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Gene: KDM7A |
Gene summary for KDM7A |
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Gene information | Species | Human | Gene symbol | KDM7A | Gene ID | 80853 |
Gene name | lysine demethylase 7A | |
Gene Alias | JHDM1D | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6ZMT4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80853 | KDM7A | P82T-E | Human | Esophagus | ESCC | 3.16e-03 | 1.80e-01 | 0.1072 |
80853 | KDM7A | P83T-E | Human | Esophagus | ESCC | 9.39e-04 | 3.28e-01 | 0.1738 |
80853 | KDM7A | P84T-E | Human | Esophagus | ESCC | 2.14e-04 | 5.17e-01 | 0.0933 |
80853 | KDM7A | P91T-E | Human | Esophagus | ESCC | 4.98e-02 | 5.92e-01 | 0.1828 |
80853 | KDM7A | P104T-E | Human | Esophagus | ESCC | 2.04e-02 | 7.08e-02 | 0.0931 |
80853 | KDM7A | P107T-E | Human | Esophagus | ESCC | 4.32e-06 | 2.80e-01 | 0.171 |
80853 | KDM7A | P126T-E | Human | Esophagus | ESCC | 1.01e-02 | 7.27e-01 | 0.1125 |
80853 | KDM7A | P127T-E | Human | Esophagus | ESCC | 3.45e-14 | 1.88e-01 | 0.0826 |
80853 | KDM7A | P128T-E | Human | Esophagus | ESCC | 4.20e-16 | 3.95e-01 | 0.1241 |
80853 | KDM7A | P130T-E | Human | Esophagus | ESCC | 1.92e-10 | 1.18e-01 | 0.1676 |
80853 | KDM7A | NAFLD1 | Human | Liver | NAFLD | 3.13e-04 | 5.99e-01 | -0.04 |
80853 | KDM7A | S43 | Human | Liver | Cirrhotic | 2.69e-03 | -1.41e-01 | -0.0187 |
80853 | KDM7A | HCC1_Meng | Human | Liver | HCC | 1.86e-26 | -1.30e-01 | 0.0246 |
80853 | KDM7A | HCC2_Meng | Human | Liver | HCC | 3.13e-18 | -2.60e-02 | 0.0107 |
80853 | KDM7A | HCC2 | Human | Liver | HCC | 2.00e-05 | 2.63e+00 | 0.5341 |
80853 | KDM7A | Pt13.a | Human | Liver | HCC | 3.22e-02 | -1.37e-01 | 0.021 |
80853 | KDM7A | S014 | Human | Liver | HCC | 6.61e-03 | 3.40e-01 | 0.2254 |
80853 | KDM7A | S015 | Human | Liver | HCC | 3.27e-08 | 5.82e-01 | 0.2375 |
80853 | KDM7A | S016 | Human | Liver | HCC | 5.80e-10 | 4.81e-01 | 0.2243 |
80853 | KDM7A | RNA-P17T-P17T-2 | Human | Lung | IAC | 6.21e-10 | 1.18e+00 | 0.3371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030901 | Colorectum | AD | midbrain development | 32/3918 | 90/18723 | 9.45e-04 | 8.95e-03 | 32 |
GO:00309011 | Colorectum | SER | midbrain development | 29/2897 | 90/18723 | 5.50e-05 | 1.30e-03 | 29 |
GO:00309012 | Colorectum | MSS | midbrain development | 31/3467 | 90/18723 | 2.36e-04 | 3.24e-03 | 31 |
GO:0016570 | Colorectum | MSS | histone modification | 113/3467 | 463/18723 | 8.37e-04 | 8.68e-03 | 113 |
GO:00165701 | Colorectum | FAP | histone modification | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
GO:00309014 | Colorectum | FAP | midbrain development | 24/2622 | 90/18723 | 1.12e-03 | 1.08e-02 | 24 |
GO:00165702 | Colorectum | CRC | histone modification | 75/2078 | 463/18723 | 4.95e-04 | 7.06e-03 | 75 |
GO:00309015 | Colorectum | CRC | midbrain development | 21/2078 | 90/18723 | 7.06e-04 | 9.17e-03 | 21 |
GO:001657015 | Esophagus | ESCC | histone modification | 323/8552 | 463/18723 | 2.61e-26 | 7.88e-24 | 323 |
GO:003090118 | Esophagus | ESCC | midbrain development | 58/8552 | 90/18723 | 2.52e-04 | 1.55e-03 | 58 |
