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Gene: GRHPR |
Gene summary for GRHPR |
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Gene information | Species | Human | Gene symbol | GRHPR | Gene ID | 9380 |
Gene name | glyoxylate and hydroxypyruvate reductase | |
Gene Alias | GLXR | |
Cytomap | 9p13.2 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q9UBQ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9380 | GRHPR | P76T-E | Human | Esophagus | ESCC | 1.42e-50 | 1.01e+00 | 0.1207 |
9380 | GRHPR | P79T-E | Human | Esophagus | ESCC | 7.60e-29 | 6.70e-01 | 0.1154 |
9380 | GRHPR | P80T-E | Human | Esophagus | ESCC | 1.28e-31 | 1.11e+00 | 0.155 |
9380 | GRHPR | P82T-E | Human | Esophagus | ESCC | 2.74e-25 | 1.45e+00 | 0.1072 |
9380 | GRHPR | P83T-E | Human | Esophagus | ESCC | 1.21e-60 | 1.73e+00 | 0.1738 |
9380 | GRHPR | P84T-E | Human | Esophagus | ESCC | 1.32e-12 | 8.55e-01 | 0.0933 |
9380 | GRHPR | P89T-E | Human | Esophagus | ESCC | 1.16e-25 | 1.89e+00 | 0.1752 |
9380 | GRHPR | P91T-E | Human | Esophagus | ESCC | 7.89e-20 | 2.12e+00 | 0.1828 |
9380 | GRHPR | P104T-E | Human | Esophagus | ESCC | 7.27e-04 | 6.26e-01 | 0.0931 |
9380 | GRHPR | P107T-E | Human | Esophagus | ESCC | 2.81e-56 | 1.27e+00 | 0.171 |
9380 | GRHPR | P126T-E | Human | Esophagus | ESCC | 5.75e-05 | 6.89e-01 | 0.1125 |
9380 | GRHPR | P127T-E | Human | Esophagus | ESCC | 1.41e-22 | 3.67e-01 | 0.0826 |
9380 | GRHPR | P128T-E | Human | Esophagus | ESCC | 1.64e-38 | 1.18e+00 | 0.1241 |
9380 | GRHPR | P130T-E | Human | Esophagus | ESCC | 1.15e-58 | 1.14e+00 | 0.1676 |
9380 | GRHPR | S43 | Human | Liver | Cirrhotic | 4.01e-08 | -2.45e-01 | -0.0187 |
9380 | GRHPR | HCC1_Meng | Human | Liver | HCC | 1.97e-68 | 2.54e-01 | 0.0246 |
9380 | GRHPR | HCC2_Meng | Human | Liver | HCC | 3.66e-20 | -1.63e-01 | 0.0107 |
9380 | GRHPR | cirrhotic1 | Human | Liver | Cirrhotic | 6.01e-09 | 1.76e-01 | 0.0202 |
9380 | GRHPR | cirrhotic2 | Human | Liver | Cirrhotic | 9.74e-16 | 2.07e-01 | 0.0201 |
9380 | GRHPR | cirrhotic3 | Human | Liver | Cirrhotic | 3.89e-11 | 3.40e-01 | 0.0215 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043648 | Colorectum | AD | dicarboxylic acid metabolic process | 34/3918 | 96/18723 | 7.22e-04 | 7.28e-03 | 34 |
GO:0006081 | Colorectum | AD | cellular aldehyde metabolic process | 22/3918 | 60/18723 | 3.64e-03 | 2.60e-02 | 22 |
GO:00060811 | Colorectum | MSS | cellular aldehyde metabolic process | 21/3467 | 60/18723 | 1.81e-03 | 1.60e-02 | 21 |
GO:00060812 | Colorectum | MSI-H | cellular aldehyde metabolic process | 13/1319 | 60/18723 | 2.27e-04 | 5.94e-03 | 13 |
GO:00060818 | Esophagus | ESCC | cellular aldehyde metabolic process | 40/8552 | 60/18723 | 8.30e-04 | 4.28e-03 | 40 |
GO:00436485 | Esophagus | ESCC | dicarboxylic acid metabolic process | 58/8552 | 96/18723 | 2.55e-03 | 1.09e-02 | 58 |
