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Gene: PGM3 |
Gene summary for PGM3 |
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Gene information | Species | Human | Gene symbol | PGM3 | Gene ID | 5238 |
Gene name | phosphoglucomutase 3 | |
Gene Alias | AGM1 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O95394 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5238 | PGM3 | SYSMH1 | Human | Oral cavity | OSCC | 3.62e-13 | 2.99e-01 | 0.1127 |
5238 | PGM3 | SYSMH2 | Human | Oral cavity | OSCC | 4.08e-11 | 3.25e-01 | 0.2326 |
5238 | PGM3 | SYSMH3 | Human | Oral cavity | OSCC | 2.89e-27 | 5.50e-01 | 0.2442 |
5238 | PGM3 | SYSMH5 | Human | Oral cavity | OSCC | 3.61e-08 | 1.86e-01 | 0.0647 |
5238 | PGM3 | SYSMH6 | Human | Oral cavity | OSCC | 4.21e-11 | 3.43e-01 | 0.1275 |
5238 | PGM3 | GSM5252128_BPH327PrGF_Via | Human | Prostate | BPH | 7.18e-04 | 2.25e-01 | -0.1688 |
5238 | PGM3 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 2.58e-11 | 3.81e-01 | -0.1972 |
5238 | PGM3 | GSM5252131_BPH340PrSF_Via | Human | Prostate | BPH | 1.01e-05 | 2.44e-01 | -0.2126 |
5238 | PGM3 | GSM5252132_BPH389PrGF | Human | Prostate | BPH | 6.03e-16 | 8.02e-01 | -0.2247 |
5238 | PGM3 | GSM5252133_BPH389PrSF | Human | Prostate | BPH | 1.72e-02 | 5.35e-01 | -0.2027 |
5238 | PGM3 | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 8.29e-13 | 4.91e-01 | -0.1433 |
5238 | PGM3 | GSM5252135_BPH511PrPUr_Fcol_3GEX | Human | Prostate | BPH | 2.73e-15 | 5.12e-01 | -0.1833 |
5238 | PGM3 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 2.40e-07 | 3.32e-01 | -0.23 |
5238 | PGM3 | GSM5252137_BPH556PrGA2_Fcol | Human | Prostate | BPH | 5.31e-06 | 3.63e-01 | -0.23 |
5238 | PGM3 | 047563_1562-all-cells | Human | Prostate | BPH | 7.57e-07 | 2.22e-01 | 0.0791 |
5238 | PGM3 | 048752_1579-all-cells | Human | Prostate | BPH | 1.35e-19 | 4.55e-01 | 0.1008 |
5238 | PGM3 | 052095_1628-all-cells | Human | Prostate | BPH | 1.67e-02 | 1.56e-01 | 0.1032 |
5238 | PGM3 | 052097_1595-all-cells | Human | Prostate | BPH | 2.54e-20 | 4.97e-01 | 0.0972 |
5238 | PGM3 | 052099_1652-all-cells | Human | Prostate | BPH | 2.65e-13 | 4.43e-01 | 0.1038 |
5238 | PGM3 | Dong_P1 | Human | Prostate | Tumor | 3.24e-02 | -3.65e-02 | 0.035 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000648714 | Esophagus | ESCC | protein N-linked glycosylation | 51/8552 | 65/18723 | 6.41e-08 | 1.13e-06 | 51 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00700854 | Esophagus | ESCC | glycosylation | 144/8552 | 240/18723 | 5.12e-06 | 5.38e-05 | 144 |
GO:00064865 | Esophagus | ESCC | protein glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00434135 | Esophagus | ESCC | macromolecule glycosylation | 135/8552 | 226/18723 | 1.36e-05 | 1.24e-04 | 135 |
GO:00092256 | Esophagus | ESCC | nucleotide-sugar metabolic process | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
GO:00091012 | Esophagus | ESCC | glycoprotein biosynthetic process | 181/8552 | 317/18723 | 2.54e-05 | 2.15e-04 | 181 |
GO:00064931 | Esophagus | ESCC | protein O-linked glycosylation | 51/8552 | 86/18723 | 7.54e-03 | 2.70e-02 | 51 |
GO:00092262 | Esophagus | ESCC | nucleotide-sugar biosynthetic process | 14/8552 | 19/18723 | 1.27e-02 | 4.21e-02 | 14 |
GO:000648711 | Liver | HCC | protein N-linked glycosylation | 48/7958 | 65/18723 | 2.85e-07 | 5.00e-06 | 48 |
GO:00064862 | Liver | HCC | protein glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00434132 | Liver | HCC | macromolecule glycosylation | 122/7958 | 226/18723 | 3.11e-04 | 2.21e-03 | 122 |
GO:00700852 | Liver | HCC | glycosylation | 128/7958 | 240/18723 | 4.35e-04 | 2.92e-03 | 128 |
GO:00092254 | Liver | HCC | nucleotide-sugar metabolic process | 25/7958 | 36/18723 | 9.87e-04 | 5.71e-03 | 25 |
