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Gene: HIGD1A |
Gene summary for HIGD1A |
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Gene information | Species | Human | Gene symbol | HIGD1A | Gene ID | 25994 |
Gene name | HIG1 hypoxia inducible domain family member 1A | |
Gene Alias | HIG1 | |
Cytomap | 3p22.1 | |
Gene Type | protein-coding | GO ID | GO:0006915 | UniProtAcc | Q9Y241 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25994 | HIGD1A | HCC2 | Human | Liver | HCC | 4.53e-19 | 4.25e+00 | 0.5341 |
25994 | HIGD1A | HCC5 | Human | Liver | HCC | 2.25e-02 | 1.19e+00 | 0.4932 |
25994 | HIGD1A | Pt13.a | Human | Liver | HCC | 3.80e-02 | 5.55e-02 | 0.021 |
25994 | HIGD1A | Pt13.b | Human | Liver | HCC | 7.50e-25 | 1.76e-01 | 0.0251 |
25994 | HIGD1A | Pt14.a | Human | Liver | HCC | 7.33e-04 | 1.20e-01 | 0.0169 |
25994 | HIGD1A | Pt14.b | Human | Liver | HCC | 4.28e-09 | 1.94e-01 | 0.018 |
25994 | HIGD1A | Pt14.d | Human | Liver | HCC | 6.64e-03 | 4.88e-03 | 0.0143 |
25994 | HIGD1A | S028 | Human | Liver | HCC | 4.76e-05 | 7.43e-01 | 0.2503 |
25994 | HIGD1A | S029 | Human | Liver | HCC | 1.29e-16 | 1.39e+00 | 0.2581 |
25994 | HIGD1A | C04 | Human | Oral cavity | OSCC | 6.46e-27 | 1.36e+00 | 0.2633 |
25994 | HIGD1A | C21 | Human | Oral cavity | OSCC | 1.73e-30 | 1.19e+00 | 0.2678 |
25994 | HIGD1A | C30 | Human | Oral cavity | OSCC | 7.52e-43 | 2.06e+00 | 0.3055 |
25994 | HIGD1A | C38 | Human | Oral cavity | OSCC | 3.03e-13 | 1.11e+00 | 0.172 |
25994 | HIGD1A | C43 | Human | Oral cavity | OSCC | 2.01e-15 | 4.27e-01 | 0.1704 |
25994 | HIGD1A | C46 | Human | Oral cavity | OSCC | 4.27e-30 | 8.67e-01 | 0.1673 |
25994 | HIGD1A | C51 | Human | Oral cavity | OSCC | 1.48e-09 | 6.19e-01 | 0.2674 |
25994 | HIGD1A | C57 | Human | Oral cavity | OSCC | 4.37e-27 | 1.09e+00 | 0.1679 |
25994 | HIGD1A | C06 | Human | Oral cavity | OSCC | 2.86e-07 | 1.38e+00 | 0.2699 |
25994 | HIGD1A | C08 | Human | Oral cavity | OSCC | 2.49e-18 | 6.57e-01 | 0.1919 |
25994 | HIGD1A | C09 | Human | Oral cavity | OSCC | 1.00e-21 | 9.28e-01 | 0.1431 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIGD1A | SNV | Missense_Mutation | novel | c.79G>C | p.Glu27Gln | p.E27Q | Q9Y241 | protein_coding | deleterious(0.03) | possibly_damaging(0.521) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
HIGD1A | SNV | Missense_Mutation | rs561542879 | c.146N>T | p.Ala49Val | p.A49V | Q9Y241 | protein_coding | deleterious(0.01) | possibly_damaging(0.666) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIGD1A | SNV | Missense_Mutation | rs745348917 | c.271N>T | p.Val91Phe | p.V91F | Q9Y241 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-A5-A0GR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HIGD1A | SNV | Missense_Mutation | novel | c.303C>A | p.Phe101Leu | p.F101L | Q9Y241 | protein_coding | tolerated(0.08) | possibly_damaging(0.611) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
HIGD1A | SNV | Missense_Mutation | novel | c.267G>A | p.Met89Ile | p.M89I | Q9Y241 | protein_coding | tolerated(0.45) | benign(0.03) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HIGD1A | SNV | Missense_Mutation | c.296N>A | p.Arg99Gln | p.R99Q | Q9Y241 | protein_coding | tolerated(0.49) | benign(0.003) | TCGA-B5-A11N-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIGD1A | SNV | Missense_Mutation | c.192C>A | p.Ser64Arg | p.S64R | Q9Y241 | protein_coding | tolerated(0.14) | benign(0.099) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIGD1A | SNV | Missense_Mutation | rs368330989 | c.277N>G | p.Met93Val | p.M93V | Q9Y241 | protein_coding | tolerated(1) | benign(0.009) | TCGA-K7-A6G5-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HIGD1A | SNV | Missense_Mutation | novel | c.134N>T | p.Pro45Leu | p.P45L | Q9Y241 | protein_coding | tolerated(0.06) | probably_damaging(0.984) | TCGA-L4-A4E5-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIGD1A | SNV | Missense_Mutation | c.172N>A | p.Gly58Arg | p.G58R | Q9Y241 | protein_coding | tolerated(0.2) | possibly_damaging(0.767) | TCGA-21-1077-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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