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Gene: PDCD6 |
Gene summary for PDCD6 |
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Gene information | Species | Human | Gene symbol | PDCD6 | Gene ID | 10016 |
Gene name | programmed cell death 6 | |
Gene Alias | ALG-2 | |
Cytomap | 5p15.33 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | O75340 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10016 | PDCD6 | A018-E-020 | Human | Colorectum | FAP | 3.32e-07 | -1.87e-01 | -0.2034 |
10016 | PDCD6 | F034 | Human | Colorectum | FAP | 1.24e-11 | -9.76e-02 | -0.0665 |
10016 | PDCD6 | CRC-1-8810 | Human | Colorectum | CRC | 1.49e-03 | -1.82e-01 | 0.6257 |
10016 | PDCD6 | CRC-3-11773 | Human | Colorectum | CRC | 5.54e-07 | -1.43e-01 | 0.2564 |
10016 | PDCD6 | AEH-subject1 | Human | Endometrium | AEH | 3.31e-11 | -2.71e-01 | -0.3059 |
10016 | PDCD6 | AEH-subject2 | Human | Endometrium | AEH | 5.16e-11 | -2.04e-01 | -0.2525 |
10016 | PDCD6 | AEH-subject3 | Human | Endometrium | AEH | 2.14e-11 | -1.95e-01 | -0.2576 |
10016 | PDCD6 | AEH-subject4 | Human | Endometrium | AEH | 5.75e-08 | -1.86e-01 | -0.2657 |
10016 | PDCD6 | AEH-subject5 | Human | Endometrium | AEH | 3.86e-03 | -2.10e-01 | -0.2953 |
10016 | PDCD6 | EEC-subject1 | Human | Endometrium | EEC | 3.71e-12 | -2.21e-01 | -0.2682 |
10016 | PDCD6 | EEC-subject2 | Human | Endometrium | EEC | 3.56e-11 | -2.88e-01 | -0.2607 |
10016 | PDCD6 | EEC-subject3 | Human | Endometrium | EEC | 4.64e-26 | -4.08e-01 | -0.2525 |
10016 | PDCD6 | EEC-subject4 | Human | Endometrium | EEC | 1.13e-03 | -1.36e-01 | -0.2571 |
10016 | PDCD6 | EEC-subject5 | Human | Endometrium | EEC | 6.21e-07 | -2.37e-01 | -0.249 |
10016 | PDCD6 | GSM5276934 | Human | Endometrium | EEC | 1.91e-03 | -2.27e-01 | -0.0913 |
10016 | PDCD6 | GSM5276935 | Human | Endometrium | EEC | 1.21e-03 | 2.06e-01 | -0.123 |
10016 | PDCD6 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 8.16e-38 | -3.06e-01 | -0.1869 |
10016 | PDCD6 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 9.90e-46 | -1.83e-01 | -0.1875 |
10016 | PDCD6 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.91e-48 | -6.80e-02 | -0.1883 |
10016 | PDCD6 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 6.34e-33 | -1.05e-01 | -0.1934 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525479 | Breast | Precancer | regulation of peptidase activity | 71/1080 | 461/18723 | 2.72e-14 | 6.94e-12 | 71 |
GO:00525489 | Breast | Precancer | regulation of endopeptidase activity | 67/1080 | 432/18723 | 1.06e-13 | 2.36e-11 | 67 |
GO:20001169 | Breast | Precancer | regulation of cysteine-type endopeptidase activity | 43/1080 | 235/18723 | 1.30e-11 | 1.83e-09 | 43 |
GO:00432819 | Breast | Precancer | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 40/1080 | 209/18723 | 1.59e-11 | 2.07e-09 | 40 |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:19033209 | Breast | Precancer | regulation of protein modification by small protein conjugation or removal | 38/1080 | 242/18723 | 1.71e-08 | 1.17e-06 | 38 |
GO:00109529 | Breast | Precancer | positive regulation of peptidase activity | 33/1080 | 197/18723 | 3.01e-08 | 1.89e-06 | 33 |
GO:00313969 | Breast | Precancer | regulation of protein ubiquitination | 33/1080 | 210/18723 | 1.45e-07 | 7.82e-06 | 33 |