GO:0009100 | Liver | HCC | glycoprotein metabolic process | 193/7958 | 387/18723 | 1.89e-03 | 9.62e-03 | 193 |
GO:00064875 | Oral cavity | OSCC | protein N-linked glycosylation | 44/7305 | 65/18723 | 2.63e-06 | 3.26e-05 | 44 |
GO:00092255 | Oral cavity | OSCC | nucleotide-sugar metabolic process | 26/7305 | 36/18723 | 5.44e-05 | 4.51e-04 | 26 |
GO:00091001 | Oral cavity | OSCC | glycoprotein metabolic process | 185/7305 | 387/18723 | 2.37e-04 | 1.54e-03 | 185 |
GO:00091011 | Oral cavity | OSCC | glycoprotein biosynthetic process | 151/7305 | 317/18723 | 1.01e-03 | 5.26e-03 | 151 |
GO:00064864 | Oral cavity | OSCC | protein glycosylation | 111/7305 | 226/18723 | 1.22e-03 | 6.10e-03 | 111 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012505 | Esophagus | ESCC | Biosynthesis of nucleotide sugars | 28/4205 | 37/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 28 |
hsa005202 | Esophagus | ESCC | Amino sugar and nucleotide sugar metabolism | 35/4205 | 49/8465 | 1.60e-03 | 4.88e-03 | 2.50e-03 | 35 |
hsa0125012 | Esophagus | ESCC | Biosynthesis of nucleotide sugars | 28/4205 | 37/8465 | 1.10e-03 | 3.42e-03 | 1.75e-03 | 28 |
hsa0052011 | Esophagus | ESCC | Amino sugar and nucleotide sugar metabolism | 35/4205 | 49/8465 | 1.60e-03 | 4.88e-03 | 2.50e-03 | 35 |
hsa00520 | Oral cavity | OSCC | Amino sugar and nucleotide sugar metabolism | 34/3704 | 49/8465 | 2.48e-04 | 8.08e-04 | 4.11e-04 | 34 |
hsa012504 | Oral cavity | OSCC | Biosynthesis of nucleotide sugars | 25/3704 | 37/8465 | 2.93e-03 | 7.49e-03 | 3.81e-03 | 25 |
hsa005201 | Oral cavity | OSCC | Amino sugar and nucleotide sugar metabolism | 34/3704 | 49/8465 | 2.48e-04 | 8.08e-04 | 4.11e-04 | 34 |
hsa0125011 | Oral cavity | OSCC | Biosynthesis of nucleotide sugars | 25/3704 | 37/8465 | 2.93e-03 | 7.49e-03 | 3.81e-03 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PGM3 | SNV | Missense_Mutation | c.497A>C | p.Gln166Pro | p.Q166P | O95394 | protein_coding | deleterious(0.04) | possibly_damaging(0.832) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PGM3 | SNV | Missense_Mutation | c.421N>C | p.Glu141Gln | p.E141Q | O95394 | protein_coding | tolerated(0.32) | benign(0.071) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PGM3 | insertion | Frame_Shift_Ins | novel | c.398_399insTCAGATACCA | p.Leu134GlnfsTer6 | p.L134Qfs*6 | O95394 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
PGM3 | SNV | Missense_Mutation | c.385N>A | p.Asp129Asn | p.D129N | O95394 | protein_coding | tolerated(0.11) | benign(0.076) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
PGM3 | SNV | Missense_Mutation | novel | c.1531N>T | p.Asp511Tyr | p.D511Y | O95394 | protein_coding | deleterious(0.01) | possibly_damaging(0.544) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PGM3 | SNV | Missense_Mutation | novel | c.872N>A | p.Gly291Glu | p.G291E | O95394 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PGM3 | SNV | Missense_Mutation | c.244N>C | p.Lys82Gln | p.K82Q | O95394 | protein_coding | tolerated(0.33) | benign(0.044) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PGM3 | SNV | Missense_Mutation | c.583N>C | p.Tyr195His | p.Y195H | O95394 | protein_coding | tolerated(0.52) | possibly_damaging(0.663) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PGM3 | SNV | Missense_Mutation | c.1676C>A | p.Ala559Asp | p.A559D | O95394 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-A014-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PGM3 | SNV | Missense_Mutation | c.431N>G | p.Asn144Ser | p.N144S | O95394 | protein_coding | tolerated(0.09) | benign(0.011) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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