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Gene: PRKRIP1 |
Gene summary for PRKRIP1 |
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Gene information | Species | Human | Gene symbol | PRKRIP1 | Gene ID | 79706 |
Gene name | PRKR interacting protein 1 | |
Gene Alias | C114 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | A0A024QYV5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79706 | PRKRIP1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.93e-04 | 4.06e-01 | -0.2119 |
79706 | PRKRIP1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 9.79e-10 | 4.11e-01 | -0.0166 |
79706 | PRKRIP1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 9.57e-14 | 4.57e-01 | -0.0132 |
79706 | PRKRIP1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.26e-12 | 4.22e-01 | -0.013 |
79706 | PRKRIP1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 6.88e-09 | 4.26e-01 | -0.0121 |
79706 | PRKRIP1 | C04 | Human | Oral cavity | OSCC | 2.36e-12 | 7.15e-01 | 0.2633 |
79706 | PRKRIP1 | C21 | Human | Oral cavity | OSCC | 1.70e-32 | 1.00e+00 | 0.2678 |
79706 | PRKRIP1 | C30 | Human | Oral cavity | OSCC | 1.37e-22 | 1.15e+00 | 0.3055 |
79706 | PRKRIP1 | C43 | Human | Oral cavity | OSCC | 2.21e-15 | 3.40e-01 | 0.1704 |
79706 | PRKRIP1 | C46 | Human | Oral cavity | OSCC | 7.93e-10 | 3.02e-01 | 0.1673 |
79706 | PRKRIP1 | C51 | Human | Oral cavity | OSCC | 1.12e-04 | 4.34e-01 | 0.2674 |
79706 | PRKRIP1 | C57 | Human | Oral cavity | OSCC | 5.13e-06 | 2.87e-01 | 0.1679 |
79706 | PRKRIP1 | C08 | Human | Oral cavity | OSCC | 4.45e-19 | 4.76e-01 | 0.1919 |
79706 | PRKRIP1 | LN46 | Human | Oral cavity | OSCC | 1.62e-03 | 3.50e-01 | 0.1666 |
79706 | PRKRIP1 | EOLP-1 | Human | Oral cavity | EOLP | 2.51e-03 | 2.03e-01 | -0.0202 |
79706 | PRKRIP1 | SYSMH1 | Human | Oral cavity | OSCC | 1.80e-06 | 1.49e-01 | 0.1127 |
79706 | PRKRIP1 | SYSMH2 | Human | Oral cavity | OSCC | 9.09e-08 | 3.14e-01 | 0.2326 |
79706 | PRKRIP1 | SYSMH3 | Human | Oral cavity | OSCC | 2.86e-07 | 3.28e-01 | 0.2442 |
79706 | PRKRIP1 | SYSMH6 | Human | Oral cavity | OSCC | 3.62e-02 | 1.72e-01 | 0.1275 |
79706 | PRKRIP1 | HTA12-15-2 | Human | Pancreas | PDAC | 3.87e-03 | 3.81e-01 | 0.2315 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:000646910 | Cervix | CC | negative regulation of protein kinase activity | 47/2311 | 212/18723 | 4.13e-05 | 6.36e-04 | 47 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:000838010 | Cervix | CC | RNA splicing | 76/2311 | 434/18723 | 9.79e-04 | 8.19e-03 | 76 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0010563111 | Esophagus | ESCC | negative regulation of phosphorus metabolic process | 274/8552 | 442/18723 | 2.32e-12 | 9.41e-11 | 274 |
GO:0045936111 | Esophagus | ESCC | negative regulation of phosphate metabolic process | 273/8552 | 441/18723 | 3.18e-12 | 1.25e-10 | 273 |
GO:0051348111 | Esophagus | ESCC | negative regulation of transferase activity | 177/8552 | 268/18723 | 1.08e-11 | 4.00e-10 | 177 |
GO:0042326111 | Esophagus | ESCC | negative regulation of phosphorylation | 237/8552 | 385/18723 | 1.86e-10 | 5.33e-09 | 237 |
GO:0001933111 | Esophagus | ESCC | negative regulation of protein phosphorylation | 213/8552 | 342/18723 | 3.54e-10 | 9.76e-09 | 213 |
GO:003367319 | Esophagus | ESCC | negative regulation of kinase activity | 154/8552 | 237/18723 | 1.38e-09 | 3.27e-08 | 154 |
GO:000646920 | Esophagus | ESCC | negative regulation of protein kinase activity | 140/8552 | 212/18723 | 1.53e-09 | 3.56e-08 | 140 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:001056322 | Liver | HCC | negative regulation of phosphorus metabolic process | 259/7958 | 442/18723 | 4.29e-12 | 1.92e-10 | 259 |
GO:004593622 | Liver | HCC | negative regulation of phosphate metabolic process | 258/7958 | 441/18723 | 6.00e-12 | 2.60e-10 | 258 |
GO:004232622 | Liver | HCC | negative regulation of phosphorylation | 227/7958 | 385/18723 | 3.98e-11 | 1.52e-09 | 227 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PRKRIP1 | SNV | Missense_Mutation | c.517N>A | p.Glu173Lys | p.E173K | Q9H875 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PRKRIP1 | SNV | Missense_Mutation | c.284A>G | p.Tyr95Cys | p.Y95C | Q9H875 | protein_coding | deleterious(0.01) | probably_damaging(0.926) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PRKRIP1 | deletion | Frame_Shift_Del | c.69delN | p.Lys25ArgfsTer15 | p.K25Rfs*15 | Q9H875 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
PRKRIP1 | SNV | Missense_Mutation | c.363N>T | p.Glu121Asp | p.E121D | Q9H875 | protein_coding | tolerated(0.1) | benign(0.193) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD | |
PRKRIP1 | SNV | Missense_Mutation | rs367627621 | c.257N>A | p.Arg86His | p.R86H | Q9H875 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PRKRIP1 | SNV | Missense_Mutation | c.496N>T | p.Ala166Ser | p.A166S | Q9H875 | protein_coding | tolerated(0.71) | benign(0.01) | TCGA-44-7667-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PRKRIP1 | SNV | Missense_Mutation | novel | c.269N>T | p.Tyr90Phe | p.Y90F | Q9H875 | protein_coding | deleterious(0) | benign(0.208) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PRKRIP1 | SNV | Missense_Mutation | novel | c.4N>A | p.Ala2Thr | p.A2T | Q9H875 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.588) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
PRKRIP1 | SNV | Missense_Mutation | novel | c.406N>C | p.Glu136Gln | p.E136Q | Q9H875 | protein_coding | tolerated(0.3) | benign(0.137) | TCGA-90-A4EE-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR |
PRKRIP1 | SNV | Missense_Mutation | novel | c.448N>G | p.Lys150Glu | p.K150E | Q9H875 | protein_coding | deleterious_low_confidence(0.01) | benign(0.084) | TCGA-J1-A4AH-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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