GO:00432808 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | 24/1080 | 129/18723 | 3.13e-07 | 1.50e-05 | 24 |
GO:00100389 | Breast | Precancer | response to metal ion | 47/1080 | 373/18723 | 3.88e-07 | 1.79e-05 | 47 |
GO:00109509 | Breast | Precancer | positive regulation of endopeptidase activity | 29/1080 | 179/18723 | 4.23e-07 | 1.90e-05 | 29 |
GO:20010568 | Breast | Precancer | positive regulation of cysteine-type endopeptidase activity | 25/1080 | 148/18723 | 1.19e-06 | 4.60e-05 | 25 |
GO:00092667 | Breast | Precancer | response to temperature stimulus | 27/1080 | 178/18723 | 3.85e-06 | 1.21e-04 | 27 |
GO:00346059 | Breast | Precancer | cellular response to heat | 15/1080 | 69/18723 | 7.08e-06 | 1.95e-04 | 15 |
GO:00106348 | Breast | Precancer | positive regulation of epithelial cell migration | 25/1080 | 176/18723 | 2.75e-05 | 6.21e-04 | 25 |
GO:00106319 | Breast | Precancer | epithelial cell migration | 40/1080 | 357/18723 | 4.57e-05 | 9.71e-04 | 40 |
GO:00901329 | Breast | Precancer | epithelium migration | 40/1080 | 360/18723 | 5.51e-05 | 1.14e-03 | 40 |
GO:00094088 | Breast | Precancer | response to heat | 18/1080 | 110/18723 | 5.57e-05 | 1.15e-03 | 18 |
GO:00506736 | Breast | Precancer | epithelial cell proliferation | 46/1080 | 437/18723 | 6.02e-05 | 1.23e-03 | 46 |
GO:00435426 | Breast | Precancer | endothelial cell migration | 33/1080 | 279/18723 | 7.28e-05 | 1.44e-03 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDCD6 | SNV | Missense_Mutation | novel | c.154N>G | p.Leu52Val | p.L52V | O75340 | protein_coding | deleterious(0) | possibly_damaging(0.544) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PDCD6 | deletion | Frame_Shift_Del | c.221delG | p.Arg74LeufsTer7 | p.R74Lfs*7 | O75340 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PDCD6 | SNV | Missense_Mutation | rs370878298 | c.541N>A | p.Glu181Lys | p.E181K | O75340 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | rs545985005 | c.302C>T | p.Thr101Met | p.T101M | O75340 | protein_coding | tolerated(0.08) | benign(0.262) | TCGA-VS-A8QC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
PDCD6 | SNV | Missense_Mutation | rs139334790 | c.500N>A | p.Arg167His | p.R167H | O75340 | protein_coding | deleterious(0.05) | benign(0.017) | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | c.235N>A | p.Gly79Ser | p.G79S | O75340 | protein_coding | tolerated(0.22) | benign(0.015) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PDCD6 | SNV | Missense_Mutation | rs767684079 | c.427C>T | p.Arg143Trp | p.R143W | O75340 | protein_coding | deleterious(0.03) | possibly_damaging(0.85) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | rs373052818 | c.367N>A | p.Gly123Ser | p.G123S | O75340 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3939-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | novel | c.448N>A | p.Asp150Asn | p.D150N | O75340 | protein_coding | tolerated(0.22) | possibly_damaging(0.852) | TCGA-AD-6548-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDCD6 | SNV | Missense_Mutation | rs139334790 | c.500N>A | p.Arg167His | p.R167H | O75340 | protein_coding | deleterious(0.05) | benign(0.017) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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