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Gene: HLA-DPA1 |
Gene summary for HLA-DPA1 |
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Gene information | Species | Human | Gene symbol | HLA-DPA1 | Gene ID | 3113 |
Gene name | major histocompatibility complex, class II, DP alpha 1 | |
Gene Alias | DP(W3) | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P20036 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3113 | HLA-DPA1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.39e-04 | -5.97e-01 | 0.343 |
3113 | HLA-DPA1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 6.20e-18 | -3.17e-02 | -0.2116 |
3113 | HLA-DPA1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 1.55e-06 | -7.44e-02 | -0.1941 |
3113 | HLA-DPA1 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 1.17e-05 | -5.78e-02 | -0.2107 |
3113 | HLA-DPA1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.21e-16 | 8.18e-02 | -0.2119 |
3113 | HLA-DPA1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.99e-05 | -8.01e-01 | 0.1829 |
3113 | HLA-DPA1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 4.11e-04 | -6.99e-01 | 0.1835 |
3113 | HLA-DPA1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.95e-08 | -7.73e-01 | 0.1859 |
3113 | HLA-DPA1 | RNA-P6T1-P6T1-2 | Human | Lung | MIAC | 3.75e-03 | -8.59e-01 | -0.0186 |
3113 | HLA-DPA1 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 1.76e-03 | -6.76e-01 | -0.0296 |
3113 | HLA-DPA1 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 1.81e-03 | -7.60e-01 | -0.0263 |
3113 | HLA-DPA1 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 7.44e-14 | -4.16e-01 | -0.0166 |
3113 | HLA-DPA1 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.01e-23 | -3.09e-01 | -0.0132 |
3113 | HLA-DPA1 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 3.56e-19 | -3.77e-01 | -0.013 |
3113 | HLA-DPA1 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.93e-12 | -5.26e-01 | -0.0121 |
3113 | HLA-DPA1 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.65e-06 | 6.83e-02 | -0.0961 |
3113 | HLA-DPA1 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 7.03e-05 | -1.10e-01 | -0.0876 |
3113 | HLA-DPA1 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 9.33e-09 | -2.97e-02 | -0.0822 |
3113 | HLA-DPA1 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 1.62e-03 | -2.59e-01 | -0.0809 |
3113 | HLA-DPA1 | C04 | Human | Oral cavity | OSCC | 4.44e-17 | 1.41e+00 | 0.2633 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004800213 | Breast | IDC | antigen processing and presentation of peptide antigen | 18/1434 | 62/18723 | 5.28e-07 | 2.59e-05 | 18 |
GO:004578514 | Breast | IDC | positive regulation of cell adhesion | 62/1434 | 437/18723 | 1.70e-06 | 7.16e-05 | 62 |
GO:000250112 | Breast | IDC | peptide antigen assembly with MHC protein complex | 9/1434 | 18/18723 | 2.28e-06 | 9.05e-05 | 9 |
GO:000247813 | Breast | IDC | antigen processing and presentation of exogenous peptide antigen | 13/1434 | 38/18723 | 2.60e-06 | 1.01e-04 | 13 |
GO:000239612 | Breast | IDC | MHC protein complex assembly | 9/1434 | 19/18723 | 4.03e-06 | 1.43e-04 | 9 |
GO:00023997 | Breast | IDC | MHC class II protein complex assembly | 8/1434 | 16/18723 | 8.56e-06 | 2.47e-04 | 8 |
GO:00025037 | Breast | IDC | peptide antigen assembly with MHC class II protein complex | 8/1434 | 16/18723 | 8.56e-06 | 2.47e-04 | 8 |
GO:004211012 | Breast | IDC | T cell activation | 64/1434 | 487/18723 | 1.49e-05 | 3.77e-04 | 64 |
GO:005086311 | Breast | IDC | regulation of T cell activation | 47/1434 | 329/18723 | 2.49e-05 | 5.91e-04 | 47 |
GO:000181911 | Breast | IDC | positive regulation of cytokine production | 61/1434 | 467/18723 | 2.81e-05 | 6.58e-04 | 61 |
GO:00024957 | Breast | IDC | antigen processing and presentation of peptide antigen via MHC class II | 11/1434 | 34/18723 | 2.81e-05 | 6.58e-04 | 11 |
GO:001988413 | Breast | IDC | antigen processing and presentation of exogenous antigen | 13/1434 | 47/18723 | 3.53e-05 | 8.08e-04 | 13 |
GO:005087011 | Breast | IDC | positive regulation of T cell activation | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:001988613 | Breast | IDC | antigen processing and presentation of exogenous peptide antigen via MHC class II | 10/1434 | 30/18723 | 4.87e-05 | 1.07e-03 | 10 |
GO:00025047 | Breast | IDC | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 11/1434 | 36/18723 | 5.13e-05 | 1.10e-03 | 11 |
GO:000715912 | Breast | IDC | leukocyte cell-cell adhesion | 49/1434 | 371/18723 | 1.27e-04 | 2.33e-03 | 49 |
GO:00198829 | Breast | IDC | antigen processing and presentation | 20/1434 | 106/18723 | 1.41e-04 | 2.49e-03 | 20 |
GO:190303911 | Breast | IDC | positive regulation of leukocyte cell-cell adhesion | 35/1434 | 239/18723 | 1.58e-04 | 2.73e-03 | 35 |
GO:190303711 | Breast | IDC | regulation of leukocyte cell-cell adhesion | 45/1434 | 336/18723 | 1.72e-04 | 2.92e-03 | 45 |
GO:002240712 | Breast | IDC | regulation of cell-cell adhesion | 55/1434 | 448/18723 | 3.43e-04 | 5.07e-03 | 55 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516922 | Breast | IDC | Epstein-Barr virus infection | 45/867 | 202/8465 | 3.16e-07 | 6.05e-06 | 4.52e-06 | 45 |
