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Gene: IRF2BPL |
Gene summary for IRF2BPL |
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Gene information | Species | Human | Gene symbol | IRF2BPL | Gene ID | 64207 |
Gene name | interferon regulatory factor 2 binding protein like | |
Gene Alias | C14orf4 | |
Cytomap | 14q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9H1B7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64207 | IRF2BPL | cSCC_p10 | Human | Skin | cSCC | 1.23e-04 | 3.67e-01 | -0.2095 |
64207 | IRF2BPL | cSCC_p8 | Human | Skin | cSCC | 6.32e-03 | 7.86e-02 | -0.1971 |
64207 | IRF2BPL | male-WTA | Human | Thyroid | PTC | 8.16e-40 | 4.32e-01 | 0.1037 |
64207 | IRF2BPL | PTC01 | Human | Thyroid | PTC | 8.77e-08 | 1.97e-01 | 0.1899 |
64207 | IRF2BPL | PTC04 | Human | Thyroid | PTC | 3.65e-07 | 1.10e-01 | 0.1927 |
64207 | IRF2BPL | PTC05 | Human | Thyroid | PTC | 4.83e-30 | 1.01e+00 | 0.2065 |
64207 | IRF2BPL | PTC06 | Human | Thyroid | PTC | 1.44e-31 | 7.38e-01 | 0.2057 |
64207 | IRF2BPL | PTC07 | Human | Thyroid | PTC | 1.14e-18 | 3.17e-01 | 0.2044 |
64207 | IRF2BPL | ATC09 | Human | Thyroid | ATC | 1.48e-08 | 3.14e-01 | 0.2871 |
64207 | IRF2BPL | ATC11 | Human | Thyroid | ATC | 1.58e-10 | 5.83e-01 | 0.3386 |
64207 | IRF2BPL | ATC12 | Human | Thyroid | ATC | 4.52e-11 | 2.48e-01 | 0.34 |
64207 | IRF2BPL | ATC13 | Human | Thyroid | ATC | 2.65e-19 | 4.53e-01 | 0.34 |
64207 | IRF2BPL | ATC1 | Human | Thyroid | ATC | 5.16e-10 | 3.74e-01 | 0.2878 |
64207 | IRF2BPL | ATC3 | Human | Thyroid | ATC | 4.05e-09 | 4.41e-01 | 0.338 |
64207 | IRF2BPL | ATC4 | Human | Thyroid | ATC | 1.15e-19 | 3.41e-01 | 0.34 |
64207 | IRF2BPL | ATC5 | Human | Thyroid | ATC | 5.58e-25 | 4.86e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IRF2BPL | SNV | Missense_Mutation | novel | c.1129N>C | p.Asp377His | p.D377H | Q9H1B7 | protein_coding | deleterious(0) | probably_damaging(0.959) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
IRF2BPL | SNV | Missense_Mutation | c.2114N>T | p.Ser705Phe | p.S705F | Q9H1B7 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IRF2BPL | SNV | Missense_Mutation | novel | c.1408N>C | p.Asp470His | p.D470H | Q9H1B7 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
IRF2BPL | SNV | Missense_Mutation | novel | c.1447N>T | p.Arg483Cys | p.R483C | Q9H1B7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IRF2BPL | SNV | Missense_Mutation | rs749273166 | c.1396N>A | p.His466Asn | p.H466N | Q9H1B7 | protein_coding | deleterious(0.02) | benign(0.091) | TCGA-EK-A3GN-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
IRF2BPL | deletion | Frame_Shift_Del | novel | c.224_305delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Pro75ArgfsTer50 | p.P75Rfs*50 | Q9H1B7 | protein_coding | TCGA-MA-AA3Y-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
IRF2BPL | SNV | Missense_Mutation | c.1298G>T | p.Ser433Ile | p.S433I | Q9H1B7 | protein_coding | deleterious(0) | benign(0.403) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
IRF2BPL | SNV | Missense_Mutation | rs147559103 | c.953N>T | p.Ser318Leu | p.S318L | Q9H1B7 | protein_coding | tolerated(0.48) | benign(0.089) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IRF2BPL | SNV | Missense_Mutation | c.1448N>A | p.Arg483His | p.R483H | Q9H1B7 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
IRF2BPL | SNV | Missense_Mutation | novel | c.1384N>C | p.Tyr462His | p.Y462H | Q9H1B7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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