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Gene: HSDL2 |
Gene summary for HSDL2 |
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Gene information | Species | Human | Gene symbol | HSDL2 | Gene ID | 84263 |
Gene name | hydroxysteroid dehydrogenase like 2 | |
Gene Alias | C9orf99 | |
Cytomap | 9q32 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A0A024R159 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84263 | HSDL2 | P75T-E | Human | Esophagus | ESCC | 4.00e-36 | 7.23e-01 | 0.1125 |
84263 | HSDL2 | P76T-E | Human | Esophagus | ESCC | 2.77e-07 | 1.86e-01 | 0.1207 |
84263 | HSDL2 | P79T-E | Human | Esophagus | ESCC | 1.79e-16 | 3.43e-01 | 0.1154 |
84263 | HSDL2 | P80T-E | Human | Esophagus | ESCC | 1.90e-16 | 6.01e-01 | 0.155 |
84263 | HSDL2 | P82T-E | Human | Esophagus | ESCC | 1.47e-11 | 5.35e-01 | 0.1072 |
84263 | HSDL2 | P83T-E | Human | Esophagus | ESCC | 1.09e-27 | 7.95e-01 | 0.1738 |
84263 | HSDL2 | P84T-E | Human | Esophagus | ESCC | 1.69e-03 | 3.82e-01 | 0.0933 |
84263 | HSDL2 | P89T-E | Human | Esophagus | ESCC | 7.27e-09 | 5.12e-01 | 0.1752 |
84263 | HSDL2 | P91T-E | Human | Esophagus | ESCC | 1.13e-05 | 7.35e-01 | 0.1828 |
84263 | HSDL2 | P107T-E | Human | Esophagus | ESCC | 3.80e-29 | 7.35e-01 | 0.171 |
84263 | HSDL2 | P127T-E | Human | Esophagus | ESCC | 1.79e-12 | 1.88e-01 | 0.0826 |
84263 | HSDL2 | P128T-E | Human | Esophagus | ESCC | 1.32e-15 | 6.04e-01 | 0.1241 |
84263 | HSDL2 | P130T-E | Human | Esophagus | ESCC | 6.33e-32 | 7.36e-01 | 0.1676 |
84263 | HSDL2 | NAFLD1 | Human | Liver | NAFLD | 4.08e-06 | 7.84e-01 | -0.04 |
84263 | HSDL2 | S43 | Human | Liver | Cirrhotic | 2.07e-04 | -1.12e-01 | -0.0187 |
84263 | HSDL2 | HCC1_Meng | Human | Liver | HCC | 2.19e-61 | -9.17e-02 | 0.0246 |
84263 | HSDL2 | HCC2_Meng | Human | Liver | HCC | 4.54e-16 | -1.39e-01 | 0.0107 |
84263 | HSDL2 | HCC1 | Human | Liver | HCC | 3.27e-13 | 4.20e+00 | 0.5336 |
84263 | HSDL2 | HCC2 | Human | Liver | HCC | 1.05e-11 | 4.05e+00 | 0.5341 |
84263 | HSDL2 | Pt13.b | Human | Liver | HCC | 3.90e-03 | -1.00e-01 | 0.0251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSDL2 | SNV | Missense_Mutation | novel | c.1094N>T | p.Ala365Val | p.A365V | Q6YN16 | protein_coding | tolerated(0.09) | benign(0.094) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HSDL2 | SNV | Missense_Mutation | c.247N>C | p.Ala83Pro | p.A83P | Q6YN16 | protein_coding | tolerated(0.25) | benign(0.121) | TCGA-B6-A0RO-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HSDL2 | SNV | Missense_Mutation | c.1250N>C | p.Arg417Thr | p.R417T | Q6YN16 | protein_coding | deleterious(0) | benign(0.103) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
HSDL2 | SNV | Missense_Mutation | c.889N>C | p.Glu297Gln | p.E297Q | Q6YN16 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-4J-AA1J-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HSDL2 | SNV | Missense_Mutation | c.1142C>T | p.Ser381Leu | p.S381L | Q6YN16 | protein_coding | deleterious(0) | benign(0.338) | TCGA-DS-A0VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
HSDL2 | SNV | Missense_Mutation | novel | c.508N>T | p.Ile170Phe | p.I170F | Q6YN16 | protein_coding | deleterious(0) | benign(0.387) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HSDL2 | SNV | Missense_Mutation | c.1237N>G | p.Gln413Glu | p.Q413E | Q6YN16 | protein_coding | tolerated(0.22) | benign(0.108) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HSDL2 | SNV | Missense_Mutation | c.1159A>G | p.Thr387Ala | p.T387A | Q6YN16 | protein_coding | tolerated(0.23) | benign(0.254) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HSDL2 | SNV | Missense_Mutation | c.673N>A | p.Ala225Thr | p.A225T | Q6YN16 | protein_coding | deleterious(0.01) | possibly_damaging(0.822) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HSDL2 | SNV | Missense_Mutation | c.660N>C | p.Lys220Asn | p.K220N | Q6YN16 | protein_coding | deleterious(0.03) | benign(0.013) | TCGA-CL-4957-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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