hsa0461223 | Breast | IDC | Antigen processing and presentation | 24/867 | 78/8465 | 4.61e-07 | 8.33e-06 | 6.23e-06 | 24 |
hsa0414522 | Breast | IDC | Phagosome | 34/867 | 152/8465 | 8.00e-06 | 9.99e-05 | 7.48e-05 | 34 |
hsa0541623 | Breast | IDC | Viral myocarditis | 18/867 | 60/8465 | 1.85e-05 | 2.01e-04 | 1.50e-04 | 18 |
hsa0516624 | Breast | IDC | Human T-cell leukemia virus 1 infection | 40/867 | 222/8465 | 2.52e-04 | 2.21e-03 | 1.66e-03 | 40 |
hsa0532321 | Breast | IDC | Rheumatoid arthritis | 21/867 | 93/8465 | 3.69e-04 | 3.15e-03 | 2.36e-03 | 21 |
hsa0494014 | Breast | IDC | Type I diabetes mellitus | 12/867 | 43/8465 | 9.40e-04 | 7.28e-03 | 5.44e-03 | 12 |
hsa0533012 | Breast | IDC | Allograft rejection | 11/867 | 38/8465 | 1.09e-03 | 8.26e-03 | 6.18e-03 | 11 |
hsa0533210 | Breast | IDC | Graft-versus-host disease | 11/867 | 42/8465 | 2.66e-03 | 1.80e-02 | 1.35e-02 | 11 |
hsa0514012 | Breast | IDC | Leishmaniasis | 16/867 | 77/8465 | 4.35e-03 | 2.57e-02 | 1.92e-02 | 16 |
hsa0532010 | Breast | IDC | Autoimmune thyroid disease | 12/867 | 53/8465 | 6.29e-03 | 3.30e-02 | 2.47e-02 | 12 |
hsa0516932 | Breast | IDC | Epstein-Barr virus infection | 45/867 | 202/8465 | 3.16e-07 | 6.05e-06 | 4.52e-06 | 45 |
hsa0461233 | Breast | IDC | Antigen processing and presentation | 24/867 | 78/8465 | 4.61e-07 | 8.33e-06 | 6.23e-06 | 24 |
hsa0414532 | Breast | IDC | Phagosome | 34/867 | 152/8465 | 8.00e-06 | 9.99e-05 | 7.48e-05 | 34 |
hsa0541633 | Breast | IDC | Viral myocarditis | 18/867 | 60/8465 | 1.85e-05 | 2.01e-04 | 1.50e-04 | 18 |
hsa0516634 | Breast | IDC | Human T-cell leukemia virus 1 infection | 40/867 | 222/8465 | 2.52e-04 | 2.21e-03 | 1.66e-03 | 40 |
hsa0532331 | Breast | IDC | Rheumatoid arthritis | 21/867 | 93/8465 | 3.69e-04 | 3.15e-03 | 2.36e-03 | 21 |
hsa0494015 | Breast | IDC | Type I diabetes mellitus | 12/867 | 43/8465 | 9.40e-04 | 7.28e-03 | 5.44e-03 | 12 |
hsa0533013 | Breast | IDC | Allograft rejection | 11/867 | 38/8465 | 1.09e-03 | 8.26e-03 | 6.18e-03 | 11 |
hsa0533211 | Breast | IDC | Graft-versus-host disease | 11/867 | 42/8465 | 2.66e-03 | 1.80e-02 | 1.35e-02 | 11 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Breast | DCIS |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Breast | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Breast | IDC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | CC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Cervix | Precancer |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | AD |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | MSI-H |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | MSS |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | CRC | SER |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | AEH |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | EEC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | Endometrium | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | ADJ |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | Healthy |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | OSCC |
HLA-DPA1 | CD4 | HLA-DPA1_CD4 | MHC-II | HNSCC | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HLA-DPA1 | SNV | Missense_Mutation | c.397C>T | p.Pro133Ser | p.P133S | P20036 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
HLA-DPA1 | SNV | Missense_Mutation | novel | c.325N>G | p.Asn109Asp | p.N109D | P20036 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | rs770307009 | c.746N>A | p.Arg249His | p.R249H | P20036 | protein_coding | tolerated(0.21) | benign(0.005) | TCGA-CM-4747-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | fluorouracil | SD |
HLA-DPA1 | SNV | Missense_Mutation | rs371532700 | c.137C>T | p.Thr46Met | p.T46M | P20036 | protein_coding | deleterious(0.04) | possibly_damaging(0.895) | TCGA-G4-6295-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | c.100N>A | p.Ala34Thr | p.A34T | P20036 | protein_coding | deleterious(0.03) | benign(0.106) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
HLA-DPA1 | SNV | Missense_Mutation | c.484G>T | p.Gly162Cys | p.G162C | P20036 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HLA-DPA1 | SNV | Missense_Mutation | rs751649425 | c.724N>A | p.Val242Ile | p.V242I | P20036 | protein_coding | tolerated(1) | benign(0) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | novel | c.446N>G | p.Asn149Ser | p.N149S | P20036 | protein_coding | tolerated(0.18) | benign(0.033) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | rs761093053 | c.5N>A | p.Arg2His | p.R2H | P20036 | protein_coding | tolerated_low_confidence(0.56) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HLA-DPA1 | SNV | Missense_Mutation | novel | c.718G>A | p.Gly240Ser | p.G240S | P20036 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3113 | HLA-DPA1 | CLINICALLY ACTIONABLE, DRUGGABLE GENOME, CELL SURFACE | peginterferon alfa-2b | 26387494 |
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