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Gene: PEX2 |
Gene summary for PEX2 |
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Gene information | Species | Human | Gene symbol | PEX2 | Gene ID | 5828 |
Gene name | peroxisomal biogenesis factor 2 | |
Gene Alias | PAF1 | |
Cytomap | 8q21.13 | |
Gene Type | protein-coding | GO ID | GO:0000038 | UniProtAcc | P28328 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5828 | PEX2 | C30 | Human | Oral cavity | OSCC | 3.22e-31 | 1.56e+00 | 0.3055 |
5828 | PEX2 | C38 | Human | Oral cavity | OSCC | 2.93e-06 | 1.00e+00 | 0.172 |
5828 | PEX2 | C43 | Human | Oral cavity | OSCC | 1.19e-27 | 5.61e-01 | 0.1704 |
5828 | PEX2 | C46 | Human | Oral cavity | OSCC | 1.59e-21 | 6.67e-01 | 0.1673 |
5828 | PEX2 | C51 | Human | Oral cavity | OSCC | 1.02e-12 | 9.60e-01 | 0.2674 |
5828 | PEX2 | C57 | Human | Oral cavity | OSCC | 2.81e-23 | 8.55e-01 | 0.1679 |
5828 | PEX2 | C06 | Human | Oral cavity | OSCC | 1.76e-04 | 1.01e+00 | 0.2699 |
5828 | PEX2 | C08 | Human | Oral cavity | OSCC | 5.01e-43 | 8.07e-01 | 0.1919 |
5828 | PEX2 | C09 | Human | Oral cavity | OSCC | 1.63e-03 | 3.45e-01 | 0.1431 |
5828 | PEX2 | LN22 | Human | Oral cavity | OSCC | 4.67e-05 | 1.08e+00 | 0.1733 |
5828 | PEX2 | LN46 | Human | Oral cavity | OSCC | 1.04e-06 | 5.73e-01 | 0.1666 |
5828 | PEX2 | LP15 | Human | Oral cavity | LP | 2.13e-07 | 1.16e+00 | 0.2174 |
5828 | PEX2 | LP17 | Human | Oral cavity | LP | 6.05e-03 | 8.08e-01 | 0.2349 |
5828 | PEX2 | SYSMH1 | Human | Oral cavity | OSCC | 1.16e-13 | 3.40e-01 | 0.1127 |
5828 | PEX2 | SYSMH2 | Human | Oral cavity | OSCC | 1.40e-20 | 6.41e-01 | 0.2326 |
5828 | PEX2 | SYSMH3 | Human | Oral cavity | OSCC | 4.43e-19 | 5.49e-01 | 0.2442 |
5828 | PEX2 | SYSMH4 | Human | Oral cavity | OSCC | 2.92e-04 | 1.11e-01 | 0.1226 |
5828 | PEX2 | SYSMH5 | Human | Oral cavity | OSCC | 6.70e-05 | 1.62e-01 | 0.0647 |
5828 | PEX2 | SYSMH6 | Human | Oral cavity | OSCC | 3.91e-09 | 3.47e-01 | 0.1275 |
5828 | PEX2 | P1_cSCC | Human | Skin | cSCC | 7.26e-20 | 6.12e-01 | 0.0292 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0006605 | Colorectum | AD | protein targeting | 105/3918 | 314/18723 | 1.39e-07 | 6.44e-06 | 105 |
GO:0017038 | Colorectum | AD | protein import | 67/3918 | 206/18723 | 6.34e-05 | 1.05e-03 | 67 |
GO:0071806 | Colorectum | AD | protein transmembrane transport | 21/3918 | 59/18723 | 6.58e-03 | 4.08e-02 | 21 |
GO:00725941 | Colorectum | SER | establishment of protein localization to organelle | 111/2897 | 422/18723 | 4.98e-09 | 4.49e-07 | 111 |
GO:00901501 | Colorectum | SER | establishment of protein localization to membrane | 68/2897 | 260/18723 | 5.55e-06 | 2.01e-04 | 68 |
GO:00066051 | Colorectum | SER | protein targeting | 76/2897 | 314/18723 | 3.19e-05 | 8.47e-04 | 76 |
GO:00170381 | Colorectum | SER | protein import | 49/2897 | 206/18723 | 1.12e-03 | 1.29e-02 | 49 |
GO:00718061 | Colorectum | SER | protein transmembrane transport | 17/2897 | 59/18723 | 6.64e-03 | 4.69e-02 | 17 |
GO:00901504 | Colorectum | FAP | establishment of protein localization to membrane | 69/2622 | 260/18723 | 6.40e-08 | 4.54e-06 | 69 |
GO:00725944 | Colorectum | FAP | establishment of protein localization to organelle | 96/2622 | 422/18723 | 6.63e-07 | 3.20e-05 | 96 |
GO:00066054 | Colorectum | FAP | protein targeting | 74/2622 | 314/18723 | 3.21e-06 | 1.17e-04 | 74 |
