Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MYDGF

Gene summary for MYDGF

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MYDGF

Gene ID

56005

Gene namemyeloid derived growth factor
Gene AliasC19orf10
Cytomap19p13.3
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

Q969H8


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
56005MYDGFP56T-EHumanEsophagusESCC9.32e-081.60e+000.1613
56005MYDGFP57T-EHumanEsophagusESCC1.19e-431.01e+000.0926
56005MYDGFP61T-EHumanEsophagusESCC2.31e-231.10e+000.099
56005MYDGFP62T-EHumanEsophagusESCC6.14e-731.91e+000.1302
56005MYDGFP65T-EHumanEsophagusESCC5.59e-218.32e-010.0978
56005MYDGFP74T-EHumanEsophagusESCC2.24e-381.62e+000.1479
56005MYDGFP75T-EHumanEsophagusESCC6.42e-811.90e+000.1125
56005MYDGFP76T-EHumanEsophagusESCC6.51e-661.66e+000.1207
56005MYDGFP79T-EHumanEsophagusESCC4.37e-461.12e+000.1154
56005MYDGFP80T-EHumanEsophagusESCC8.70e-532.28e+000.155
56005MYDGFP82T-EHumanEsophagusESCC2.03e-271.99e+000.1072
56005MYDGFP83T-EHumanEsophagusESCC4.59e-552.77e+000.1738
56005MYDGFP84T-EHumanEsophagusESCC6.95e-081.13e+000.0933
56005MYDGFP89T-EHumanEsophagusESCC1.01e-262.74e+000.1752
56005MYDGFP91T-EHumanEsophagusESCC1.85e-243.04e+000.1828
56005MYDGFP94T-EHumanEsophagusESCC8.47e-082.09e+000.0879
56005MYDGFP107T-EHumanEsophagusESCC1.12e-602.09e+000.171
56005MYDGFP126T-EHumanEsophagusESCC1.43e-162.07e+000.1125
56005MYDGFP127T-EHumanEsophagusESCC4.80e-267.09e-010.0826
56005MYDGFP128T-EHumanEsophagusESCC2.70e-602.59e+000.1241
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00506737CervixCCepithelial cell proliferation98/2311437/187232.01e-092.15e-0798
GO:00506787CervixCCregulation of epithelial cell proliferation83/2311381/187231.31e-076.42e-0683
GO:00506794CervixCCpositive regulation of epithelial cell proliferation47/2311207/187232.18e-053.90e-0447
GO:00434104CervixCCpositive regulation of MAPK cascade90/2311480/187232.92e-054.83e-0490
GO:00518964CervixCCregulation of protein kinase B signaling39/2311185/187235.25e-045.10e-0339
GO:00518973CervixCCpositive regulation of protein kinase B signaling28/2311120/187235.90e-045.59e-0328
GO:00434913CervixCCprotein kinase B signaling43/2311211/187235.95e-045.60e-0343
GO:19013423CervixCCregulation of vasculature development60/2311348/187234.48e-032.72e-0260
GO:00457653CervixCCregulation of angiogenesis59/2311342/187234.73e-032.83e-0259
GO:0014065CervixCCphosphatidylinositol 3-kinase signaling28/2311144/187239.50e-034.72e-0228
GO:004576611CervixN_HPVpositive regulation of angiogenesis18/534181/187234.51e-061.71e-0418
GO:190401811CervixN_HPVpositive regulation of vasculature development18/534181/187234.51e-061.71e-0418
GO:004576521CervixN_HPVregulation of angiogenesis25/534342/187231.80e-055.30e-0425
GO:190134221CervixN_HPVregulation of vasculature development25/534348/187232.41e-056.66e-0425
GO:005189711CervixN_HPVpositive regulation of protein kinase B signaling10/534120/187232.30e-032.13e-0210
GO:005189611CervixN_HPVregulation of protein kinase B signaling12/534185/187236.94e-034.59e-0212
GO:004349112CervixN_HPVprotein kinase B signaling13/534211/187237.72e-034.97e-0213
GO:0050673ColorectumADepithelial cell proliferation119/3918437/187238.75e-048.51e-03119
GO:0048017ColorectumADinositol lipid-mediated signaling53/3918182/187235.35e-033.52e-0253
GO:0048015ColorectumADphosphatidylinositol-mediated signaling52/3918178/187235.37e-033.54e-0252
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MYDGFSNVMissense_Mutationc.218N>Ap.Thr73Asnp.T73NQ969H8protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AO-A0JD-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
MYDGFSNVMissense_Mutationc.394N>Cp.Ser132Argp.S132RQ969H8protein_codingtolerated(0.09)possibly_damaging(0.744)TCGA-EW-A1OZ-01Breastbreast invasive carcinomaFemale<65I/IITargeted Molecular therapytrastuzumabSD
MYDGFdeletionFrame_Shift_Delc.394delNp.Ser132ValfsTer5p.S132Vfs*5Q969H8protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
MYDGFSNVMissense_Mutationc.353A>Tp.Glu118Valp.E118VQ969H8protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AA-3864-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
MYDGFSNVMissense_Mutationnovelc.397G>Tp.Asp133Tyrp.D133YQ969H8protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A5-A2K5-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MYDGFSNVMissense_Mutationc.264N>Tp.Gln88Hisp.Q88HQ969H8protein_codingtolerated(0.11)possibly_damaging(0.855)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MYDGFSNVMissense_Mutationrs200622596c.253N>Ap.Glu85Lysp.E85KQ969H8protein_codingtolerated(0.05)benign(0.015)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MYDGFSNVMissense_Mutationrs769735674c.358N>Ap.Ala120Thrp.A120TQ969H8protein_codingdeleterious(0.01)benign(0.314)TCGA-D1-A103-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
MYDGFSNVMissense_Mutationnovelc.268N>Cp.Phe90Leup.F90LQ969H8protein_codingtolerated(0.07)benign(0.048)TCGA-D1-A175-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapypaclitaxelSD
MYDGFSNVMissense_Mutationnovelc.182N>Gp.Tyr61Cysp.Y61CQ969H8protein_codingdeleterious(0)possibly_damaging(0.807)TCGA-EO-A22X-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnspecificCarboplatinComplete Response
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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