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Gene: MUM1 |
Gene summary for MUM1 |
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Gene information | Species | Human | Gene symbol | MUM1 | Gene ID | 84939 |
Gene name | PWWP domain containing 3A, DNA repair factor | |
Gene Alias | EXPAND1 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | J3KNX4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84939 | MUM1 | C09 | Human | Oral cavity | OSCC | 3.90e-07 | 3.76e-01 | 0.1431 |
84939 | MUM1 | LN46 | Human | Oral cavity | OSCC | 3.29e-04 | 3.90e-01 | 0.1666 |
84939 | MUM1 | LP15 | Human | Oral cavity | LP | 9.28e-05 | 7.57e-01 | 0.2174 |
84939 | MUM1 | LP17 | Human | Oral cavity | LP | 6.88e-05 | 5.49e-01 | 0.2349 |
84939 | MUM1 | EOLP-2 | Human | Oral cavity | EOLP | 1.66e-02 | -9.89e-02 | -0.0203 |
84939 | MUM1 | NEOLP-1 | Human | Oral cavity | NEOLP | 3.50e-02 | -9.89e-02 | -0.0194 |
84939 | MUM1 | NEOLP-3 | Human | Oral cavity | NEOLP | 3.50e-02 | -9.89e-02 | -0.0191 |
84939 | MUM1 | SYSMH1 | Human | Oral cavity | OSCC | 8.81e-17 | 4.34e-01 | 0.1127 |
84939 | MUM1 | SYSMH2 | Human | Oral cavity | OSCC | 1.12e-15 | 5.85e-01 | 0.2326 |
84939 | MUM1 | SYSMH3 | Human | Oral cavity | OSCC | 3.07e-21 | 6.51e-01 | 0.2442 |
84939 | MUM1 | SYSMH5 | Human | Oral cavity | OSCC | 1.63e-07 | 3.06e-01 | 0.0647 |
84939 | MUM1 | SYSMH6 | Human | Oral cavity | OSCC | 3.43e-07 | 3.34e-01 | 0.1275 |
84939 | MUM1 | P1_cSCC | Human | Skin | cSCC | 1.98e-12 | 4.43e-01 | 0.0292 |
84939 | MUM1 | P2_cSCC | Human | Skin | cSCC | 2.82e-10 | 3.59e-01 | -0.024 |
84939 | MUM1 | P4_cSCC | Human | Skin | cSCC | 2.89e-08 | 1.77e-01 | -0.00290000000000005 |
84939 | MUM1 | P10_cSCC | Human | Skin | cSCC | 3.41e-13 | 4.53e-01 | 0.1017 |
84939 | MUM1 | PTC01 | Human | Thyroid | PTC | 1.92e-19 | 3.79e-01 | 0.1899 |
84939 | MUM1 | PTC03 | Human | Thyroid | PTC | 2.09e-06 | 2.79e-01 | 0.1784 |
84939 | MUM1 | PTC04 | Human | Thyroid | PTC | 2.18e-22 | 3.94e-01 | 0.1927 |
84939 | MUM1 | PTC05 | Human | Thyroid | PTC | 7.27e-24 | 6.59e-01 | 0.2065 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUM1 | SNV | Missense_Mutation | novel | c.862N>A | p.Glu288Lys | p.E288K | protein_coding | tolerated(0.3) | benign(0.108) | TCGA-AC-A8OS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | novel | c.278N>A | p.Arg93His | p.R93H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | c.137T>C | p.Leu46Pro | p.L46P | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MUM1 | SNV | Missense_Mutation | rs147961437 | c.232G>A | p.Val78Ile | p.V78I | protein_coding | tolerated(0.17) | benign(0.105) | TCGA-AN-A0FW-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | c.1115N>G | p.Glu372Gly | p.E372G | protein_coding | tolerated(0.19) | benign(0) | TCGA-E9-A24A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MUM1 | SNV | Missense_Mutation | c.1378N>T | p.Leu460Phe | p.L460F | protein_coding | tolerated(0.41) | probably_damaging(0.976) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
MUM1 | insertion | In_Frame_Ins | novel | c.432_433insCAGAATTTGCCCCTAGAACCACTCCTATTC | p.Val144_Leu145insGlnAsnLeuProLeuGluProLeuLeuPhe | p.V144_L145insQNLPLEPLLF | protein_coding | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MUM1 | deletion | Frame_Shift_Del | novel | c.1102delN | p.Lys368SerfsTer45 | p.K368Sfs*45 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
MUM1 | SNV | Missense_Mutation | rs773907661 | c.308N>T | p.Ser103Leu | p.S103L | protein_coding | tolerated(0.07) | benign(0.001) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MUM1 | SNV | Missense_Mutation | c.707N>T | p.Ser236Leu | p.S236L | protein_coding | tolerated(0.16) | benign(0.14) | TCGA-C5-A1BK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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