name | protein prenyltransferase alpha subunit repeat containing 1 | |
Gene Alias | PTAR1 | |
Cytomap | 9q21.12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q7Z6K3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375743 | PTAR1 | P61T-E | Human | Esophagus | ESCC | 3.01e-04 | 1.26e-01 | 0.099 |
375743 | PTAR1 | P62T-E | Human | Esophagus | ESCC | 2.51e-22 | 4.39e-01 | 0.1302 |
375743 | PTAR1 | P65T-E | Human | Esophagus | ESCC | 8.26e-04 | 5.69e-02 | 0.0978 |
375743 | PTAR1 | P74T-E | Human | Esophagus | ESCC | 4.61e-11 | 2.22e-01 | 0.1479 |
375743 | PTAR1 | P75T-E | Human | Esophagus | ESCC | 4.41e-13 | 3.29e-01 | 0.1125 |
375743 | PTAR1 | P76T-E | Human | Esophagus | ESCC | 2.03e-11 | 2.95e-01 | 0.1207 |
375743 | PTAR1 | P79T-E | Human | Esophagus | ESCC | 1.76e-15 | 1.85e-01 | 0.1154 |
375743 | PTAR1 | P80T-E | Human | Esophagus | ESCC | 1.38e-08 | 2.78e-01 | 0.155 |
375743 | PTAR1 | P82T-E | Human | Esophagus | ESCC | 8.37e-09 | 3.06e-01 | 0.1072 |
375743 | PTAR1 | P83T-E | Human | Esophagus | ESCC | 6.37e-09 | 3.12e-01 | 0.1738 |
375743 | PTAR1 | P89T-E | Human | Esophagus | ESCC | 1.97e-03 | 2.82e-01 | 0.1752 |
375743 | PTAR1 | P91T-E | Human | Esophagus | ESCC | 6.04e-03 | 4.87e-01 | 0.1828 |
375743 | PTAR1 | P107T-E | Human | Esophagus | ESCC | 2.43e-16 | 4.25e-01 | 0.171 |
375743 | PTAR1 | P127T-E | Human | Esophagus | ESCC | 3.40e-05 | 1.35e-01 | 0.0826 |
375743 | PTAR1 | P128T-E | Human | Esophagus | ESCC | 2.38e-14 | 3.29e-01 | 0.1241 |
375743 | PTAR1 | P130T-E | Human | Esophagus | ESCC | 6.40e-13 | 2.65e-01 | 0.1676 |
375743 | PTAR1 | P5_S10_cSCC | Human | Skin | cSCC | 3.98e-03 | 8.42e-02 | -0.299 |
375743 | PTAR1 | P1_cSCC | Human | Skin | cSCC | 8.88e-09 | 2.93e-01 | 0.0292 |
375743 | PTAR1 | P2_cSCC | Human | Skin | cSCC | 2.96e-04 | 1.52e-01 | -0.024 |
375743 | PTAR1 | P4_cSCC | Human | Skin | cSCC | 5.76e-08 | 1.52e-01 | -0.00290000000000005 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTAR1 | SNV | Missense_Mutation | c.905N>G | p.Leu302Arg | p.L302R | Q7Z6K3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A0JI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
PTAR1 | SNV | Missense_Mutation | novel | c.761N>G | p.Asp254Gly | p.D254G | Q7Z6K3 | protein_coding | deleterious(0.01) | benign(0.175) | TCGA-AR-A24N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTAR1 | SNV | Missense_Mutation | novel | c.91G>A | p.Glu31Lys | p.E31K | Q7Z6K3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PTAR1 | SNV | Missense_Mutation | c.197C>G | p.Pro66Arg | p.P66R | Q7Z6K3 | protein_coding | tolerated(0.06) | probably_damaging(0.96) | TCGA-C5-A1M9-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
PTAR1 | SNV | Missense_Mutation | c.682N>G | p.Ser228Ala | p.S228A | Q7Z6K3 | protein_coding | deleterious(0.04) | benign(0.254) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
PTAR1 | SNV | Missense_Mutation | c.630G>C | p.Lys210Asn | p.K210N | Q7Z6K3 | protein_coding | tolerated(0.18) | benign(0.01) | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PTAR1 | SNV | Missense_Mutation | c.352A>C | p.Asn118His | p.N118H | Q7Z6K3 | protein_coding | tolerated(0.07) | benign(0.429) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PTAR1 | SNV | Missense_Mutation | rs201402192 | c.949N>T | p.Arg317Trp | p.R317W | Q7Z6K3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PTAR1 | SNV | Missense_Mutation | rs755835716 | c.26N>T | p.Ala9Val | p.A9V | Q7Z6K3 | protein_coding | deleterious_low_confidence(0.03) | benign(0.072) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PTAR1 | SNV | Missense_Mutation | c.1205A>G | p.Gln402Arg | p.Q402R | Q7Z6K3 | protein_coding | deleterious_low_confidence(0.01) | benign(0.057) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |