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Gene: MIS18BP1 |
Gene summary for MIS18BP1 |
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Gene information | Species | Human | Gene symbol | MIS18BP1 | Gene ID | 55320 |
Gene name | MIS18 binding protein 1 | |
Gene Alias | C14orf106 | |
Cytomap | 14q21.2 | |
Gene Type | protein-coding | GO ID | GO:0007049 | UniProtAcc | Q6P0N0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55320 | MIS18BP1 | P2_cSCC | Human | Skin | cSCC | 7.44e-11 | 3.83e-01 | -0.024 |
55320 | MIS18BP1 | P4_cSCC | Human | Skin | cSCC | 3.58e-19 | 4.50e-01 | -0.00290000000000005 |
55320 | MIS18BP1 | P10_cSCC | Human | Skin | cSCC | 7.64e-10 | 4.25e-01 | 0.1017 |
55320 | MIS18BP1 | cSCC_p8 | Human | Skin | cSCC | 1.19e-02 | 6.88e-02 | -0.1971 |
55320 | MIS18BP1 | male-WTA | Human | Thyroid | PTC | 3.73e-07 | 9.37e-02 | 0.1037 |
55320 | MIS18BP1 | PTC01 | Human | Thyroid | PTC | 1.33e-05 | 1.32e-01 | 0.1899 |
55320 | MIS18BP1 | PTC03 | Human | Thyroid | PTC | 5.58e-12 | 4.84e-01 | 0.1784 |
55320 | MIS18BP1 | PTC04 | Human | Thyroid | PTC | 1.41e-07 | 1.57e-01 | 0.1927 |
55320 | MIS18BP1 | PTC05 | Human | Thyroid | PTC | 3.33e-28 | 8.64e-01 | 0.2065 |
55320 | MIS18BP1 | PTC06 | Human | Thyroid | PTC | 1.18e-21 | 6.13e-01 | 0.2057 |
55320 | MIS18BP1 | PTC07 | Human | Thyroid | PTC | 2.94e-21 | 4.09e-01 | 0.2044 |
55320 | MIS18BP1 | ATC11 | Human | Thyroid | ATC | 2.81e-14 | 7.46e-01 | 0.3386 |
55320 | MIS18BP1 | ATC12 | Human | Thyroid | ATC | 8.24e-38 | 8.21e-01 | 0.34 |
55320 | MIS18BP1 | ATC13 | Human | Thyroid | ATC | 2.10e-51 | 9.20e-01 | 0.34 |
55320 | MIS18BP1 | ATC2 | Human | Thyroid | ATC | 1.21e-23 | 1.56e+00 | 0.34 |
55320 | MIS18BP1 | ATC3 | Human | Thyroid | ATC | 5.25e-12 | 6.01e-01 | 0.338 |
55320 | MIS18BP1 | ATC4 | Human | Thyroid | ATC | 2.12e-42 | 9.86e-01 | 0.34 |
55320 | MIS18BP1 | ATC5 | Human | Thyroid | ATC | 3.46e-57 | 1.02e+00 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIS18BP1 | SNV | Missense_Mutation | c.2194N>C | p.Glu732Gln | p.E732Q | Q6P0N0 | protein_coding | deleterious(0.03) | benign(0.024) | TCGA-AC-A5XS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | femara | SD | |
MIS18BP1 | SNV | Missense_Mutation | novel | c.609N>T | p.Lys203Asn | p.K203N | Q6P0N0 | protein_coding | tolerated(0.07) | benign(0.031) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MIS18BP1 | SNV | Missense_Mutation | c.862N>G | p.Leu288Val | p.L288V | Q6P0N0 | protein_coding | tolerated(0.5) | benign(0.024) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MIS18BP1 | SNV | Missense_Mutation | novel | c.917G>A | p.Ser306Asn | p.S306N | Q6P0N0 | protein_coding | tolerated(0.43) | benign(0.021) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
MIS18BP1 | SNV | Missense_Mutation | novel | c.1754T>G | p.Ile585Ser | p.I585S | Q6P0N0 | protein_coding | tolerated(0.29) | benign(0.017) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MIS18BP1 | SNV | Missense_Mutation | c.2702G>T | p.Gly901Val | p.G901V | Q6P0N0 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-BH-A0DQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
MIS18BP1 | SNV | Missense_Mutation | novel | c.3161G>T | p.Cys1054Phe | p.C1054F | Q6P0N0 | protein_coding | tolerated(0.18) | benign(0.367) | TCGA-BH-A0W7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MIS18BP1 | SNV | Missense_Mutation | c.2581N>C | p.Asp861His | p.D861H | Q6P0N0 | protein_coding | tolerated(0.06) | benign(0.201) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MIS18BP1 | SNV | Missense_Mutation | c.2579C>G | p.Ser860Cys | p.S860C | Q6P0N0 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
MIS18BP1 | SNV | Missense_Mutation | c.29N>C | p.Arg10Thr | p.R10T | Q6P0N0 | protein_coding | tolerated(0.11) | benign(0.043) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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