GO:004364811 | Liver | Cirrhotic | dicarboxylic acid metabolic process | 43/4634 | 96/18723 | 1.42e-05 | 1.97e-04 | 43 |
GO:00060815 | Liver | Cirrhotic | cellular aldehyde metabolic process | 28/4634 | 60/18723 | 1.83e-04 | 1.71e-03 | 28 |
GO:00436482 | Liver | HCC | dicarboxylic acid metabolic process | 68/7958 | 96/18723 | 1.73e-08 | 4.14e-07 | 68 |
GO:000608112 | Liver | HCC | cellular aldehyde metabolic process | 39/7958 | 60/18723 | 3.61e-04 | 2.50e-03 | 39 |
GO:00060817 | Oral cavity | OSCC | cellular aldehyde metabolic process | 36/7305 | 60/18723 | 7.94e-04 | 4.27e-03 | 36 |
GO:00436484 | Oral cavity | OSCC | dicarboxylic acid metabolic process | 50/7305 | 96/18723 | 6.24e-03 | 2.35e-02 | 50 |
GO:000608114 | Oral cavity | LP | cellular aldehyde metabolic process | 26/4623 | 60/18723 | 1.19e-03 | 9.62e-03 | 26 |
GO:00060816 | Prostate | BPH | cellular aldehyde metabolic process | 20/3107 | 60/18723 | 1.14e-03 | 7.10e-03 | 20 |
GO:000608113 | Prostate | Tumor | cellular aldehyde metabolic process | 21/3246 | 60/18723 | 7.59e-04 | 5.20e-03 | 21 |
GO:00060819 | Skin | cSCC | cellular aldehyde metabolic process | 28/4864 | 60/18723 | 4.35e-04 | 3.36e-03 | 28 |
GO:00436486 | Skin | cSCC | dicarboxylic acid metabolic process | 38/4864 | 96/18723 | 2.38e-03 | 1.38e-02 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa00630 | Colorectum | AD | Glyoxylate and dicarboxylate metabolism | 14/2092 | 30/8465 | 7.25e-03 | 2.97e-02 | 1.89e-02 | 14 |
hsa006301 | Colorectum | AD | Glyoxylate and dicarboxylate metabolism | 14/2092 | 30/8465 | 7.25e-03 | 2.97e-02 | 1.89e-02 | 14 |
hsa006202 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa006203 | Colorectum | SER | Pyruvate metabolism | 22/1580 | 47/8465 | 9.62e-06 | 1.33e-04 | 9.67e-05 | 22 |
hsa006204 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa006205 | Colorectum | MSS | Pyruvate metabolism | 24/1875 | 47/8465 | 1.25e-05 | 1.35e-04 | 8.27e-05 | 24 |
hsa006302 | Colorectum | MSI-H | Glyoxylate and dicarboxylate metabolism | 8/797 | 30/8465 | 5.34e-03 | 4.94e-02 | 4.14e-02 | 8 |
hsa006303 | Colorectum | MSI-H | Glyoxylate and dicarboxylate metabolism | 8/797 | 30/8465 | 5.34e-03 | 4.94e-02 | 4.14e-02 | 8 |
hsa0062023 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa006306 | Esophagus | ESCC | Glyoxylate and dicarboxylate metabolism | 21/4205 | 30/8465 | 1.95e-02 | 4.35e-02 | 2.23e-02 | 21 |
hsa0062033 | Esophagus | ESCC | Pyruvate metabolism | 32/4205 | 47/8465 | 8.11e-03 | 1.94e-02 | 9.94e-03 | 32 |
hsa0063013 | Esophagus | ESCC | Glyoxylate and dicarboxylate metabolism | 21/4205 | 30/8465 | 1.95e-02 | 4.35e-02 | 2.23e-02 | 21 |
hsa006208 | Liver | Cirrhotic | Pyruvate metabolism | 29/2530 | 47/8465 | 5.90e-06 | 5.95e-05 | 3.67e-05 | 29 |