GO:00064824 | Esophagus | ESCC | protein demethylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00082144 | Esophagus | ESCC | protein dealkylation | 24/8552 | 33/18723 | 1.50e-03 | 7.06e-03 | 24 |
GO:00165773 | Esophagus | ESCC | histone demethylation | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00700763 | Esophagus | ESCC | histone lysine demethylation | 20/8552 | 28/18723 | 5.23e-03 | 1.97e-02 | 20 |
GO:00165703 | Liver | NAFLD | histone modification | 90/1882 | 463/18723 | 5.74e-10 | 1.28e-07 | 90 |
GO:0070076 | Liver | NAFLD | histone lysine demethylation | 10/1882 | 28/18723 | 2.46e-04 | 4.09e-03 | 10 |
GO:0016577 | Liver | NAFLD | histone demethylation | 10/1882 | 31/18723 | 6.28e-04 | 8.21e-03 | 10 |
GO:0006482 | Liver | NAFLD | protein demethylation | 10/1882 | 33/18723 | 1.09e-03 | 1.27e-02 | 10 |
GO:0008214 | Liver | NAFLD | protein dealkylation | 10/1882 | 33/18723 | 1.09e-03 | 1.27e-02 | 10 |
GO:00309017 | Liver | NAFLD | midbrain development | 19/1882 | 90/18723 | 1.35e-03 | 1.52e-02 | 19 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
KDM7A | CD8TEXP | Breast | Precancer | TMEM204,GLO1,THADA, etc. | 4.58e-02 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDM7A | SNV | Missense_Mutation | c.1553A>G | p.Asn518Ser | p.N518S | Q6ZMT4 | protein_coding | tolerated(1) | benign(0) | TCGA-A2-A04T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
KDM7A | SNV | Missense_Mutation | c.1652N>G | p.Ser551Cys | p.S551C | Q6ZMT4 | protein_coding | deleterious(0.03) | possibly_damaging(0.628) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KDM7A | SNV | Missense_Mutation | novel | c.1831A>G | p.Arg611Gly | p.R611G | Q6ZMT4 | protein_coding | tolerated(0.13) | benign(0) | TCGA-D8-A1JL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KDM7A | insertion | In_Frame_Ins | novel | c.2459_2460insAACATATGGCACACTCAAGGACAG | p.Asp820delinsGluThrTyrGlyThrLeuLysAspSer | p.D820delinsETYGTLKDS | Q6ZMT4 | protein_coding | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
KDM7A | deletion | Frame_Shift_Del | c.914delA | p.Lys305SerfsTer17 | p.K305Sfs*17 | Q6ZMT4 | protein_coding | TCGA-E9-A1NE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |||
KDM7A | SNV | Missense_Mutation | novel | c.787A>G | p.Lys263Glu | p.K263E | Q6ZMT4 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KDM7A | SNV | Missense_Mutation | c.1369G>C | p.Asp457His | p.D457H | Q6ZMT4 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-EK-A2RA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
KDM7A | SNV | Missense_Mutation | rs758963637 | c.2548N>A | p.Gly850Ser | p.G850S | Q6ZMT4 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
KDM7A | SNV | Missense_Mutation | novel | c.997N>C | p.Asp333His | p.D333H | Q6ZMT4 | protein_coding | deleterious(0) | probably_damaging(0.943) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KDM7A | SNV | Missense_Mutation | c.2755G>A | p.Ala919Thr | p.A919T | Q6ZMT4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A6-2683-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | irinotecan | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
80853 | KDM7A | ENZYME | inhibitor | 178103604 |
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