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Gene: PLIN3 |
Gene summary for PLIN3 |
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Gene information | Species | Human | Gene symbol | PLIN3 | Gene ID | 10226 |
Gene name | perilipin 3 | |
Gene Alias | M6PRBP1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A140VJN8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10226 | PLIN3 | C06 | Human | Oral cavity | OSCC | 1.34e-08 | 1.56e+00 | 0.2699 |
10226 | PLIN3 | C07 | Human | Oral cavity | OSCC | 7.06e-12 | 1.89e+00 | 0.2491 |
10226 | PLIN3 | C08 | Human | Oral cavity | OSCC | 6.06e-46 | 9.22e-01 | 0.1919 |
10226 | PLIN3 | C09 | Human | Oral cavity | OSCC | 1.75e-11 | 5.10e-01 | 0.1431 |
10226 | PLIN3 | LN22 | Human | Oral cavity | OSCC | 1.40e-03 | 8.47e-01 | 0.1733 |
10226 | PLIN3 | LN46 | Human | Oral cavity | OSCC | 6.23e-07 | 4.79e-01 | 0.1666 |
10226 | PLIN3 | LP15 | Human | Oral cavity | LP | 2.16e-08 | 1.42e+00 | 0.2174 |
10226 | PLIN3 | LP17 | Human | Oral cavity | LP | 2.20e-02 | 8.58e-01 | 0.2349 |
10226 | PLIN3 | SYSMH1 | Human | Oral cavity | OSCC | 3.03e-11 | 3.08e-01 | 0.1127 |
10226 | PLIN3 | SYSMH2 | Human | Oral cavity | OSCC | 1.03e-38 | 1.26e+00 | 0.2326 |
10226 | PLIN3 | SYSMH3 | Human | Oral cavity | OSCC | 3.65e-44 | 1.29e+00 | 0.2442 |
10226 | PLIN3 | SYSMH4 | Human | Oral cavity | OSCC | 7.43e-16 | 2.97e-01 | 0.1226 |
10226 | PLIN3 | SYSMH5 | Human | Oral cavity | OSCC | 7.43e-26 | 1.01e+00 | 0.0647 |
10226 | PLIN3 | SYSMH6 | Human | Oral cavity | OSCC | 2.98e-11 | 5.04e-01 | 0.1275 |
10226 | PLIN3 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 3.34e-14 | 6.32e-01 | -0.1833 |
10226 | PLIN3 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 3.42e-07 | 3.06e-01 | -0.23 |
10226 | PLIN3 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 3.92e-07 | 5.10e-01 | -0.23 |
10226 | PLIN3 | 047563_1562-all-cells | Human | Prostate | BPH | 1.91e-07 | -5.79e-02 | 0.0791 |
10226 | PLIN3 | Dong_P1 | Human | Prostate | Tumor | 2.04e-08 | -4.48e-02 | 0.035 |
10226 | PLIN3 | Dong_P3 | Human | Prostate | Tumor | 1.17e-10 | 1.50e-01 | 0.0278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051235110 | Esophagus | ESCC | maintenance of location | 200/8552 | 327/18723 | 1.01e-08 | 2.02e-07 | 200 |
GO:00199155 | Esophagus | ESCC | lipid storage | 58/8552 | 87/18723 | 6.15e-05 | 4.72e-04 | 58 |
GO:00108836 | Esophagus | ESCC | regulation of lipid storage | 36/8552 | 57/18723 | 5.87e-03 | 2.17e-02 | 36 |
GO:005123511 | Liver | Cirrhotic | maintenance of location | 117/4634 | 327/18723 | 4.78e-06 | 7.86e-05 | 117 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:00108831 | Liver | Cirrhotic | regulation of lipid storage | 26/4634 | 57/18723 | 4.79e-04 | 3.85e-03 | 26 |
GO:00199151 | Liver | Cirrhotic | lipid storage | 35/4634 | 87/18723 | 1.03e-03 | 7.20e-03 | 35 |
GO:19059521 | Liver | Cirrhotic | regulation of lipid localization | 62/4634 | 181/18723 | 2.53e-03 | 1.51e-02 | 62 |
GO:19059541 | Liver | Cirrhotic | positive regulation of lipid localization | 39/4634 | 110/18723 | 7.76e-03 | 3.65e-02 | 39 |
