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Gene: IFI27L2 |
Gene summary for IFI27L2 |
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Gene information | Species | Human | Gene symbol | IFI27L2 | Gene ID | 83982 |
Gene name | interferon alpha inducible protein 27 like 2 | |
Gene Alias | FAM14A | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q9H2X8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83982 | IFI27L2 | P75T-E | Human | Esophagus | ESCC | 9.07e-25 | 9.30e-01 | 0.1125 |
83982 | IFI27L2 | P76T-E | Human | Esophagus | ESCC | 1.08e-19 | 6.26e-01 | 0.1207 |
83982 | IFI27L2 | P79T-E | Human | Esophagus | ESCC | 1.56e-10 | 3.36e-01 | 0.1154 |
83982 | IFI27L2 | P80T-E | Human | Esophagus | ESCC | 1.26e-32 | 1.32e+00 | 0.155 |
83982 | IFI27L2 | P82T-E | Human | Esophagus | ESCC | 1.36e-14 | 1.38e+00 | 0.1072 |
83982 | IFI27L2 | P83T-E | Human | Esophagus | ESCC | 1.10e-59 | 2.01e+00 | 0.1738 |
83982 | IFI27L2 | P89T-E | Human | Esophagus | ESCC | 4.28e-34 | 2.96e+00 | 0.1752 |
83982 | IFI27L2 | P91T-E | Human | Esophagus | ESCC | 6.37e-29 | 3.77e+00 | 0.1828 |
83982 | IFI27L2 | P107T-E | Human | Esophagus | ESCC | 9.30e-68 | 1.79e+00 | 0.171 |
83982 | IFI27L2 | P126T-E | Human | Esophagus | ESCC | 8.56e-06 | 1.33e+00 | 0.1125 |
83982 | IFI27L2 | P127T-E | Human | Esophagus | ESCC | 2.14e-13 | 2.95e-01 | 0.0826 |
83982 | IFI27L2 | P128T-E | Human | Esophagus | ESCC | 2.31e-08 | 4.72e-01 | 0.1241 |
83982 | IFI27L2 | P130T-E | Human | Esophagus | ESCC | 5.13e-14 | 4.79e-01 | 0.1676 |
83982 | IFI27L2 | S43 | Human | Liver | Cirrhotic | 5.66e-03 | -2.28e-01 | -0.0187 |
83982 | IFI27L2 | HCC1_Meng | Human | Liver | HCC | 9.68e-29 | -1.21e-01 | 0.0246 |
83982 | IFI27L2 | HCC2_Meng | Human | Liver | HCC | 2.91e-59 | 4.17e-01 | 0.0107 |
83982 | IFI27L2 | cirrhotic1 | Human | Liver | Cirrhotic | 3.24e-11 | 1.46e-01 | 0.0202 |
83982 | IFI27L2 | cirrhotic2 | Human | Liver | Cirrhotic | 3.03e-22 | 2.98e-01 | 0.0201 |
83982 | IFI27L2 | cirrhotic3 | Human | Liver | Cirrhotic | 1.76e-19 | 3.49e-01 | 0.0215 |
83982 | IFI27L2 | HCC2 | Human | Liver | HCC | 1.06e-08 | 4.16e+00 | 0.5341 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFI27L2 | SNV | Missense_Mutation | novel | c.50N>T | p.Gly17Val | p.G17V | Q9H2X8 | protein_coding | tolerated(0.13) | benign(0.012) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
IFI27L2 | SNV | Missense_Mutation | rs765630307 | c.35N>A | p.Gly12Glu | p.G12E | Q9H2X8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A94W-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IFI27L2 | SNV | Missense_Mutation | novel | c.274N>G | p.Asn92Asp | p.N92D | Q9H2X8 | protein_coding | tolerated(0.55) | benign(0) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFI27L2 | SNV | Missense_Mutation | c.320N>C | p.Asp107Ala | p.D107A | Q9H2X8 | protein_coding | tolerated(0.4) | benign(0.011) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
IFI27L2 | SNV | Missense_Mutation | rs763009285 | c.133N>A | p.Ala45Thr | p.A45T | Q9H2X8 | protein_coding | tolerated(0.18) | possibly_damaging(0.803) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFI27L2 | SNV | Missense_Mutation | novel | c.95G>A | p.Gly32Glu | p.G32E | Q9H2X8 | protein_coding | deleterious(0.01) | possibly_damaging(0.765) | TCGA-EI-6506-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
IFI27L2 | SNV | Missense_Mutation | rs774005783 | c.53C>T | p.Ala18Val | p.A18V | Q9H2X8 | protein_coding | deleterious(0.01) | benign(0.271) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
IFI27L2 | SNV | Missense_Mutation | novel | c.263C>T | p.Ala88Val | p.A88V | Q9H2X8 | protein_coding | deleterious(0.01) | probably_damaging(0.945) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
IFI27L2 | SNV | Missense_Mutation | rs755537199 | c.100G>A | p.Ala34Thr | p.A34T | Q9H2X8 | protein_coding | tolerated(0.27) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
IFI27L2 | SNV | Missense_Mutation | rs200116572 | c.104C>T | p.Ala35Val | p.A35V | Q9H2X8 | protein_coding | deleterious(0.05) | probably_damaging(0.94) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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