Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/GRINA_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/GRINA_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/GRINA_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/GRINA_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GRINA_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/GRINA_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/GRINA_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/GRINA_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/GRINA_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123314 | Breast | IDC | regulation of apoptotic signaling pathway | 82/1434 | 356/18723 | 6.27e-20 | 5.93e-17 | 82 |
GO:009719314 | Breast | IDC | intrinsic apoptotic signaling pathway | 69/1434 | 288/18723 | 6.32e-18 | 2.99e-15 | 69 |
GO:200124214 | Breast | IDC | regulation of intrinsic apoptotic signaling pathway | 47/1434 | 164/18723 | 8.25e-16 | 2.93e-13 | 47 |
GO:200123414 | Breast | IDC | negative regulation of apoptotic signaling pathway | 49/1434 | 224/18723 | 1.45e-11 | 2.58e-09 | 49 |
GO:200124314 | Breast | IDC | negative regulation of intrinsic apoptotic signaling pathway | 27/1434 | 98/18723 | 2.91e-09 | 2.50e-07 | 27 |
GO:003497614 | Breast | IDC | response to endoplasmic reticulum stress | 43/1434 | 256/18723 | 8.42e-07 | 3.82e-05 | 43 |
GO:190589714 | Breast | IDC | regulation of response to endoplasmic reticulum stress | 19/1434 | 82/18723 | 1.04e-05 | 2.87e-04 | 19 |
GO:190357313 | Breast | IDC | negative regulation of response to endoplasmic reticulum stress | 13/1434 | 44/18723 | 1.62e-05 | 4.05e-04 | 13 |
GO:007005914 | Breast | IDC | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | 14/1434 | 63/18723 | 2.37e-04 | 3.75e-03 | 14 |
GO:003246913 | Breast | IDC | endoplasmic reticulum calcium ion homeostasis | 8/1434 | 25/18723 | 3.85e-04 | 5.40e-03 | 8 |
GO:190223614 | Breast | IDC | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 7/1434 | 20/18723 | 4.85e-04 | 6.42e-03 | 7 |
GO:19022355 | Breast | IDC | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | 8/1434 | 32/18723 | 2.32e-03 | 2.10e-02 | 8 |
GO:200123324 | Breast | DCIS | regulation of apoptotic signaling pathway | 81/1390 | 356/18723 | 3.51e-20 | 3.31e-17 | 81 |
GO:009719324 | Breast | DCIS | intrinsic apoptotic signaling pathway | 68/1390 | 288/18723 | 4.93e-18 | 2.33e-15 | 68 |
GO:200124224 | Breast | DCIS | regulation of intrinsic apoptotic signaling pathway | 47/1390 | 164/18723 | 2.49e-16 | 9.38e-14 | 47 |
GO:200123424 | Breast | DCIS | negative regulation of apoptotic signaling pathway | 48/1390 | 224/18723 | 1.70e-11 | 3.22e-09 | 48 |
GO:200124322 | Breast | DCIS | negative regulation of intrinsic apoptotic signaling pathway | 27/1390 | 98/18723 | 1.48e-09 | 1.42e-07 | 27 |
GO:003497622 | Breast | DCIS | response to endoplasmic reticulum stress | 43/1390 | 256/18723 | 3.65e-07 | 1.71e-05 | 43 |
GO:190589722 | Breast | DCIS | regulation of response to endoplasmic reticulum stress | 19/1390 | 82/18723 | 6.65e-06 | 1.86e-04 | 19 |
GO:190357322 | Breast | DCIS | negative regulation of response to endoplasmic reticulum stress | 13/1390 | 44/18723 | 1.16e-05 | 2.98e-04 | 13 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRINA | SNV | Missense_Mutation | | c.658T>G | p.Phe220Val | p.F220V | Q7Z429 | protein_coding | tolerated(0.29) | benign(0.031) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
GRINA | insertion | Frame_Shift_Ins | novel | c.17_18insT | p.Leu8PhefsTer119 | p.L8Ffs*119 | Q7Z429 | protein_coding | | | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GRINA | SNV | Missense_Mutation | rs560551768 | c.73C>G | p.Pro25Ala | p.P25A | Q7Z429 | protein_coding | deleterious(0.05) | benign(0.098) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRINA | SNV | Missense_Mutation | | c.302A>G | p.Gln101Arg | p.Q101R | Q7Z429 | protein_coding | tolerated(0.26) | possibly_damaging(0.901) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRINA | SNV | Missense_Mutation | rs782307051 | c.487N>T | p.Arg163Cys | p.R163C | Q7Z429 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
GRINA | SNV | Missense_Mutation | rs200050797 | c.560N>T | p.Ala187Val | p.A187V | Q7Z429 | protein_coding | tolerated(0.06) | benign(0.327) | TCGA-AX-A1C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRINA | SNV | Missense_Mutation | rs560551768 | c.73C>G | p.Pro25Ala | p.P25A | Q7Z429 | protein_coding | deleterious(0.05) | benign(0.098) | TCGA-B5-A0JU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRINA | SNV | Missense_Mutation | novel | c.488G>A | p.Arg163His | p.R163H | Q7Z429 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRINA | SNV | Missense_Mutation | rs560551768 | c.73C>G | p.Pro25Ala | p.P25A | Q7Z429 | protein_coding | deleterious(0.05) | benign(0.098) | TCGA-EO-A3KX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRINA | SNV | Missense_Mutation | novel | c.15N>T | p.Lys5Asn | p.K5N | Q7Z429 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.505) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |