|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: LINC01133 |
Gene summary for LINC01133 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LINC01133 | Gene ID | 100505633 |
| Gene name | long intergenic non-protein coding RNA 1133 | |
| Gene Alias | LINC01133 | |
| Cytomap | 1q23.2 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100505633 | LINC01133 | Pat03-B | Human | Stomach | GC | 1.49e-21 | 1.73e-01 | 0.3693 |
| 100505633 | LINC01133 | Pat04-B | Human | Stomach | GC | 2.73e-26 | 2.88e-01 | -0.1483 |
| 100505633 | LINC01133 | Pat05-B | Human | Stomach | GC | 3.24e-07 | 1.77e-01 | -0.0353 |
| 100505633 | LINC01133 | Pat06-B | Human | Stomach | GC | 1.31e-27 | 2.58e-02 | -0.1961 |
| 100505633 | LINC01133 | Pat10-B | Human | Stomach | GC | 8.53e-03 | 3.00e-01 | 0.084 |
| 100505633 | LINC01133 | Pat11-B | Human | Stomach | GC | 6.13e-14 | 2.09e-01 | -0.182 |
| 100505633 | LINC01133 | Pat12-B | Human | Stomach | GC | 2.11e-11 | 1.82e-01 | 0.0325 |
| 100505633 | LINC01133 | Pat15-B | Human | Stomach | GC | 2.04e-07 | 3.48e-02 | -0.0778 |
| 100505633 | LINC01133 | Pat17-B | Human | Stomach | GC | 4.34e-02 | 1.79e-01 | 0.3109 |
| 100505633 | LINC01133 | Pat18-B | Human | Stomach | GC | 1.95e-06 | 1.67e-01 | -0.0432 |
| 100505633 | LINC01133 | Pat19-B | Human | Stomach | GC | 3.95e-09 | 1.85e-01 | 0.0826 |
| 100505633 | LINC01133 | Pat22-B | Human | Stomach | GC | 1.53e-32 | 3.52e-01 | -0.1042 |
| 100505633 | LINC01133 | Pat24-B | Human | Stomach | GC | 1.91e-13 | 2.00e-01 | -0.1184 |
| 100505633 | LINC01133 | Pat25-A | Human | Stomach | CAG with IM | 2.56e-32 | 5.70e-02 | -0.1648 |
| 100505633 | LINC01133 | Pat26-A | Human | Stomach | CSG | 2.50e-41 | 2.22e-01 | -0.2402 |
| 100505633 | LINC01133 | Pat28-A | Human | Stomach | CSG | 6.22e-18 | 2.26e-01 | -0.2594 |
| 100505633 | LINC01133 | Pat29-A | Human | Stomach | CAG with IM | 2.86e-11 | 2.02e-01 | -0.2769 |
| 100505633 | LINC01133 | SIM_2 | Human | Stomach | SIM | 2.95e-04 | 2.74e-01 | 0.3139 |
| 100505633 | LINC01133 | EGC | Human | Stomach | GC | 7.56e-03 | -4.09e-01 | 0.1683 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |