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Gene: LAD1 |
Gene summary for LAD1 |
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Gene information | Species | Human | Gene symbol | LAD1 | Gene ID | 3898 |
Gene name | ladinin 1 | |
Gene Alias | LadA | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | O00515 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3898 | LAD1 | P47T-E | Human | Esophagus | ESCC | 1.87e-32 | 7.78e-01 | 0.1067 |
3898 | LAD1 | P48T-E | Human | Esophagus | ESCC | 1.32e-29 | 6.25e-01 | 0.0959 |
3898 | LAD1 | P49T-E | Human | Esophagus | ESCC | 3.35e-21 | 3.04e+00 | 0.1768 |
3898 | LAD1 | P52T-E | Human | Esophagus | ESCC | 3.59e-84 | 1.80e+00 | 0.1555 |
3898 | LAD1 | P54T-E | Human | Esophagus | ESCC | 1.19e-42 | 1.01e+00 | 0.0975 |
3898 | LAD1 | P57T-E | Human | Esophagus | ESCC | 2.11e-09 | 4.07e-01 | 0.0926 |
3898 | LAD1 | P61T-E | Human | Esophagus | ESCC | 3.66e-11 | 1.71e-01 | 0.099 |
3898 | LAD1 | P62T-E | Human | Esophagus | ESCC | 3.01e-86 | 1.81e+00 | 0.1302 |
3898 | LAD1 | P65T-E | Human | Esophagus | ESCC | 9.99e-29 | 7.82e-01 | 0.0978 |
3898 | LAD1 | P74T-E | Human | Esophagus | ESCC | 9.00e-52 | 1.96e+00 | 0.1479 |
3898 | LAD1 | P75T-E | Human | Esophagus | ESCC | 4.32e-44 | 9.97e-01 | 0.1125 |
3898 | LAD1 | P76T-E | Human | Esophagus | ESCC | 3.23e-25 | 6.30e-01 | 0.1207 |
3898 | LAD1 | P79T-E | Human | Esophagus | ESCC | 7.68e-11 | 3.05e-01 | 0.1154 |
3898 | LAD1 | P80T-E | Human | Esophagus | ESCC | 2.00e-45 | 1.57e+00 | 0.155 |
3898 | LAD1 | P82T-E | Human | Esophagus | ESCC | 4.13e-21 | 1.53e+00 | 0.1072 |
3898 | LAD1 | P83T-E | Human | Esophagus | ESCC | 1.89e-77 | 2.79e+00 | 0.1738 |
3898 | LAD1 | P84T-E | Human | Esophagus | ESCC | 1.53e-09 | 1.08e+00 | 0.0933 |
3898 | LAD1 | P89T-E | Human | Esophagus | ESCC | 4.04e-30 | 2.33e+00 | 0.1752 |
3898 | LAD1 | P91T-E | Human | Esophagus | ESCC | 6.83e-21 | 3.15e+00 | 0.1828 |
3898 | LAD1 | P94T-E | Human | Esophagus | ESCC | 7.37e-04 | 9.54e-01 | 0.0879 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:000916516 | Esophagus | ESCC | nucleotide biosynthetic process | 150/8552 | 254/18723 | 1.12e-05 | 1.06e-04 | 150 |
GO:190129316 | Esophagus | ESCC | nucleoside phosphate biosynthetic process | 151/8552 | 256/18723 | 1.15e-05 | 1.08e-04 | 151 |
GO:00067671 | Esophagus | ESCC | water-soluble vitamin metabolic process | 41/8552 | 59/18723 | 1.84e-04 | 1.17e-03 | 41 |
GO:00067661 | Esophagus | ESCC | vitamin metabolic process | 67/8552 | 106/18723 | 2.03e-04 | 1.28e-03 | 67 |
GO:000911722 | Liver | HCC | nucleotide metabolic process | 300/7958 | 489/18723 | 1.61e-17 | 1.71e-15 | 300 |
GO:000675322 | Liver | HCC | nucleoside phosphate metabolic process | 304/7958 | 497/18723 | 1.78e-17 | 1.85e-15 | 304 |
GO:000916512 | Liver | HCC | nucleotide biosynthetic process | 150/7958 | 254/18723 | 6.79e-08 | 1.40e-06 | 150 |
GO:190129312 | Liver | HCC | nucleoside phosphate biosynthetic process | 151/7958 | 256/18723 | 6.84e-08 | 1.41e-06 | 151 |
GO:0006767 | Liver | HCC | water-soluble vitamin metabolic process | 39/7958 | 59/18723 | 2.14e-04 | 1.63e-03 | 39 |
