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Gene: GTPBP4 |
Gene summary for GTPBP4 |
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Gene information | Species | Human | Gene symbol | GTPBP4 | Gene ID | 23560 |
Gene name | GTP binding protein 4 | |
Gene Alias | CRFG | |
Cytomap | 10p15.3 | |
Gene Type | protein-coding | GO ID | GO:0000079 | UniProtAcc | D2CFK9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23560 | GTPBP4 | S016 | Human | Liver | HCC | 1.13e-46 | 1.43e+00 | 0.2243 |
23560 | GTPBP4 | S027 | Human | Liver | HCC | 7.30e-08 | 7.75e-01 | 0.2446 |
23560 | GTPBP4 | S028 | Human | Liver | HCC | 1.36e-23 | 1.16e+00 | 0.2503 |
23560 | GTPBP4 | S029 | Human | Liver | HCC | 1.40e-20 | 1.13e+00 | 0.2581 |
23560 | GTPBP4 | C04 | Human | Oral cavity | OSCC | 1.27e-11 | 9.46e-01 | 0.2633 |
23560 | GTPBP4 | C21 | Human | Oral cavity | OSCC | 1.63e-21 | 1.00e+00 | 0.2678 |
23560 | GTPBP4 | C30 | Human | Oral cavity | OSCC | 3.27e-25 | 1.63e+00 | 0.3055 |
23560 | GTPBP4 | C38 | Human | Oral cavity | OSCC | 3.20e-09 | 1.37e+00 | 0.172 |
23560 | GTPBP4 | C43 | Human | Oral cavity | OSCC | 2.22e-20 | 4.53e-01 | 0.1704 |
23560 | GTPBP4 | C46 | Human | Oral cavity | OSCC | 1.26e-12 | 4.74e-01 | 0.1673 |
23560 | GTPBP4 | C51 | Human | Oral cavity | OSCC | 1.67e-02 | 4.66e-01 | 0.2674 |
23560 | GTPBP4 | C57 | Human | Oral cavity | OSCC | 5.67e-05 | 5.01e-01 | 0.1679 |
23560 | GTPBP4 | C06 | Human | Oral cavity | OSCC | 7.78e-13 | 2.57e+00 | 0.2699 |
23560 | GTPBP4 | C08 | Human | Oral cavity | OSCC | 7.73e-14 | 4.68e-01 | 0.1919 |
23560 | GTPBP4 | LN22 | Human | Oral cavity | OSCC | 6.15e-05 | 7.85e-01 | 0.1733 |
23560 | GTPBP4 | LN38 | Human | Oral cavity | OSCC | 3.67e-03 | 1.04e+00 | 0.168 |
23560 | GTPBP4 | LN46 | Human | Oral cavity | OSCC | 1.33e-05 | 5.23e-01 | 0.1666 |
23560 | GTPBP4 | LP15 | Human | Oral cavity | LP | 4.66e-03 | 1.15e+00 | 0.2174 |
23560 | GTPBP4 | SYSMH1 | Human | Oral cavity | OSCC | 4.63e-11 | 4.28e-01 | 0.1127 |
23560 | GTPBP4 | SYSMH2 | Human | Oral cavity | OSCC | 4.14e-20 | 8.79e-01 | 0.2326 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261316 | Endometrium | AEH | ribonucleoprotein complex biogenesis | 107/2100 | 463/18723 | 1.43e-13 | 4.08e-11 | 107 |
GO:190332016 | Endometrium | AEH | regulation of protein modification by small protein conjugation or removal | 67/2100 | 242/18723 | 1.10e-12 | 2.26e-10 | 67 |
GO:003164716 | Endometrium | AEH | regulation of protein stability | 77/2100 | 298/18723 | 1.13e-12 | 2.26e-10 | 77 |
GO:005082116 | Endometrium | AEH | protein stabilization | 55/2100 | 191/18723 | 2.19e-11 | 3.20e-09 | 55 |
GO:004227316 | Endometrium | AEH | ribosomal large subunit biogenesis | 30/2100 | 72/18723 | 3.69e-11 | 5.03e-09 | 30 |
GO:003139616 | Endometrium | AEH | regulation of protein ubiquitination | 57/2100 | 210/18723 | 1.24e-10 | 1.40e-08 | 57 |
GO:004225416 | Endometrium | AEH | ribosome biogenesis | 67/2100 | 299/18723 | 1.95e-08 | 1.18e-06 | 67 |
GO:005109816 | Endometrium | AEH | regulation of binding | 77/2100 | 363/18723 | 2.21e-08 | 1.31e-06 | 77 |
GO:003139716 | Endometrium | AEH | negative regulation of protein ubiquitination | 28/2100 | 83/18723 | 4.36e-08 | 2.40e-06 | 28 |
