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Gene: MYO19 |
Gene summary for MYO19 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MYO19 | Gene ID | 80179 |
| Gene name | myosin XIX | |
| Gene Alias | MYOHD1 | |
| Cytomap | 17q12 | |
| Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | A0A024R0S9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 80179 | MYO19 | C30 | Human | Oral cavity | OSCC | 3.51e-42 | 1.87e+00 | 0.3055 |
| 80179 | MYO19 | C38 | Human | Oral cavity | OSCC | 7.42e-06 | 6.49e-01 | 0.172 |
| 80179 | MYO19 | C43 | Human | Oral cavity | OSCC | 2.07e-17 | 5.04e-01 | 0.1704 |
| 80179 | MYO19 | C46 | Human | Oral cavity | OSCC | 5.77e-19 | 5.65e-01 | 0.1673 |
| 80179 | MYO19 | C51 | Human | Oral cavity | OSCC | 6.91e-14 | 9.22e-01 | 0.2674 |
| 80179 | MYO19 | C57 | Human | Oral cavity | OSCC | 4.79e-09 | 3.52e-01 | 0.1679 |
| 80179 | MYO19 | C08 | Human | Oral cavity | OSCC | 4.74e-15 | 4.87e-01 | 0.1919 |
| 80179 | MYO19 | C09 | Human | Oral cavity | OSCC | 9.87e-04 | 2.02e-01 | 0.1431 |
| 80179 | MYO19 | LN22 | Human | Oral cavity | OSCC | 1.08e-05 | 7.96e-01 | 0.1733 |
| 80179 | MYO19 | LN46 | Human | Oral cavity | OSCC | 1.34e-19 | 7.00e-01 | 0.1666 |
| 80179 | MYO19 | LP15 | Human | Oral cavity | LP | 2.29e-02 | 5.74e-01 | 0.2174 |
| 80179 | MYO19 | SYSMH1 | Human | Oral cavity | OSCC | 2.35e-22 | 5.44e-01 | 0.1127 |
| 80179 | MYO19 | SYSMH2 | Human | Oral cavity | OSCC | 3.45e-15 | 4.76e-01 | 0.2326 |
| 80179 | MYO19 | SYSMH3 | Human | Oral cavity | OSCC | 2.51e-30 | 8.65e-01 | 0.2442 |
| 80179 | MYO19 | SYSMH5 | Human | Oral cavity | OSCC | 8.89e-13 | 4.36e-01 | 0.0647 |
| 80179 | MYO19 | P1_S1_AK | Human | Skin | AK | 1.06e-08 | 2.94e-01 | -0.3399 |
| 80179 | MYO19 | P2_S3_AK | Human | Skin | AK | 1.31e-05 | 2.44e-01 | -0.3287 |
| 80179 | MYO19 | P4_S8_cSCC | Human | Skin | cSCC | 1.07e-05 | 2.04e-01 | -0.3095 |
| 80179 | MYO19 | P5_S10_cSCC | Human | Skin | cSCC | 1.83e-05 | 1.80e-01 | -0.299 |
| 80179 | MYO19 | P1_cSCC | Human | Skin | cSCC | 8.41e-27 | 8.84e-01 | 0.0292 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
| GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
| GO:00108218 | Cervix | CC | regulation of mitochondrion organization | 34/2311 | 144/18723 | 1.27e-04 | 1.58e-03 | 34 |
| GO:00513021 | Cervix | CC | regulation of cell division | 39/2311 | 177/18723 | 2.05e-04 | 2.33e-03 | 39 |
| GO:00009107 | Cervix | CC | cytokinesis | 37/2311 | 173/18723 | 5.40e-04 | 5.23e-03 | 37 |
| GO:00300487 | Cervix | CC | actin filament-based movement | 29/2311 | 127/18723 | 6.91e-04 | 6.33e-03 | 29 |
| GO:00307057 | Cervix | CC | cytoskeleton-dependent intracellular transport | 40/2311 | 195/18723 | 7.92e-04 | 6.99e-03 | 40 |
| GO:0032465 | Cervix | CC | regulation of cytokinesis | 22/2311 | 92/18723 | 1.55e-03 | 1.20e-02 | 22 |
| GO:00516541 | Cervix | CC | establishment of mitochondrion localization | 10/2311 | 29/18723 | 1.74e-03 | 1.31e-02 | 10 |
| GO:00995157 | Cervix | CC | actin filament-based transport | 8/2311 | 21/18723 | 2.44e-03 | 1.71e-02 | 8 |
