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Gene: MFSD14C |
Gene summary for MFSD14C |
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Gene information | Species | Human | Gene symbol | MFSD14C | Gene ID | 84278 |
Gene name | major facilitator superfamily domain containing 14C | |
Gene Alias | HIATL2 | |
Cytomap | 9q22.33 | |
Gene Type | pseudo | GO ID | GO:0006810 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84278 | MFSD14C | P47T-E | Human | Esophagus | ESCC | 8.23e-12 | 1.93e-01 | 0.1067 |
84278 | MFSD14C | P48T-E | Human | Esophagus | ESCC | 6.13e-10 | 2.43e-01 | 0.0959 |
84278 | MFSD14C | P49T-E | Human | Esophagus | ESCC | 1.01e-10 | 7.09e-01 | 0.1768 |
84278 | MFSD14C | P52T-E | Human | Esophagus | ESCC | 1.01e-30 | 5.43e-01 | 0.1555 |
84278 | MFSD14C | P54T-E | Human | Esophagus | ESCC | 1.94e-06 | 1.38e-01 | 0.0975 |
84278 | MFSD14C | P56T-E | Human | Esophagus | ESCC | 9.31e-06 | 6.59e-01 | 0.1613 |
84278 | MFSD14C | P57T-E | Human | Esophagus | ESCC | 2.97e-10 | 2.20e-01 | 0.0926 |
84278 | MFSD14C | P61T-E | Human | Esophagus | ESCC | 2.20e-13 | 2.99e-01 | 0.099 |
84278 | MFSD14C | P62T-E | Human | Esophagus | ESCC | 3.80e-11 | 2.51e-01 | 0.1302 |
84278 | MFSD14C | P65T-E | Human | Esophagus | ESCC | 6.54e-13 | 3.09e-01 | 0.0978 |
84278 | MFSD14C | P74T-E | Human | Esophagus | ESCC | 1.99e-12 | 3.88e-01 | 0.1479 |
84278 | MFSD14C | P75T-E | Human | Esophagus | ESCC | 2.12e-23 | 4.17e-01 | 0.1125 |
84278 | MFSD14C | P76T-E | Human | Esophagus | ESCC | 7.44e-07 | 1.40e-01 | 0.1207 |
84278 | MFSD14C | P79T-E | Human | Esophagus | ESCC | 3.35e-08 | 1.70e-01 | 0.1154 |
84278 | MFSD14C | P80T-E | Human | Esophagus | ESCC | 2.19e-14 | 4.33e-01 | 0.155 |
84278 | MFSD14C | P82T-E | Human | Esophagus | ESCC | 1.82e-02 | 1.75e-01 | 0.1072 |
84278 | MFSD14C | P83T-E | Human | Esophagus | ESCC | 1.32e-04 | 1.73e-01 | 0.1738 |
84278 | MFSD14C | P107T-E | Human | Esophagus | ESCC | 1.56e-06 | 2.16e-01 | 0.171 |
84278 | MFSD14C | P126T-E | Human | Esophagus | ESCC | 3.09e-02 | 4.12e-01 | 0.1125 |
84278 | MFSD14C | P127T-E | Human | Esophagus | ESCC | 6.47e-13 | 2.68e-01 | 0.0826 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD14C | SNV | Missense_Mutation | c.226N>G | p.Gln76Glu | p.Q76E | protein_coding | tolerated(0.5) | benign(0.011) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MFSD14C | SNV | Missense_Mutation | novel | c.133G>T | p.Val45Leu | p.V45L | protein_coding | tolerated(0.07) | possibly_damaging(0.517) | TCGA-D8-A1X8-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adrimicin+cyclophosphamide | SD | |
MFSD14C | SNV | Missense_Mutation | c.269G>A | p.Gly90Asp | p.G90D | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MFSD14C | SNV | Missense_Mutation | novel | c.216A>C | p.Glu72Asp | p.E72D | protein_coding | tolerated(0.22) | benign(0.099) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | novel | c.290N>T | p.Ala97Val | p.A97V | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | c.208N>A | p.Leu70Ile | p.L70I | protein_coding | deleterious(0.03) | possibly_damaging(0.883) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | ||
MFSD14C | SNV | Missense_Mutation | novel | c.367C>T | p.Pro123Ser | p.P123S | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-05-4420-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | novel | c.321G>T | p.Trp107Cys | p.W107C | protein_coding | deleterious(0.02) | benign(0.16) | TCGA-55-A4DG-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MFSD14C | SNV | Missense_Mutation | novel | c.289N>A | p.Ala97Thr | p.A97T | protein_coding | tolerated(0.09) | probably_damaging(0.923) | TCGA-NK-A5CR-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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