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Gene: IFNGR2 |
Gene summary for IFNGR2 |
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Gene information | Species | Human | Gene symbol | IFNGR2 | Gene ID | 3460 |
Gene name | interferon gamma receptor 2 | |
Gene Alias | AF-1 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0001774 | UniProtAcc | E7EUY1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3460 | IFNGR2 | HCC1_Meng | Human | Liver | HCC | 1.81e-72 | 1.46e-01 | 0.0246 |
3460 | IFNGR2 | HCC2_Meng | Human | Liver | HCC | 1.83e-44 | 2.95e-01 | 0.0107 |
3460 | IFNGR2 | cirrhotic2 | Human | Liver | Cirrhotic | 4.59e-06 | 1.08e-01 | 0.0201 |
3460 | IFNGR2 | HCC1 | Human | Liver | HCC | 1.76e-04 | 2.47e+00 | 0.5336 |
3460 | IFNGR2 | HCC2 | Human | Liver | HCC | 9.30e-04 | 2.19e+00 | 0.5341 |
3460 | IFNGR2 | Pt13.b | Human | Liver | HCC | 8.23e-13 | 1.94e-01 | 0.0251 |
3460 | IFNGR2 | S014 | Human | Liver | HCC | 2.98e-06 | 4.86e-01 | 0.2254 |
3460 | IFNGR2 | S015 | Human | Liver | HCC | 7.34e-06 | 5.74e-01 | 0.2375 |
3460 | IFNGR2 | S016 | Human | Liver | HCC | 2.49e-10 | 5.85e-01 | 0.2243 |
3460 | IFNGR2 | S027 | Human | Liver | HCC | 5.51e-09 | 1.24e+00 | 0.2446 |
3460 | IFNGR2 | S028 | Human | Liver | HCC | 1.62e-29 | 1.50e+00 | 0.2503 |
3460 | IFNGR2 | S029 | Human | Liver | HCC | 6.96e-26 | 1.75e+00 | 0.2581 |
3460 | IFNGR2 | TD9 | Human | Lung | IAC | 1.88e-04 | 5.04e-01 | 0.088 |
3460 | IFNGR2 | RNA-P17T-P17T-2 | Human | Lung | IAC | 3.02e-04 | 7.06e-01 | 0.3371 |
3460 | IFNGR2 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.30e-03 | 6.41e-01 | 0.343 |
3460 | IFNGR2 | RNA-P17T-P17T-6 | Human | Lung | IAC | 3.91e-02 | 5.82e-01 | 0.3385 |
3460 | IFNGR2 | RNA-P17T-P17T-8 | Human | Lung | IAC | 2.06e-05 | 6.64e-01 | 0.3329 |
3460 | IFNGR2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 4.43e-03 | 1.17e-01 | -0.0166 |
3460 | IFNGR2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.25e-07 | 2.10e-01 | -0.0132 |
3460 | IFNGR2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.83e-08 | 1.68e-01 | -0.013 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032411 | Colorectum | AD | positive regulation of transporter activity | 37/3918 | 120/18723 | 6.82e-03 | 4.22e-02 | 37 |
GO:00324111 | Colorectum | SER | positive regulation of transporter activity | 31/2897 | 120/18723 | 2.25e-03 | 2.16e-02 | 31 |
GO:0032409 | Colorectum | SER | regulation of transporter activity | 65/2897 | 310/18723 | 5.71e-03 | 4.19e-02 | 65 |
GO:00324091 | Colorectum | MSS | regulation of transporter activity | 78/3467 | 310/18723 | 2.09e-03 | 1.78e-02 | 78 |
GO:0034764 | Colorectum | MSS | positive regulation of transmembrane transport | 58/3467 | 219/18723 | 2.19e-03 | 1.83e-02 | 58 |
GO:00324112 | Colorectum | MSS | positive regulation of transporter activity | 35/3467 | 120/18723 | 2.95e-03 | 2.28e-02 | 35 |
GO:0022898 | Colorectum | MSS | regulation of transmembrane transporter activity | 70/3467 | 278/18723 | 3.36e-03 | 2.54e-02 | 70 |
GO:0060333 | Colorectum | MSS | interferon-gamma-mediated signaling pathway | 11/3467 | 27/18723 | 6.03e-03 | 4.04e-02 | 11 |
GO:0032412 | Colorectum | MSS | regulation of ion transmembrane transporter activity | 66/3467 | 267/18723 | 6.72e-03 | 4.38e-02 | 66 |
GO:00347641 | Colorectum | FAP | positive regulation of transmembrane transport | 53/2622 | 219/18723 | 3.54e-05 | 7.75e-04 | 53 |
GO:00228981 | Colorectum | FAP | regulation of transmembrane transporter activity | 62/2622 | 278/18723 | 1.09e-04 | 1.80e-03 | 62 |
GO:00324121 | Colorectum | FAP | regulation of ion transmembrane transporter activity | 60/2622 | 267/18723 | 1.12e-04 | 1.84e-03 | 60 |
GO:00324092 | Colorectum | FAP | regulation of transporter activity | 67/2622 | 310/18723 | 1.59e-04 | 2.43e-03 | 67 |
GO:0043270 | Colorectum | FAP | positive regulation of ion transport | 58/2622 | 275/18723 | 7.98e-04 | 8.36e-03 | 58 |
GO:0032414 | Colorectum | FAP | positive regulation of ion transmembrane transporter activity | 28/2622 | 109/18723 | 8.64e-04 | 8.87e-03 | 28 |
GO:00324113 | Colorectum | FAP | positive regulation of transporter activity | 29/2622 | 120/18723 | 1.97e-03 | 1.65e-02 | 29 |
GO:0034767 | Colorectum | FAP | positive regulation of ion transmembrane transport | 37/2622 | 167/18723 | 2.74e-03 | 2.12e-02 | 37 |
GO:1904062 | Colorectum | FAP | regulation of cation transmembrane transport | 69/2622 | 357/18723 | 3.06e-03 | 2.30e-02 | 69 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa040662 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa040663 | Colorectum | SER | HIF-1 signaling pathway | 36/1580 | 109/8465 | 2.27e-04 | 2.15e-03 | 1.56e-03 | 36 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa040664 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa040665 | Colorectum | MSS | HIF-1 signaling pathway | 39/1875 | 109/8465 | 7.61e-04 | 5.00e-03 | 3.06e-03 | 39 |