GO:190332116 | Endometrium | AEH | negative regulation of protein modification by small protein conjugation or removal | 30/2100 | 95/18723 | 7.94e-08 | 4.04e-06 | 30 |
GO:00016498 | Endometrium | AEH | osteoblast differentiation | 52/2100 | 229/18723 | 4.74e-07 | 1.92e-05 | 52 |
GO:00015038 | Endometrium | AEH | ossification | 78/2100 | 408/18723 | 1.54e-06 | 4.85e-05 | 78 |
GO:00303364 | Endometrium | AEH | negative regulation of cell migration | 65/2100 | 344/18723 | 1.65e-05 | 3.42e-04 | 65 |
GO:00063648 | Endometrium | AEH | rRNA processing | 47/2100 | 225/18723 | 1.78e-05 | 3.65e-04 | 47 |
GO:20001464 | Endometrium | AEH | negative regulation of cell motility | 67/2100 | 359/18723 | 1.86e-05 | 3.77e-04 | 67 |
GO:00512714 | Endometrium | AEH | negative regulation of cellular component movement | 68/2100 | 367/18723 | 2.06e-05 | 4.11e-04 | 68 |
GO:00004704 | Endometrium | AEH | maturation of LSU-rRNA | 12/2100 | 28/18723 | 2.08e-05 | 4.13e-04 | 12 |
GO:002240714 | Endometrium | AEH | regulation of cell-cell adhesion | 79/2100 | 448/18723 | 2.90e-05 | 5.40e-04 | 79 |
GO:00160728 | Endometrium | AEH | rRNA metabolic process | 48/2100 | 236/18723 | 3.01e-05 | 5.54e-04 | 48 |
GO:00400134 | Endometrium | AEH | negative regulation of locomotion | 70/2100 | 391/18723 | 4.95e-05 | 8.05e-04 | 70 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP4 | SNV | Missense_Mutation | novel | c.87N>T | p.Lys29Asn | p.K29N | Q9BZE4 | protein_coding | deleterious(0) | possibly_damaging(0.677) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GTPBP4 | SNV | Missense_Mutation | novel | c.328N>T | p.Ala110Ser | p.A110S | Q9BZE4 | protein_coding | tolerated(0.45) | benign(0.057) | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP4 | SNV | Missense_Mutation | c.49G>T | p.Asp17Tyr | p.D17Y | Q9BZE4 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-E2-A15A-06 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
GTPBP4 | insertion | Frame_Shift_Ins | novel | c.1514_1515insGCCTGGCCCCCGTCTC | p.Arg507GlyfsTer12 | p.R507Gfs*12 | Q9BZE4 | protein_coding | TCGA-BH-A0H6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GTPBP4 | SNV | Missense_Mutation | rs773394843 | c.1697G>A | p.Arg566Gln | p.R566Q | Q9BZE4 | protein_coding | deleterious(0.03) | benign(0.217) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
GTPBP4 | SNV | Missense_Mutation | novel | c.168N>T | p.Gln56His | p.Q56H | Q9BZE4 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GTPBP4 | SNV | Missense_Mutation | rs774844408 | c.83N>A | p.Arg28Gln | p.R28Q | Q9BZE4 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GTPBP4 | SNV | Missense_Mutation | c.262G>A | p.Asp88Asn | p.D88N | Q9BZE4 | protein_coding | tolerated(0.13) | possibly_damaging(0.873) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GTPBP4 | SNV | Missense_Mutation | rs372753265 | c.1529N>A | p.Arg510Gln | p.R510Q | Q9BZE4 | protein_coding | deleterious(0.01) | benign(0.426) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTPBP4 | SNV | Missense_Mutation | c.1606N>A | p.Asp536Asn | p.D536N | Q9BZE4 | protein_coding | tolerated(0.32) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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