hsa006304 | Liver | Cirrhotic | Glyoxylate and dicarboxylate metabolism | 20/2530 | 30/8465 | 3.36e-05 | 2.54e-04 | 1.57e-04 | 20 |
hsa00260 | Liver | Cirrhotic | Glycine, serine and threonine metabolism | 22/2530 | 40/8465 | 7.85e-04 | 4.51e-03 | 2.78e-03 | 22 |
hsa0062011 | Liver | Cirrhotic | Pyruvate metabolism | 29/2530 | 47/8465 | 5.90e-06 | 5.95e-05 | 3.67e-05 | 29 |
hsa0063011 | Liver | Cirrhotic | Glyoxylate and dicarboxylate metabolism | 20/2530 | 30/8465 | 3.36e-05 | 2.54e-04 | 1.57e-04 | 20 |
hsa002601 | Liver | Cirrhotic | Glycine, serine and threonine metabolism | 22/2530 | 40/8465 | 7.85e-04 | 4.51e-03 | 2.78e-03 | 22 |
hsa0062021 | Liver | HCC | Pyruvate metabolism | 37/4020 | 47/8465 | 1.10e-05 | 8.03e-05 | 4.46e-05 | 37 |
hsa0063021 | Liver | HCC | Glyoxylate and dicarboxylate metabolism | 24/4020 | 30/8465 | 2.66e-04 | 1.24e-03 | 6.88e-04 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRHPR | SNV | Missense_Mutation | c.73N>T | p.Arg25Trp | p.R25W | Q9UBQ7 | protein_coding | deleterious(0) | benign(0.357) | TCGA-E9-A1RH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
GRHPR | SNV | Missense_Mutation | novel | c.508C>T | p.Arg170Trp | p.R170W | Q9UBQ7 | protein_coding | deleterious(0) | possibly_damaging(0.848) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
GRHPR | SNV | Missense_Mutation | rs566239341 | c.419N>T | p.Ser140Leu | p.S140L | Q9UBQ7 | protein_coding | tolerated(0.08) | benign(0.131) | TCGA-DG-A2KL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
GRHPR | SNV | Missense_Mutation | c.241A>G | p.Met81Val | p.M81V | Q9UBQ7 | protein_coding | tolerated(0.07) | benign(0.039) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GRHPR | SNV | Missense_Mutation | rs146603229 | c.296N>A | p.Arg99Gln | p.R99Q | Q9UBQ7 | protein_coding | tolerated(0.12) | benign(0.152) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
GRHPR | SNV | Missense_Mutation | novel | c.964A>T | p.Met322Leu | p.M322L | Q9UBQ7 | protein_coding | tolerated(0.19) | benign(0.245) | TCGA-G4-6303-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
GRHPR | SNV | Missense_Mutation | c.739G>T | p.Asp247Tyr | p.D247Y | Q9UBQ7 | protein_coding | deleterious(0) | possibly_damaging(0.767) | TCGA-AG-3887-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | irinotecan | SD | |
GRHPR | SNV | Missense_Mutation | rs180177312 | c.478N>A | p.Gly160Arg | p.G160R | Q9UBQ7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRHPR | SNV | Missense_Mutation | novel | c.415N>G | p.Thr139Ala | p.T139A | Q9UBQ7 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GRHPR | SNV | Missense_Mutation | rs369950120 | c.742N>A | p.Val248Ile | p.V248I | Q9UBQ7 | protein_coding | tolerated(0.09) | benign(0.198) | TCGA-AP-A0LT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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