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Gene: MPRIP |
Gene summary for MPRIP |
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Gene information | Species | Human | Gene symbol | MPRIP | Gene ID | 23164 |
Gene name | myosin phosphatase Rho interacting protein | |
Gene Alias | M-RIP | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q6WCQ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23164 | MPRIP | ATC09 | Human | Thyroid | ATC | 9.06e-10 | 2.54e-01 | 0.2871 |
23164 | MPRIP | ATC11 | Human | Thyroid | ATC | 6.54e-06 | 5.05e-01 | 0.3386 |
23164 | MPRIP | ATC12 | Human | Thyroid | ATC | 2.15e-07 | 1.08e-01 | 0.34 |
23164 | MPRIP | ATC13 | Human | Thyroid | ATC | 7.64e-33 | 6.22e-01 | 0.34 |
23164 | MPRIP | ATC1 | Human | Thyroid | ATC | 1.07e-06 | 3.45e-01 | 0.2878 |
23164 | MPRIP | ATC2 | Human | Thyroid | ATC | 4.40e-19 | 1.48e+00 | 0.34 |
23164 | MPRIP | ATC3 | Human | Thyroid | ATC | 9.20e-11 | 5.06e-01 | 0.338 |
23164 | MPRIP | ATC4 | Human | Thyroid | ATC | 1.04e-11 | 2.17e-01 | 0.34 |
23164 | MPRIP | ATC5 | Human | Thyroid | ATC | 1.95e-30 | 6.78e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
GO:000701518 | Prostate | BPH | actin filament organization | 147/3107 | 442/18723 | 3.36e-18 | 1.15e-15 | 147 |
GO:000701519 | Prostate | Tumor | actin filament organization | 142/3246 | 442/18723 | 1.40e-14 | 1.89e-12 | 142 |
GO:0007015112 | Thyroid | PTC | actin filament organization | 225/5968 | 442/18723 | 3.76e-17 | 3.44e-15 | 225 |
GO:0007015210 | Thyroid | ATC | actin filament organization | 227/6293 | 442/18723 | 5.96e-15 | 3.85e-13 | 227 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MPRIP | SNV | Missense_Mutation | c.1270G>A | p.Glu424Lys | p.E424K | Q6WCQ1 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
MPRIP | SNV | Missense_Mutation | novel | c.1298T>A | p.Ile433Asn | p.I433N | Q6WCQ1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
MPRIP | SNV | Missense_Mutation | c.3005G>C | p.Arg1002Thr | p.R1002T | Q6WCQ1 | protein_coding | tolerated_low_confidence(0.05) | possibly_damaging(0.79) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MPRIP | deletion | Frame_Shift_Del | novel | c.1206delN | p.Gln402HisfsTer14 | p.Q402Hfs*14 | Q6WCQ1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MPRIP | SNV | Missense_Mutation | novel | c.1554N>T | p.Glu518Asp | p.E518D | Q6WCQ1 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MPRIP | SNV | Missense_Mutation | novel | c.2713N>G | p.Leu905Val | p.L905V | Q6WCQ1 | protein_coding | tolerated(0.1) | possibly_damaging(0.74) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MPRIP | deletion | Frame_Shift_Del | c.1052delN | p.Pro353GlnfsTer30 | p.P353Qfs*30 | Q6WCQ1 | protein_coding | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |||
MPRIP | deletion | Frame_Shift_Del | c.1085delN | p.Leu364CysfsTer19 | p.L364Cfs*19 | Q6WCQ1 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
MPRIP | SNV | Missense_Mutation | rs777364536 | c.1019C>T | p.Ala340Val | p.A340V | Q6WCQ1 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MPRIP | SNV | Missense_Mutation | c.1640A>G | p.Glu547Gly | p.E547G | Q6WCQ1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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