GO:005123521 | Liver | HCC | maintenance of location | 185/7958 | 327/18723 | 1.70e-07 | 3.12e-06 | 185 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:00199152 | Liver | HCC | lipid storage | 53/7958 | 87/18723 | 4.01e-04 | 2.71e-03 | 53 |
GO:00108832 | Liver | HCC | regulation of lipid storage | 35/7958 | 57/18723 | 3.08e-03 | 1.43e-02 | 35 |
GO:005123518 | Oral cavity | OSCC | maintenance of location | 182/7305 | 327/18723 | 6.16e-10 | 1.58e-08 | 182 |
GO:00199154 | Oral cavity | OSCC | lipid storage | 48/7305 | 87/18723 | 1.60e-03 | 7.62e-03 | 48 |
GO:00108835 | Oral cavity | OSCC | regulation of lipid storage | 32/7305 | 57/18723 | 6.45e-03 | 2.40e-02 | 32 |
GO:005123519 | Oral cavity | LP | maintenance of location | 111/4623 | 327/18723 | 9.62e-05 | 1.20e-03 | 111 |
GO:005123516 | Prostate | BPH | maintenance of location | 80/3107 | 327/18723 | 1.55e-04 | 1.36e-03 | 80 |
GO:005123517 | Prostate | Tumor | maintenance of location | 78/3246 | 327/18723 | 1.56e-03 | 9.55e-03 | 78 |
GO:005123527 | Skin | cSCC | maintenance of location | 106/4864 | 327/18723 | 5.17e-03 | 2.61e-02 | 106 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLIN3 | SNV | Missense_Mutation | c.580N>C | p.Gly194Arg | p.G194R | O60664 | protein_coding | deleterious(0.02) | probably_damaging(0.956) | TCGA-E2-A1LA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
PLIN3 | deletion | Frame_Shift_Del | novel | c.454delN | p.Asp152ThrfsTer17 | p.D152Tfs*17 | O60664 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PLIN3 | SNV | Missense_Mutation | rs577339133 | c.856N>A | p.Val286Ile | p.V286I | O60664 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-FU-A3WB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PLIN3 | SNV | Missense_Mutation | c.484N>A | p.Val162Met | p.V162M | O60664 | protein_coding | tolerated(0.17) | benign(0.269) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
PLIN3 | SNV | Missense_Mutation | rs574992524 | c.932N>A | p.Gly311Asp | p.G311D | O60664 | protein_coding | tolerated(0.36) | benign(0.055) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLIN3 | SNV | Missense_Mutation | rs749599909 | c.1244N>T | p.Thr415Met | p.T415M | O60664 | protein_coding | tolerated(0.21) | benign(0.009) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLIN3 | SNV | Missense_Mutation | novel | c.345N>T | p.Glu115Asp | p.E115D | O60664 | protein_coding | tolerated(0.65) | benign(0.01) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
PLIN3 | SNV | Missense_Mutation | rs768566079 | c.1297N>G | p.Lys433Glu | p.K433E | O60664 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PLIN3 | SNV | Missense_Mutation | rs142986276 | c.671N>T | p.Ala224Val | p.A224V | O60664 | protein_coding | tolerated(0.18) | benign(0.08) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PLIN3 | SNV | Missense_Mutation | c.150N>T | p.Lys50Asn | p.K50N | O60664 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
10226 | PLIN3 | NA | IDURSULFASE | IDURSULFASE | ||
10226 | PLIN3 | NA | IDURSULFASE | IDURSULFASE | ||
10226 | PLIN3 | NA | GALSULFASE | GALSULFASE |
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