| GO:00300507 | Cervix | CC | vesicle transport along actin filament | 7/2311 | 19/18723 | 5.65e-03 | 3.25e-02 | 7 |
| GO:00516461 | Cervix | CC | mitochondrion localization | 13/2311 | 50/18723 | 6.42e-03 | 3.58e-02 | 13 |
| GO:00482851 | Cervix | CC | organelle fission | 78/2311 | 488/18723 | 9.70e-03 | 4.79e-02 | 78 |
| GO:005165616 | Esophagus | HGIN | establishment of organelle localization | 90/2587 | 390/18723 | 4.27e-07 | 1.94e-05 | 90 |
| GO:001082119 | Esophagus | HGIN | regulation of mitochondrion organization | 42/2587 | 144/18723 | 1.20e-06 | 4.68e-05 | 42 |
| GO:000091015 | Esophagus | HGIN | cytokinesis | 44/2587 | 173/18723 | 3.26e-05 | 8.32e-04 | 44 |
| GO:003070517 | Esophagus | HGIN | cytoskeleton-dependent intracellular transport | 45/2587 | 195/18723 | 3.07e-04 | 5.15e-03 | 45 |
| GO:005165010 | Esophagus | HGIN | establishment of vesicle localization | 35/2587 | 161/18723 | 3.89e-03 | 3.54e-02 | 35 |
| GO:00516542 | Esophagus | HGIN | establishment of mitochondrion localization | 10/2587 | 29/18723 | 4.07e-03 | 3.65e-02 | 10 |
| GO:005164810 | Esophagus | HGIN | vesicle localization | 37/2587 | 177/18723 | 6.03e-03 | 4.87e-02 | 37 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MYO19 | SNV | Missense_Mutation | rs532830674 | c.2585G>A | p.Arg862His | p.R862H | Q96H55 | protein_coding | tolerated(0.17) | benign(0.012) | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| MYO19 | SNV | Missense_Mutation | rs765344804 | c.2794N>T | p.Arg932Trp | p.R932W | Q96H55 | protein_coding | deleterious(0.03) | benign(0.332) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
| MYO19 | insertion | Frame_Shift_Ins | novel | c.2809_2810insTGGT | p.Cys937LeufsTer4 | p.C937Lfs*4 | Q96H55 | protein_coding | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MYO19 | insertion | Frame_Shift_Ins | novel | c.2807_2808insTTCCGCATTAAATGCAGTAACAGATACCAGTT | p.Cys937SerfsTer33 | p.C937Sfs*33 | Q96H55 | protein_coding | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| MYO19 | SNV | Missense_Mutation | novel | c.2006N>G | p.Tyr669Cys | p.Y669C | Q96H55 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MYO19 | SNV | Missense_Mutation | novel | c.1691N>G | p.Asp564Gly | p.D564G | Q96H55 | protein_coding | tolerated(0.25) | possibly_damaging(0.87) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MYO19 | SNV | Missense_Mutation | novel | c.1588N>A | p.Val530Met | p.V530M | Q96H55 | protein_coding | tolerated(0.14) | benign(0.022) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MYO19 | SNV | Missense_Mutation | rs369381777 | c.584N>A | p.Arg195His | p.R195H | Q96H55 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| MYO19 | SNV | Missense_Mutation | rs766865716 | c.670N>G | p.Arg224Gly | p.R224G | Q96H55 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| MYO19 | SNV | Missense_Mutation | rs776257543 | c.2270G>A | p.Arg757His | p.R757H | Q96H55 | protein_coding | deleterious(0) | probably_damaging(0.915) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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