GO:00170384 | Colorectum | FAP | protein import | 47/2622 | 206/18723 | 4.10e-04 | 4.94e-03 | 47 |
GO:0006612 | Colorectum | FAP | protein targeting to membrane | 30/2622 | 131/18723 | 3.95e-03 | 2.75e-02 | 30 |
GO:00650021 | Colorectum | FAP | intracellular protein transmembrane transport | 14/2622 | 51/18723 | 8.70e-03 | 4.98e-02 | 14 |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0090150110 | Esophagus | ESCC | establishment of protein localization to membrane | 182/8552 | 260/18723 | 1.27e-15 | 8.19e-14 | 182 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa041467 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa0414612 | Esophagus | ESCC | Peroxisome | 55/4205 | 82/8465 | 1.04e-03 | 3.27e-03 | 1.68e-03 | 55 |
hsa041462 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa041463 | Liver | Cirrhotic | Peroxisome | 36/2530 | 82/8465 | 4.79e-03 | 1.74e-02 | 1.07e-02 | 36 |
hsa041464 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041465 | Liver | HCC | Peroxisome | 58/4020 | 82/8465 | 1.57e-05 | 1.05e-04 | 5.85e-05 | 58 |
hsa041466 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414611 | Oral cavity | OSCC | Peroxisome | 47/3704 | 82/8465 | 9.01e-03 | 2.01e-02 | 1.03e-02 | 47 |
hsa0414621 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
hsa0414631 | Oral cavity | LP | Peroxisome | 33/2418 | 82/8465 | 1.48e-02 | 4.69e-02 | 3.03e-02 | 33 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PEX2 | SNV | Missense_Mutation | rs564144139 | c.506N>A | p.Arg169His | p.R169H | P28328 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A7-A13F-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
PEX2 | SNV | Missense_Mutation | c.904N>A | p.Val302Ile | p.V302I | P28328 | protein_coding | tolerated_low_confidence(0.22) | benign(0.084) | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
PEX2 | SNV | Missense_Mutation | c.220G>T | p.Ala74Ser | p.A74S | P28328 | protein_coding | tolerated(0.13) | probably_damaging(0.976) | TCGA-AA-3660-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PEX2 | SNV | Missense_Mutation | rs747866716 | c.205N>G | p.Ile69Val | p.I69V | P28328 | protein_coding | tolerated(0.92) | benign(0.007) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PEX2 | SNV | Missense_Mutation | rs199845625 | c.374N>A | p.Arg125Gln | p.R125Q | P28328 | protein_coding | tolerated(0.52) | benign(0.167) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PEX2 | SNV | Missense_Mutation | novel | c.460N>G | p.Phe154Val | p.F154V | P28328 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PEX2 | SNV | Missense_Mutation | c.589N>C | p.Trp197Arg | p.W197R | P28328 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PEX2 | SNV | Missense_Mutation | rs544763390 | c.892G>A | p.Glu298Lys | p.E298K | P28328 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.557) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PEX2 | SNV | Missense_Mutation | c.126N>A | p.His42Gln | p.H42Q | P28328 | protein_coding | tolerated(1) | benign(0.01) | TCGA-EI-6513-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PEX2 | deletion | Frame_Shift_Del | c.268delT | p.Ser90ProfsTer4 | p.S90Pfs*4 | P28328 | protein_coding | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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