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Gene: MFSD14B |
Gene summary for MFSD14B |
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Gene information | Species | Human | Gene symbol | MFSD14B | Gene ID | 84641 |
Gene name | major facilitator superfamily domain containing 14B | |
Gene Alias | HIATL1 | |
Cytomap | 9q22.32 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5SR56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84641 | MFSD14B | P65T-E | Human | Esophagus | ESCC | 1.26e-09 | 7.70e-02 | 0.0978 |
84641 | MFSD14B | P74T-E | Human | Esophagus | ESCC | 1.01e-12 | 1.81e-01 | 0.1479 |
84641 | MFSD14B | P75T-E | Human | Esophagus | ESCC | 2.57e-16 | 1.94e-01 | 0.1125 |
84641 | MFSD14B | P76T-E | Human | Esophagus | ESCC | 1.98e-07 | -7.38e-02 | 0.1207 |
84641 | MFSD14B | P79T-E | Human | Esophagus | ESCC | 3.20e-04 | -3.70e-02 | 0.1154 |
84641 | MFSD14B | P80T-E | Human | Esophagus | ESCC | 5.78e-04 | 9.94e-02 | 0.155 |
84641 | MFSD14B | P82T-E | Human | Esophagus | ESCC | 3.92e-05 | 2.80e-01 | 0.1072 |
84641 | MFSD14B | P83T-E | Human | Esophagus | ESCC | 1.35e-08 | 1.66e-01 | 0.1738 |
84641 | MFSD14B | P89T-E | Human | Esophagus | ESCC | 6.06e-07 | 2.74e-01 | 0.1752 |
84641 | MFSD14B | P107T-E | Human | Esophagus | ESCC | 9.99e-11 | 2.18e-01 | 0.171 |
84641 | MFSD14B | P127T-E | Human | Esophagus | ESCC | 6.80e-08 | 8.72e-02 | 0.0826 |
84641 | MFSD14B | P128T-E | Human | Esophagus | ESCC | 1.15e-10 | 3.09e-01 | 0.1241 |
84641 | MFSD14B | P130T-E | Human | Esophagus | ESCC | 1.02e-23 | 4.88e-01 | 0.1676 |
84641 | MFSD14B | C04 | Human | Oral cavity | OSCC | 5.51e-15 | 8.98e-01 | 0.2633 |
84641 | MFSD14B | C21 | Human | Oral cavity | OSCC | 1.42e-15 | 6.46e-01 | 0.2678 |
84641 | MFSD14B | C30 | Human | Oral cavity | OSCC | 1.94e-41 | 1.81e+00 | 0.3055 |
84641 | MFSD14B | C38 | Human | Oral cavity | OSCC | 1.32e-03 | 6.64e-01 | 0.172 |
84641 | MFSD14B | C43 | Human | Oral cavity | OSCC | 4.72e-06 | 2.97e-01 | 0.1704 |
84641 | MFSD14B | C51 | Human | Oral cavity | OSCC | 1.35e-09 | 7.59e-01 | 0.2674 |
84641 | MFSD14B | C57 | Human | Oral cavity | OSCC | 1.78e-03 | 3.77e-01 | 0.1679 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD14B | insertion | Nonsense_Mutation | novel | c.782_783insACCTGAGAAGAGTGTAGGAATGTTCCCATAACTGTTTGCTTGTC | p.Phe262ProfsTer10 | p.F262Pfs*10 | Q5SR56 | protein_coding | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD | ||
MFSD14B | insertion | Frame_Shift_Ins | novel | c.828dupT | p.Leu277SerfsTer13 | p.L277Sfs*13 | Q5SR56 | protein_coding | TCGA-BH-A1F8-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
MFSD14B | SNV | Missense_Mutation | rs770993570 | c.1079N>T | p.Pro360Leu | p.P360L | Q5SR56 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MFSD14B | SNV | Missense_Mutation | c.1058N>T | p.Ala353Val | p.A353V | Q5SR56 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MFSD14B | SNV | Missense_Mutation | c.230N>G | p.His77Arg | p.H77R | Q5SR56 | protein_coding | tolerated(0.09) | probably_damaging(0.969) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MFSD14B | SNV | Missense_Mutation | novel | c.527N>T | p.Ala176Val | p.A176V | Q5SR56 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MFSD14B | SNV | Missense_Mutation | rs767889393 | c.173C>T | p.Ala58Val | p.A58V | Q5SR56 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MFSD14B | SNV | Missense_Mutation | rs200753636 | c.1423C>T | p.Arg475Trp | p.R475W | Q5SR56 | protein_coding | tolerated(0.07) | possibly_damaging(0.462) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MFSD14B | SNV | Missense_Mutation | rs199783937 | c.1399G>A | p.Gly467Ser | p.G467S | Q5SR56 | protein_coding | tolerated(0.44) | benign(0.009) | TCGA-AG-3882-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MFSD14B | SNV | Missense_Mutation | novel | c.674N>G | p.Met225Arg | p.M225R | Q5SR56 | protein_coding | tolerated(0.15) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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