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Gene: NOSIP |
Gene summary for NOSIP |
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Gene information | Species | Human | Gene symbol | NOSIP | Gene ID | 51070 |
Gene name | nitric oxide synthase interacting protein | |
Gene Alias | CGI-25 | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9Y314 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51070 | NOSIP | P104T-E | Human | Esophagus | ESCC | 1.50e-06 | 6.88e-01 | 0.0931 |
51070 | NOSIP | P107T-E | Human | Esophagus | ESCC | 2.42e-78 | 1.72e+00 | 0.171 |
51070 | NOSIP | P126T-E | Human | Esophagus | ESCC | 1.38e-13 | 1.37e+00 | 0.1125 |
51070 | NOSIP | P127T-E | Human | Esophagus | ESCC | 4.03e-31 | 5.40e-01 | 0.0826 |
51070 | NOSIP | P128T-E | Human | Esophagus | ESCC | 1.05e-66 | 2.26e+00 | 0.1241 |
51070 | NOSIP | P130T-E | Human | Esophagus | ESCC | 3.68e-62 | 1.46e+00 | 0.1676 |
51070 | NOSIP | S43 | Human | Liver | Cirrhotic | 2.05e-04 | -2.33e-01 | -0.0187 |
51070 | NOSIP | HCC1_Meng | Human | Liver | HCC | 3.16e-101 | 1.14e-01 | 0.0246 |
51070 | NOSIP | HCC2_Meng | Human | Liver | HCC | 2.47e-43 | 1.11e-01 | 0.0107 |
51070 | NOSIP | cirrhotic1 | Human | Liver | Cirrhotic | 1.33e-21 | 2.64e-01 | 0.0202 |
51070 | NOSIP | cirrhotic2 | Human | Liver | Cirrhotic | 1.93e-12 | 2.30e-01 | 0.0201 |
51070 | NOSIP | cirrhotic3 | Human | Liver | Cirrhotic | 1.31e-05 | 1.58e-01 | 0.0215 |
51070 | NOSIP | HCC1 | Human | Liver | HCC | 3.97e-05 | 4.53e+00 | 0.5336 |
51070 | NOSIP | HCC2 | Human | Liver | HCC | 1.89e-03 | 4.45e+00 | 0.5341 |
51070 | NOSIP | Pt13.b | Human | Liver | HCC | 1.57e-17 | 2.36e-01 | 0.0251 |
51070 | NOSIP | Pt14.b | Human | Liver | HCC | 5.08e-07 | 3.04e-01 | 0.018 |
51070 | NOSIP | S014 | Human | Liver | HCC | 2.29e-20 | 9.60e-01 | 0.2254 |
51070 | NOSIP | S015 | Human | Liver | HCC | 1.13e-21 | 1.29e+00 | 0.2375 |
51070 | NOSIP | S016 | Human | Liver | HCC | 4.74e-23 | 1.00e+00 | 0.2243 |
51070 | NOSIP | S027 | Human | Liver | HCC | 1.35e-12 | 9.79e-01 | 0.2446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051341 | Colorectum | SER | regulation of oxidoreductase activity | 27/2897 | 107/18723 | 5.86e-03 | 4.29e-02 | 27 |
GO:00509991 | Thyroid | PTC | regulation of nitric-oxide synthase activity | 22/5968 | 44/18723 | 9.27e-03 | 3.82e-02 | 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOSIP | SNV | Missense_Mutation | c.299N>C | p.Lys100Thr | p.K100T | Q9Y314 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
NOSIP | deletion | In_Frame_Del | novel | c.114_131delTGCCGTGAAGGACTTCGA | p.Ala39_Asp44del | p.A39_D44del | Q9Y314 | protein_coding | TCGA-EW-A3U0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | ||
NOSIP | SNV | Missense_Mutation | rs769816516 | c.334C>T | p.Arg112Trp | p.R112W | Q9Y314 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NOSIP | SNV | Missense_Mutation | c.394A>C | p.Lys132Gln | p.K132Q | Q9Y314 | protein_coding | tolerated(0.24) | benign(0.154) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOSIP | SNV | Missense_Mutation | novel | c.887N>A | p.Arg296Gln | p.R296Q | Q9Y314 | protein_coding | deleterious(0.02) | probably_damaging(0.963) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NOSIP | SNV | Missense_Mutation | rs769816516 | c.334N>T | p.Arg112Trp | p.R112W | Q9Y314 | protein_coding | deleterious(0) | possibly_damaging(0.837) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NOSIP | SNV | Missense_Mutation | rs376400410 | c.545N>T | p.Thr182Met | p.T182M | Q9Y314 | protein_coding | deleterious(0.03) | possibly_damaging(0.577) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NOSIP | SNV | Missense_Mutation | c.68N>T | p.Thr23Ile | p.T23I | Q9Y314 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOSIP | SNV | Missense_Mutation | c.284N>A | p.Arg95Gln | p.R95Q | Q9Y314 | protein_coding | tolerated(0.39) | benign(0.001) | TCGA-EI-6510-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOSIP | SNV | Missense_Mutation | rs767271460 | c.649N>T | p.Arg217Cys | p.R217C | Q9Y314 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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