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Gene: PDE6D |
Gene summary for PDE6D |
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Gene information | Species | Human | Gene symbol | PDE6D | Gene ID | 5147 |
Gene name | phosphodiesterase 6D | |
Gene Alias | JBTS22 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | B8ZZK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5147 | PDE6D | C09 | Human | Oral cavity | OSCC | 4.01e-09 | 3.15e-01 | 0.1431 |
5147 | PDE6D | LN38 | Human | Oral cavity | OSCC | 1.62e-03 | 7.24e-01 | 0.168 |
5147 | PDE6D | LN46 | Human | Oral cavity | OSCC | 2.26e-07 | 3.82e-01 | 0.1666 |
5147 | PDE6D | LP17 | Human | Oral cavity | LP | 1.33e-03 | 5.16e-01 | 0.2349 |
5147 | PDE6D | EOLP-1 | Human | Oral cavity | EOLP | 1.16e-03 | 1.36e-01 | -0.0202 |
5147 | PDE6D | SYSMH1 | Human | Oral cavity | OSCC | 9.38e-04 | 3.77e-02 | 0.1127 |
5147 | PDE6D | SYSMH2 | Human | Oral cavity | OSCC | 3.15e-07 | 1.10e-01 | 0.2326 |
5147 | PDE6D | SYSMH3 | Human | Oral cavity | OSCC | 1.69e-07 | 2.03e-01 | 0.2442 |
5147 | PDE6D | SYSMH6 | Human | Oral cavity | OSCC | 4.87e-05 | 3.81e-02 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE6D | SNV | Missense_Mutation | c.106G>A | p.Glu36Lys | p.E36K | O43924 | protein_coding | tolerated(0.29) | benign(0.028) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD | |
PDE6D | insertion | Nonsense_Mutation | novel | c.178_179insTTATTTTATTTTTTTAAAAAACA | p.Ser60PhefsTer6 | p.S60Ffs*6 | O43924 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PDE6D | SNV | Missense_Mutation | c.16G>C | p.Glu6Gln | p.E6Q | O43924 | protein_coding | tolerated(0.41) | benign(0) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
PDE6D | SNV | Missense_Mutation | c.200C>T | p.Ser67Leu | p.S67L | O43924 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PDE6D | SNV | Missense_Mutation | c.158N>A | p.Ile53Asn | p.I53N | O43924 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EI-6511-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatinum+5-fu | SD | |
PDE6D | SNV | Missense_Mutation | c.380N>C | p.Val127Ala | p.V127A | O43924 | protein_coding | deleterious(0) | possibly_damaging(0.669) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PDE6D | SNV | Missense_Mutation | rs767716256 | c.143N>A | p.Arg48His | p.R48H | O43924 | protein_coding | tolerated(0.34) | benign(0.01) | TCGA-D1-A167-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDE6D | SNV | Missense_Mutation | rs758019119 | c.223N>T | p.Arg75Cys | p.R75C | O43924 | protein_coding | deleterious(0.05) | benign(0.303) | TCGA-EJ-A7NN-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | PD |
PDE6D | SNV | Missense_Mutation | c.385A>G | p.Ile129Val | p.I129V | O43924 | protein_coding | tolerated(0.16) | benign(0.076) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5147 | PDE6D | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL628 | PENTOXIFYLLINE | |
5147 | PDE6D | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL932 | DIPYRIDAMOLE |
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