![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: NAE1 |
Gene summary for NAE1 |
![]() |
Gene information | Species | Human | Gene symbol | NAE1 | Gene ID | 8883 |
Gene name | NEDD8 activating enzyme E1 subunit 1 | |
Gene Alias | A-116A10.1 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q13564 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8883 | NAE1 | C30 | Human | Oral cavity | OSCC | 1.54e-21 | 1.35e+00 | 0.3055 |
8883 | NAE1 | C38 | Human | Oral cavity | OSCC | 3.82e-08 | 1.16e+00 | 0.172 |
8883 | NAE1 | C43 | Human | Oral cavity | OSCC | 2.49e-11 | 2.62e-01 | 0.1704 |
8883 | NAE1 | C46 | Human | Oral cavity | OSCC | 3.22e-25 | 6.97e-01 | 0.1673 |
8883 | NAE1 | C51 | Human | Oral cavity | OSCC | 2.33e-10 | 8.37e-01 | 0.2674 |
8883 | NAE1 | C57 | Human | Oral cavity | OSCC | 1.25e-02 | 4.05e-01 | 0.1679 |
8883 | NAE1 | C06 | Human | Oral cavity | OSCC | 1.85e-02 | 9.42e-01 | 0.2699 |
8883 | NAE1 | C07 | Human | Oral cavity | OSCC | 1.67e-02 | 8.81e-01 | 0.2491 |
8883 | NAE1 | C08 | Human | Oral cavity | OSCC | 3.32e-36 | 8.58e-01 | 0.1919 |
8883 | NAE1 | C09 | Human | Oral cavity | OSCC | 4.81e-05 | 2.99e-01 | 0.1431 |
8883 | NAE1 | LN46 | Human | Oral cavity | OSCC | 5.14e-12 | 7.30e-01 | 0.1666 |
8883 | NAE1 | LP15 | Human | Oral cavity | LP | 7.33e-03 | 1.10e+00 | 0.2174 |
8883 | NAE1 | LP17 | Human | Oral cavity | LP | 3.18e-02 | 7.73e-01 | 0.2349 |
8883 | NAE1 | SYSMH1 | Human | Oral cavity | OSCC | 1.31e-16 | 3.99e-01 | 0.1127 |
8883 | NAE1 | SYSMH2 | Human | Oral cavity | OSCC | 4.90e-28 | 9.45e-01 | 0.2326 |
8883 | NAE1 | SYSMH3 | Human | Oral cavity | OSCC | 1.95e-32 | 8.83e-01 | 0.2442 |
8883 | NAE1 | SYSMH4 | Human | Oral cavity | OSCC | 2.89e-07 | 1.43e-01 | 0.1226 |
8883 | NAE1 | SYSMH5 | Human | Oral cavity | OSCC | 3.02e-11 | 3.71e-01 | 0.0647 |
8883 | NAE1 | SYSMH6 | Human | Oral cavity | OSCC | 1.33e-08 | 3.89e-01 | 0.1275 |
8883 | NAE1 | P4_S8_cSCC | Human | Skin | cSCC | 1.56e-07 | 1.82e-01 | -0.3095 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
GO:000734615 | Esophagus | ESCC | regulation of mitotic cell cycle | 293/8552 | 457/18723 | 8.00e-16 | 5.64e-14 | 293 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:190199013 | Esophagus | ESCC | regulation of mitotic cell cycle phase transition | 191/8552 | 299/18723 | 1.35e-10 | 3.94e-09 | 191 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:00448394 | Esophagus | ESCC | cell cycle G2/M phase transition | 103/8552 | 148/18723 | 3.09e-09 | 6.67e-08 | 103 |
GO:00000864 | Esophagus | ESCC | G2/M transition of mitotic cell cycle | 96/8552 | 137/18723 | 6.00e-09 | 1.23e-07 | 96 |
GO:00070934 | Esophagus | ESCC | mitotic cell cycle checkpoint | 90/8552 | 129/18723 | 2.49e-08 | 4.69e-07 | 90 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:004593013 | Esophagus | ESCC | negative regulation of mitotic cell cycle | 143/8552 | 235/18723 | 1.84e-06 | 2.15e-05 | 143 |
GO:0051402110 | Esophagus | ESCC | neuron apoptotic process | 148/8552 | 246/18723 | 3.08e-06 | 3.47e-05 | 148 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:190199113 | Esophagus | ESCC | negative regulation of mitotic cell cycle phase transition | 112/8552 | 179/18723 | 3.69e-06 | 4.03e-05 | 112 |
GO:00103891 | Esophagus | ESCC | regulation of G2/M transition of mitotic cell cycle | 64/8552 | 94/18723 | 9.21e-06 | 8.82e-05 | 64 |
GO:19027491 | Esophagus | ESCC | regulation of cell cycle G2/M phase transition | 68/8552 | 102/18723 | 1.48e-05 | 1.33e-04 | 68 |
GO:00447745 | Esophagus | ESCC | mitotic DNA integrity checkpoint | 56/8552 | 85/18723 | 1.34e-04 | 9.09e-04 | 56 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa0501014 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0501015 | Liver | Cirrhotic | Alzheimer disease | 180/2530 | 384/8465 | 5.52e-13 | 1.36e-11 | 8.36e-12 | 180 |
hsa0501022 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0501032 | Liver | HCC | Alzheimer disease | 254/4020 | 384/8465 | 3.75e-14 | 8.97e-13 | 4.99e-13 | 254 |
hsa0501028 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa05010112 | Oral cavity | OSCC | Alzheimer disease | 244/3704 | 384/8465 | 1.18e-15 | 3.60e-14 | 1.83e-14 | 244 |
hsa0501029 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
hsa0501037 | Oral cavity | LP | Alzheimer disease | 197/2418 | 384/8465 | 6.66e-22 | 3.69e-20 | 2.38e-20 | 197 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAE1 | SNV | Missense_Mutation | rs759084335 | c.1177N>G | p.Leu393Val | p.L393V | Q13564 | protein_coding | tolerated(0.05) | benign(0.226) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NAE1 | SNV | Missense_Mutation | c.1277N>A | p.Ile426Lys | p.I426K | Q13564 | protein_coding | deleterious(0.01) | benign(0.022) | TCGA-AR-A1AN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
NAE1 | deletion | Frame_Shift_Del | novel | c.960delA | p.Glu321ArgfsTer15 | p.E321Rfs*15 | Q13564 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
NAE1 | SNV | Missense_Mutation | novel | c.1297C>T | p.Arg433Trp | p.R433W | Q13564 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NAE1 | SNV | Missense_Mutation | novel | c.784N>T | p.Pro262Ser | p.P262S | Q13564 | protein_coding | tolerated(0.3) | benign(0) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
NAE1 | SNV | Missense_Mutation | c.1140N>T | p.Glu380Asp | p.E380D | Q13564 | protein_coding | tolerated(0.28) | benign(0) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
NAE1 | SNV | Missense_Mutation | rs762421870 | c.1460G>A | p.Arg487Gln | p.R487Q | Q13564 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAE1 | SNV | Missense_Mutation | c.445T>C | p.Ser149Pro | p.S149P | Q13564 | protein_coding | tolerated(0.22) | benign(0.005) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NAE1 | SNV | Missense_Mutation | novel | c.607N>T | p.Asp203Tyr | p.D203Y | Q13564 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
NAE1 | SNV | Missense_Mutation | novel | c.1093N>T | p.Ala365Ser | p.A365S | Q13564 | protein_coding | tolerated(0.66) | benign(0.005) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8883 | NAE1 | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1231160 | PEVONEDISTAT |
Page: 1 |