hsa040666 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
hsa040667 | Colorectum | FAP | HIF-1 signaling pathway | 38/1404 | 109/8465 | 2.43e-06 | 4.28e-05 | 2.60e-05 | 38 |
hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0406629 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
hsa0514525 | Esophagus | ESCC | Toxoplasmosis | 76/4205 | 112/8465 | 6.83e-05 | 2.90e-04 | 1.48e-04 | 76 |
hsa051527 | Esophagus | ESCC | Tuberculosis | 111/4205 | 180/8465 | 7.14e-04 | 2.32e-03 | 1.19e-03 | 111 |
hsa052356 | Esophagus | ESCC | PD-L1 expression and PD-1 checkpoint pathway in cancer | 58/4205 | 89/8465 | 2.19e-03 | 6.16e-03 | 3.16e-03 | 58 |
hsa051425 | Esophagus | ESCC | Chagas disease | 65/4205 | 102/8465 | 2.81e-03 | 7.59e-03 | 3.89e-03 | 65 |
hsa046599 | Esophagus | ESCC | Th17 cell differentiation | 68/4205 | 108/8465 | 3.53e-03 | 9.30e-03 | 4.76e-03 | 68 |
hsa046585 | Esophagus | ESCC | Th1 and Th2 cell differentiation | 58/4205 | 92/8465 | 6.49e-03 | 1.60e-02 | 8.19e-03 | 58 |
hsa0516435 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa04066113 | Esophagus | ESCC | HIF-1 signaling pathway | 75/4205 | 109/8465 | 3.66e-05 | 1.68e-04 | 8.60e-05 | 75 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Breast | DCIS |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Breast | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Breast | IDC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | CC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Cervix | Precancer |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | AEH |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | EEC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Endometrium | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | GC | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | GC | GC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | ADJ |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | OSCC |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | HNSCC | Precancer |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Liver | Healthy |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Liver | Precancer |
IFNG | IFNGR1_IFNGR2 | IFNG_IFNGR1_IFNGR2 | IFN-II | Lung | AAH |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFNGR2 | SNV | Missense_Mutation | novel | c.319N>A | p.Gln107Lys | p.Q107K | protein_coding | tolerated(0.57) | benign(0.006) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | |
IFNGR2 | SNV | Missense_Mutation | rs142997921 | c.566C>T | p.Thr189Met | p.T189M | protein_coding | tolerated(0.12) | benign(0.025) | TCGA-E2-A15S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
IFNGR2 | deletion | Frame_Shift_Del | novel | c.434delN | p.Val146Ter | p.V146* | protein_coding | TCGA-BH-A0BZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | CR | |||
IFNGR2 | SNV | Missense_Mutation | novel | c.946N>T | p.Asp316Tyr | p.D316Y | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IFNGR2 | SNV | Missense_Mutation | c.605N>T | p.Gly202Val | p.G202V | protein_coding | deleterious(0.02) | benign(0.265) | TCGA-RA-A741-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
IFNGR2 | insertion | Frame_Shift_Ins | novel | c.665_666dupAA | p.Pro223AsnfsTer27 | p.P223Nfs*27 | protein_coding | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
IFNGR2 | SNV | Missense_Mutation | c.534N>A | p.Phe178Leu | p.F178L | protein_coding | tolerated(0.27) | benign(0.111) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
IFNGR2 | SNV | Missense_Mutation | rs760780330 | c.404N>A | p.Arg135Gln | p.R135Q | protein_coding | tolerated(0.09) | possibly_damaging(0.696) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
IFNGR2 | SNV | Missense_Mutation | rs369753667 | c.775N>C | p.Asp259His | p.D259H | protein_coding | deleterious(0.01) | possibly_damaging(0.788) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
IFNGR2 | SNV | Missense_Mutation | rs750400339 | c.827N>T | p.Ser276Leu | p.S276L | protein_coding | tolerated(1) | benign(0) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3460 | IFNGR2 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | agonist | CHEMBL1201564 | INTERFERON GAMMA-1B | |
3460 | IFNGR2 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | INTERFERON GAMMA-1B | |||
3460 | IFNGR2 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | IFN-GAMMA | INTERFERON GAMMA-1B | ||
3460 | IFNGR2 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | Interferon gamma-1b | |||
3460 | IFNGR2 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME | INTERFERON GAMMA-1B |
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