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Gene: JAZF1 |
Gene summary for JAZF1 |
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Gene information | Species | Human | Gene symbol | JAZF1 | Gene ID | 221895 |
Gene name | JAZF zinc finger 1 | |
Gene Alias | TIP27 | |
Cytomap | 7p15.2-p15.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q86VZ6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
221895 | JAZF1 | NEOLP-1 | Human | Oral cavity | NEOLP | 3.71e-16 | 5.90e-01 | -0.0194 |
221895 | JAZF1 | NEOLP-2 | Human | Oral cavity | NEOLP | 3.05e-05 | 2.92e-01 | -0.0196 |
221895 | JAZF1 | NEOLP-3 | Human | Oral cavity | NEOLP | 6.23e-06 | 2.76e-01 | -0.0191 |
221895 | JAZF1 | SYSMH1 | Human | Oral cavity | OSCC | 2.39e-02 | -2.17e-02 | 0.1127 |
221895 | JAZF1 | HTA12-15-2 | Human | Pancreas | PDAC | 3.80e-11 | 6.57e-01 | 0.2315 |
221895 | JAZF1 | HTA12-16-2 | Human | Pancreas | PDAC | 1.95e-02 | 7.66e-01 | 0.0535 |
221895 | JAZF1 | HTA12-23-1 | Human | Pancreas | PDAC | 7.43e-15 | 1.19e+00 | 0.3405 |
221895 | JAZF1 | HTA12-25-1 | Human | Pancreas | PDAC | 1.61e-14 | 9.93e-01 | 0.313 |
221895 | JAZF1 | HTA12-26-1 | Human | Pancreas | PDAC | 9.56e-30 | 1.19e+00 | 0.3728 |
221895 | JAZF1 | HTA12-29-1 | Human | Pancreas | PDAC | 1.54e-63 | 1.20e+00 | 0.3722 |
221895 | JAZF1 | HTA12-32-1 | Human | Pancreas | PDAC | 2.54e-06 | 1.07e+00 | 0.3624 |
221895 | JAZF1 | HTA12-9-1 | Human | Pancreas | PDAC | 2.54e-02 | 4.25e-01 | 0.1532 |
221895 | JAZF1 | HTA12-9-2 | Human | Pancreas | PDAC | 1.17e-07 | 5.39e-01 | 0.0835 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JAZF1 | SNV | Missense_Mutation | rs761995472 | c.701C>T | p.Ser234Leu | p.S234L | Q86VZ6 | protein_coding | tolerated_low_confidence(0.06) | probably_damaging(0.964) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
JAZF1 | SNV | Missense_Mutation | c.190N>A | p.Phe64Ile | p.F64I | Q86VZ6 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
JAZF1 | SNV | Missense_Mutation | c.608G>A | p.Arg203His | p.R203H | Q86VZ6 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
JAZF1 | SNV | Missense_Mutation | c.254N>T | p.Ser85Leu | p.S85L | Q86VZ6 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
JAZF1 | SNV | Missense_Mutation | c.723N>A | p.Met241Ile | p.M241I | Q86VZ6 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
JAZF1 | SNV | Missense_Mutation | c.305G>A | p.Arg102His | p.R102H | Q86VZ6 | protein_coding | tolerated(0.11) | probably_damaging(0.989) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
JAZF1 | SNV | Missense_Mutation | novel | c.206N>T | p.Ala69Val | p.A69V | Q86VZ6 | protein_coding | tolerated(0.09) | probably_damaging(0.98) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
JAZF1 | SNV | Missense_Mutation | c.305G>A | p.Arg102His | p.R102H | Q86VZ6 | protein_coding | tolerated(0.11) | probably_damaging(0.989) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
JAZF1 | SNV | Missense_Mutation | rs562255429 | c.667C>T | p.Arg223Trp | p.R223W | Q86VZ6 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
JAZF1 | SNV | Missense_Mutation | c.304C>T | p.Arg102Cys | p.R102C | Q86VZ6 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-D1-A17B-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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