GO:0006766 | Liver | HCC | vitamin metabolic process | 57/7958 | 106/18723 | 1.25e-02 | 4.53e-02 | 57 |
GO:000675318 | Oral cavity | OSCC | nucleoside phosphate metabolic process | 247/7305 | 497/18723 | 6.28e-07 | 8.96e-06 | 247 |
GO:000911719 | Oral cavity | OSCC | nucleotide metabolic process | 243/7305 | 489/18723 | 7.80e-07 | 1.09e-05 | 243 |
GO:19012938 | Oral cavity | OSCC | nucleoside phosphate biosynthetic process | 125/7305 | 256/18723 | 8.32e-04 | 4.41e-03 | 125 |
GO:00091658 | Oral cavity | OSCC | nucleotide biosynthetic process | 124/7305 | 254/18723 | 8.79e-04 | 4.63e-03 | 124 |
GO:000675319 | Oral cavity | LP | nucleoside phosphate metabolic process | 161/4623 | 497/18723 | 5.31e-05 | 7.39e-04 | 161 |
GO:0009117110 | Oral cavity | LP | nucleotide metabolic process | 158/4623 | 489/18723 | 7.17e-05 | 9.49e-04 | 158 |
GO:190129315 | Oral cavity | LP | nucleoside phosphate biosynthetic process | 84/4623 | 256/18723 | 1.98e-03 | 1.47e-02 | 84 |
GO:000916515 | Oral cavity | LP | nucleotide biosynthetic process | 83/4623 | 254/18723 | 2.38e-03 | 1.71e-02 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAD1 | SNV | Missense_Mutation | rs762400082 | c.1270N>T | p.Arg424Trp | p.R424W | O00515 | protein_coding | deleterious(0) | possibly_damaging(0.627) | TCGA-E2-A1LE-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | herceptin | PD |
LAD1 | SNV | Missense_Mutation | novel | c.763N>A | p.Leu255Met | p.L255M | O00515 | protein_coding | tolerated(0.08) | benign(0.203) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LAD1 | SNV | Missense_Mutation | novel | c.53N>A | p.Arg18Lys | p.R18K | O00515 | protein_coding | tolerated(0.84) | benign(0.201) | TCGA-AA-3872-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
LAD1 | SNV | Missense_Mutation | rs764119320 | c.1501N>A | p.Glu501Lys | p.E501K | O00515 | protein_coding | tolerated(0.82) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
LAD1 | SNV | Missense_Mutation | novel | c.547N>G | p.Ser183Ala | p.S183A | O00515 | protein_coding | tolerated(0.3) | benign(0.005) | TCGA-AA-A029-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LAD1 | SNV | Missense_Mutation | rs754757676 | c.451N>T | p.Arg151Trp | p.R151W | O00515 | protein_coding | deleterious(0.02) | benign(0.011) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
LAD1 | SNV | Missense_Mutation | rs138881525 | c.127G>A | p.Asp43Asn | p.D43N | O00515 | protein_coding | tolerated(0.06) | possibly_damaging(0.883) | TCGA-AG-3591-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unspecific | Complete Response | |
LAD1 | SNV | Missense_Mutation | novel | c.671G>T | p.Arg224Ile | p.R224I | O00515 | protein_coding | tolerated(0.09) | benign(0.124) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LAD1 | SNV | Missense_Mutation | rs779029242 | c.193N>A | p.Val65Met | p.V65M | O00515 | protein_coding | tolerated(0.1) | possibly_damaging(0.783) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LAD1 | deletion | Frame_Shift_Del | c.976delN | p.Ala326LeufsTer18 | p.A326Lfs*18 | O00515 | protein_coding | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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