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Gene: NOP58 |
Gene summary for NOP58 |
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Gene information | Species | Human | Gene symbol | NOP58 | Gene ID | 51602 |
Gene name | NOP58 ribonucleoprotein | |
Gene Alias | HSPC120 | |
Cytomap | 2q33.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9Y2X3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51602 | NOP58 | C21 | Human | Oral cavity | OSCC | 1.13e-44 | 1.93e+00 | 0.2678 |
51602 | NOP58 | C30 | Human | Oral cavity | OSCC | 1.95e-31 | 1.73e+00 | 0.3055 |
51602 | NOP58 | C38 | Human | Oral cavity | OSCC | 8.72e-15 | 1.78e+00 | 0.172 |
51602 | NOP58 | C43 | Human | Oral cavity | OSCC | 2.72e-51 | 1.16e+00 | 0.1704 |
51602 | NOP58 | C46 | Human | Oral cavity | OSCC | 1.94e-32 | 1.02e+00 | 0.1673 |
51602 | NOP58 | C51 | Human | Oral cavity | OSCC | 2.30e-12 | 1.08e+00 | 0.2674 |
51602 | NOP58 | C57 | Human | Oral cavity | OSCC | 4.71e-15 | 9.33e-01 | 0.1679 |
51602 | NOP58 | C06 | Human | Oral cavity | OSCC | 2.27e-06 | 1.57e+00 | 0.2699 |
51602 | NOP58 | C08 | Human | Oral cavity | OSCC | 5.69e-26 | 7.80e-01 | 0.1919 |
51602 | NOP58 | LN22 | Human | Oral cavity | OSCC | 5.98e-13 | 1.44e+00 | 0.1733 |
51602 | NOP58 | LN46 | Human | Oral cavity | OSCC | 5.52e-19 | 1.01e+00 | 0.1666 |
51602 | NOP58 | LP17 | Human | Oral cavity | LP | 2.16e-03 | 8.78e-01 | 0.2349 |
51602 | NOP58 | EOLP-1 | Human | Oral cavity | EOLP | 3.75e-05 | 4.41e-01 | -0.0202 |
51602 | NOP58 | EOLP-2 | Human | Oral cavity | EOLP | 2.08e-04 | 3.14e-01 | -0.0203 |
51602 | NOP58 | NEOLP-2 | Human | Oral cavity | NEOLP | 1.02e-05 | 3.71e-01 | -0.0196 |
51602 | NOP58 | NEOLP-3 | Human | Oral cavity | NEOLP | 3.79e-05 | 3.56e-01 | -0.0191 |
51602 | NOP58 | SYSMH2 | Human | Oral cavity | OSCC | 3.77e-13 | 7.25e-01 | 0.2326 |
51602 | NOP58 | SYSMH3 | Human | Oral cavity | OSCC | 6.27e-25 | 8.83e-01 | 0.2442 |
51602 | NOP58 | SYSMH5 | Human | Oral cavity | OSCC | 4.04e-03 | 3.26e-01 | 0.0647 |
51602 | NOP58 | P1_S1_AK | Human | Skin | AK | 2.40e-13 | 5.05e-01 | -0.3399 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261327 | Esophagus | HGIN | ribonucleoprotein complex biogenesis | 158/2587 | 463/18723 | 2.61e-29 | 5.23e-26 | 158 |
GO:004225426 | Esophagus | HGIN | ribosome biogenesis | 101/2587 | 299/18723 | 8.74e-19 | 4.03e-16 | 101 |
GO:000640320 | Esophagus | HGIN | RNA localization | 66/2587 | 201/18723 | 4.06e-12 | 5.41e-10 | 66 |
GO:001607219 | Esophagus | HGIN | rRNA metabolic process | 72/2587 | 236/18723 | 2.26e-11 | 2.56e-09 | 72 |
GO:000636419 | Esophagus | HGIN | rRNA processing | 69/2587 | 225/18723 | 4.53e-11 | 5.04e-09 | 69 |
GO:003447010 | Esophagus | HGIN | ncRNA processing | 97/2587 | 395/18723 | 5.92e-09 | 3.90e-07 | 97 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:00226137 | Liver | NAFLD | ribonucleoprotein complex biogenesis | 76/1882 | 463/18723 | 1.19e-05 | 3.67e-04 | 76 |
GO:00422547 | Liver | NAFLD | ribosome biogenesis | 52/1882 | 299/18723 | 6.03e-05 | 1.32e-03 | 52 |
GO:00344704 | Liver | NAFLD | ncRNA processing | 57/1882 | 395/18723 | 3.34e-03 | 2.93e-02 | 57 |
GO:00064037 | Liver | NAFLD | RNA localization | 32/1882 | 201/18723 | 5.96e-03 | 4.48e-02 | 32 |
GO:00063644 | Liver | NAFLD | rRNA processing | 35/1882 | 225/18723 | 6.04e-03 | 4.54e-02 | 35 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NOP58 | SNV | Missense_Mutation | novel | c.1187N>C | p.Arg396Thr | p.R396T | Q9Y2X3 | protein_coding | deleterious(0) | benign(0.439) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD |
NOP58 | SNV | Missense_Mutation | c.67N>G | p.Gln23Glu | p.Q23E | Q9Y2X3 | protein_coding | tolerated(0.63) | benign(0.017) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
NOP58 | SNV | Missense_Mutation | c.348N>A | p.Met116Ile | p.M116I | Q9Y2X3 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NOP58 | insertion | Frame_Shift_Ins | novel | c.1320_1321insA | p.Arg443ThrfsTer8 | p.R443Tfs*8 | Q9Y2X3 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
NOP58 | SNV | Missense_Mutation | c.919N>C | p.Asn307His | p.N307H | Q9Y2X3 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NOP58 | SNV | Missense_Mutation | c.1100N>G | p.Val367Gly | p.V367G | Q9Y2X3 | protein_coding | deleterious(0) | benign(0.102) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
NOP58 | SNV | Missense_Mutation | c.563N>A | p.Gly188Asp | p.G188D | Q9Y2X3 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
NOP58 | SNV | Missense_Mutation | c.1079G>A | p.Arg360Gln | p.R360Q | Q9Y2X3 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
NOP58 | SNV | Missense_Mutation | rs755969953 | c.359N>A | p.Arg120His | p.R120H | Q9Y2X3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
NOP58 | SNV | Missense_Mutation | c.1531N>A | p.Ala511Thr | p.A511T | Q9Y2X3 | protein_coding | tolerated(0.4) | benign(0) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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