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Gene: HIGD2A |
Gene summary for HIGD2A |
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Gene information | Species | Human | Gene symbol | HIGD2A | Gene ID | 192286 |
Gene name | HIG1 hypoxia inducible domain family member 2A | |
Gene Alias | RCF1b | |
Cytomap | 5q35.2 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | A0A024R7Q3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
192286 | HIGD2A | P5T-E | Human | Esophagus | ESCC | 2.00e-46 | 1.25e+00 | 0.1327 |
192286 | HIGD2A | P8T-E | Human | Esophagus | ESCC | 6.98e-21 | 7.52e-01 | 0.0889 |
192286 | HIGD2A | P9T-E | Human | Esophagus | ESCC | 3.27e-26 | 9.56e-01 | 0.1131 |
192286 | HIGD2A | P10T-E | Human | Esophagus | ESCC | 1.97e-31 | 8.87e-01 | 0.116 |
192286 | HIGD2A | P11T-E | Human | Esophagus | ESCC | 1.62e-22 | 1.43e+00 | 0.1426 |
192286 | HIGD2A | P12T-E | Human | Esophagus | ESCC | 1.32e-54 | 1.58e+00 | 0.1122 |
192286 | HIGD2A | P15T-E | Human | Esophagus | ESCC | 1.08e-54 | 1.84e+00 | 0.1149 |
192286 | HIGD2A | P16T-E | Human | Esophagus | ESCC | 1.95e-27 | 7.44e-01 | 0.1153 |
192286 | HIGD2A | P17T-E | Human | Esophagus | ESCC | 3.54e-20 | 1.44e+00 | 0.1278 |
192286 | HIGD2A | P19T-E | Human | Esophagus | ESCC | 1.29e-10 | 1.51e+00 | 0.1662 |
192286 | HIGD2A | P20T-E | Human | Esophagus | ESCC | 6.98e-38 | 1.30e+00 | 0.1124 |
192286 | HIGD2A | P21T-E | Human | Esophagus | ESCC | 4.53e-86 | 1.96e+00 | 0.1617 |
192286 | HIGD2A | P22T-E | Human | Esophagus | ESCC | 3.13e-94 | 2.09e+00 | 0.1236 |
192286 | HIGD2A | P23T-E | Human | Esophagus | ESCC | 2.37e-52 | 1.86e+00 | 0.108 |
192286 | HIGD2A | P24T-E | Human | Esophagus | ESCC | 6.50e-31 | 1.07e+00 | 0.1287 |
192286 | HIGD2A | P26T-E | Human | Esophagus | ESCC | 3.23e-75 | 1.70e+00 | 0.1276 |
192286 | HIGD2A | P27T-E | Human | Esophagus | ESCC | 1.20e-45 | 1.30e+00 | 0.1055 |
192286 | HIGD2A | P28T-E | Human | Esophagus | ESCC | 2.01e-58 | 1.58e+00 | 0.1149 |
192286 | HIGD2A | P30T-E | Human | Esophagus | ESCC | 4.52e-50 | 2.18e+00 | 0.137 |
192286 | HIGD2A | P31T-E | Human | Esophagus | ESCC | 8.64e-50 | 1.08e+00 | 0.1251 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0097250 | Stomach | GC | mitochondrial respirasome assembly | 4/1159 | 10/18723 | 2.27e-03 | 2.20e-02 | 4 |
GO:00972501 | Stomach | CAG with IM | mitochondrial respirasome assembly | 4/1050 | 10/18723 | 1.57e-03 | 1.75e-02 | 4 |
GO:00972502 | Stomach | CSG | mitochondrial respirasome assembly | 4/1034 | 10/18723 | 1.48e-03 | 1.68e-02 | 4 |
GO:00972503 | Stomach | CAG | mitochondrial respirasome assembly | 3/552 | 10/18723 | 2.62e-03 | 2.71e-02 | 3 |
GO:00972504 | Stomach | SIM | mitochondrial respirasome assembly | 3/708 | 10/18723 | 5.29e-03 | 4.41e-02 | 3 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIGD2A | SNV | Missense_Mutation | novel | c.68G>C | p.Gly23Ala | p.G23A | Q9BW72 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
HIGD2A | SNV | Missense_Mutation | c.226N>G | p.Gln76Glu | p.Q76E | Q9BW72 | protein_coding | deleterious(0) | possibly_damaging(0.685) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HIGD2A | SNV | Missense_Mutation | c.262T>C | p.Phe88Leu | p.F88L | Q9BW72 | protein_coding | tolerated(0.1) | probably_damaging(0.975) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HIGD2A | SNV | Missense_Mutation | c.247A>G | p.Ile83Val | p.I83V | Q9BW72 | protein_coding | tolerated(0.41) | possibly_damaging(0.497) | TCGA-D5-6535-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HIGD2A | SNV | Missense_Mutation | novel | c.209N>A | p.Gly70Asp | p.G70D | Q9BW72 | protein_coding | tolerated(0.05) | possibly_damaging(0.878) | TCGA-AJ-A23O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIGD2A | SNV | Missense_Mutation | c.103T>G | p.Phe35Val | p.F35V | Q9BW72 | protein_coding | tolerated(0.08) | benign(0.189) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HIGD2A | SNV | Missense_Mutation | novel | c.105N>A | p.Phe35Leu | p.F35L | Q9BW72 | protein_coding | tolerated(0.1) | possibly_damaging(0.526) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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