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Gene: MORF4L1 |
Gene summary for MORF4L1 |
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Gene information | Species | Human | Gene symbol | MORF4L1 | Gene ID | 10933 |
Gene name | mortality factor 4 like 1 | |
Gene Alias | Eaf3 | |
Cytomap | 15q25.1 | |
Gene Type | protein-coding | GO ID | GO:0000724 | UniProtAcc | Q9UBU8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10933 | MORF4L1 | P49T-E | Human | Esophagus | ESCC | 6.08e-24 | 2.50e+00 | 0.1768 |
10933 | MORF4L1 | P52T-E | Human | Esophagus | ESCC | 6.53e-35 | 1.58e+00 | 0.1555 |
10933 | MORF4L1 | P54T-E | Human | Esophagus | ESCC | 9.92e-23 | 8.76e-01 | 0.0975 |
10933 | MORF4L1 | P56T-E | Human | Esophagus | ESCC | 1.46e-16 | 2.33e+00 | 0.1613 |
10933 | MORF4L1 | P57T-E | Human | Esophagus | ESCC | 9.41e-36 | 1.00e+00 | 0.0926 |
10933 | MORF4L1 | P61T-E | Human | Esophagus | ESCC | 4.54e-19 | 9.80e-01 | 0.099 |
10933 | MORF4L1 | P62T-E | Human | Esophagus | ESCC | 2.45e-58 | 1.24e+00 | 0.1302 |
10933 | MORF4L1 | P65T-E | Human | Esophagus | ESCC | 7.10e-30 | 9.73e-01 | 0.0978 |
10933 | MORF4L1 | P74T-E | Human | Esophagus | ESCC | 8.97e-39 | 1.52e+00 | 0.1479 |
10933 | MORF4L1 | P75T-E | Human | Esophagus | ESCC | 2.50e-63 | 1.80e+00 | 0.1125 |
10933 | MORF4L1 | P76T-E | Human | Esophagus | ESCC | 1.80e-58 | 1.78e+00 | 0.1207 |
10933 | MORF4L1 | P79T-E | Human | Esophagus | ESCC | 2.51e-47 | 1.35e+00 | 0.1154 |
10933 | MORF4L1 | P80T-E | Human | Esophagus | ESCC | 4.69e-44 | 1.70e+00 | 0.155 |
10933 | MORF4L1 | P82T-E | Human | Esophagus | ESCC | 1.40e-31 | 2.18e+00 | 0.1072 |
10933 | MORF4L1 | P83T-E | Human | Esophagus | ESCC | 6.45e-49 | 1.88e+00 | 0.1738 |
10933 | MORF4L1 | P84T-E | Human | Esophagus | ESCC | 1.22e-16 | 1.44e+00 | 0.0933 |
10933 | MORF4L1 | P89T-E | Human | Esophagus | ESCC | 1.20e-17 | 1.85e+00 | 0.1752 |
10933 | MORF4L1 | P91T-E | Human | Esophagus | ESCC | 2.88e-25 | 3.03e+00 | 0.1828 |
10933 | MORF4L1 | P104T-E | Human | Esophagus | ESCC | 1.64e-02 | 1.15e+00 | 0.0931 |
10933 | MORF4L1 | P107T-E | Human | Esophagus | ESCC | 4.99e-69 | 2.18e+00 | 0.171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:0006302 | Colorectum | MSS | double-strand break repair | 64/3467 | 251/18723 | 3.58e-03 | 2.65e-02 | 64 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:001839413 | Esophagus | ESCC | peptidyl-lysine acetylation | 123/8552 | 169/18723 | 6.58e-13 | 2.94e-11 | 123 |
GO:004354313 | Esophagus | ESCC | protein acylation | 165/8552 | 243/18723 | 1.69e-12 | 7.14e-11 | 165 |
GO:000647313 | Esophagus | ESCC | protein acetylation | 140/8552 | 201/18723 | 4.37e-12 | 1.69e-10 | 140 |
GO:001839313 | Esophagus | ESCC | internal peptidyl-lysine acetylation | 114/8552 | 158/18723 | 1.16e-11 | 4.24e-10 | 114 |
GO:000647513 | Esophagus | ESCC | internal protein amino acid acetylation | 115/8552 | 160/18723 | 1.43e-11 | 5.08e-10 | 115 |
GO:00165735 | Esophagus | ESCC | histone acetylation | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:004396712 | Esophagus | ESCC | histone H4 acetylation | 53/8552 | 67/18723 | 2.11e-08 | 4.03e-07 | 53 |
GO:00356015 | Esophagus | ESCC | protein deacylation | 79/8552 | 112/18723 | 8.30e-08 | 1.42e-06 | 79 |
GO:00987325 | Esophagus | ESCC | macromolecule deacylation | 80/8552 | 116/18723 | 3.19e-07 | 4.50e-06 | 80 |
GO:00165754 | Esophagus | ESCC | histone deacetylation | 60/8552 | 82/18723 | 3.85e-07 | 5.32e-06 | 60 |
GO:00064765 | Esophagus | ESCC | protein deacetylation | 70/8552 | 101/18723 | 1.29e-06 | 1.58e-05 | 70 |
GO:00063024 | Esophagus | ESCC | double-strand break repair | 152/8552 | 251/18723 | 1.33e-06 | 1.62e-05 | 152 |
GO:00439682 | Esophagus | ESCC | histone H2A acetylation | 15/8552 | 17/18723 | 3.48e-04 | 2.03e-03 | 15 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:00007241 | Esophagus | ESCC | double-strand break repair via homologous recombination | 79/8552 | 138/18723 | 4.05e-03 | 1.62e-02 | 79 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MORF4L1 | SNV | Missense_Mutation | c.550G>A | p.Glu184Lys | p.E184K | Q9UBU8 | protein_coding | deleterious(0.01) | possibly_damaging(0.869) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MORF4L1 | SNV | Missense_Mutation | c.413C>G | p.Ser138Cys | p.S138C | Q9UBU8 | protein_coding | deleterious(0.01) | benign(0.289) | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
MORF4L1 | SNV | Missense_Mutation | c.353N>G | p.Ala118Gly | p.A118G | Q9UBU8 | protein_coding | deleterious(0) | possibly_damaging(0.802) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
MORF4L1 | SNV | Missense_Mutation | c.923N>A | p.Arg308Gln | p.R308Q | Q9UBU8 | protein_coding | tolerated(0.06) | benign(0.039) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MORF4L1 | deletion | Frame_Shift_Del | novel | c.1003_1004delAA | p.Lys335ValfsTer16 | p.K335Vfs*16 | Q9UBU8 | protein_coding | TCGA-HM-A3JJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | ||
MORF4L1 | SNV | Missense_Mutation | c.614C>T | p.Pro205Leu | p.P205L | Q9UBU8 | protein_coding | tolerated(0.1) | benign(0.221) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MORF4L1 | SNV | Missense_Mutation | c.453G>T | p.Lys151Asn | p.K151N | Q9UBU8 | protein_coding | deleterious(0.03) | benign(0.04) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MORF4L1 | SNV | Missense_Mutation | novel | c.643N>G | p.Thr215Ala | p.T215A | Q9UBU8 | protein_coding | deleterious(0.01) | benign(0.323) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MORF4L1 | SNV | Missense_Mutation | novel | c.697N>A | p.Leu233Ile | p.L233I | Q9UBU8 | protein_coding | tolerated(0.08) | possibly_damaging(0.712) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MORF4L1 | SNV | Missense_Mutation | novel | c.761N>C | p.Asn254Thr | p.N254T | Q9UBU8 | protein_coding | tolerated(0.6) | benign(0.042) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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