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Gene: GLTP |
Gene summary for GLTP |
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Gene information | Species | Human | Gene symbol | GLTP | Gene ID | 51228 |
Gene name | glycolipid transfer protein | |
Gene Alias | GLTP | |
Cytomap | 12q24.11 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | A0A024RBI7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51228 | GLTP | P83T-E | Human | Esophagus | ESCC | 5.19e-29 | 1.12e+00 | 0.1738 |
51228 | GLTP | P84T-E | Human | Esophagus | ESCC | 1.03e-09 | 8.77e-01 | 0.0933 |
51228 | GLTP | P89T-E | Human | Esophagus | ESCC | 6.59e-14 | 1.48e+00 | 0.1752 |
51228 | GLTP | P91T-E | Human | Esophagus | ESCC | 4.20e-07 | 1.34e+00 | 0.1828 |
51228 | GLTP | P107T-E | Human | Esophagus | ESCC | 2.01e-26 | 9.13e-01 | 0.171 |
51228 | GLTP | P126T-E | Human | Esophagus | ESCC | 2.96e-09 | 1.24e+00 | 0.1125 |
51228 | GLTP | P127T-E | Human | Esophagus | ESCC | 1.11e-46 | 9.85e-01 | 0.0826 |
51228 | GLTP | P128T-E | Human | Esophagus | ESCC | 6.97e-20 | 9.83e-01 | 0.1241 |
51228 | GLTP | P130T-E | Human | Esophagus | ESCC | 1.08e-59 | 1.61e+00 | 0.1676 |
51228 | GLTP | HCC1_Meng | Human | Liver | HCC | 2.21e-55 | 1.14e-02 | 0.0246 |
51228 | GLTP | HCC2_Meng | Human | Liver | HCC | 3.06e-22 | 6.37e-02 | 0.0107 |
51228 | GLTP | cirrhotic2 | Human | Liver | Cirrhotic | 7.28e-07 | 9.06e-02 | 0.0201 |
51228 | GLTP | HCC1 | Human | Liver | HCC | 4.99e-14 | 3.56e+00 | 0.5336 |
51228 | GLTP | HCC2 | Human | Liver | HCC | 7.04e-38 | 3.65e+00 | 0.5341 |
51228 | GLTP | HCC5 | Human | Liver | HCC | 1.75e-19 | 1.45e+00 | 0.4932 |
51228 | GLTP | Pt13.b | Human | Liver | HCC | 3.69e-05 | 6.25e-02 | 0.0251 |
51228 | GLTP | S014 | Human | Liver | HCC | 9.57e-16 | 6.07e-01 | 0.2254 |
51228 | GLTP | S015 | Human | Liver | HCC | 7.73e-11 | 4.71e-01 | 0.2375 |
51228 | GLTP | S016 | Human | Liver | HCC | 3.72e-19 | 5.85e-01 | 0.2243 |
51228 | GLTP | S027 | Human | Liver | HCC | 1.66e-14 | 9.07e-01 | 0.2446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0042886 | Colorectum | AD | amide transport | 83/3918 | 301/18723 | 3.37e-03 | 2.46e-02 | 83 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00428862 | Colorectum | FAP | amide transport | 62/2622 | 301/18723 | 1.01e-03 | 9.93e-03 | 62 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:0015914 | Colorectum | FAP | phospholipid transport | 23/2622 | 96/18723 | 6.09e-03 | 3.82e-02 | 23 |
GO:00068692 | Colorectum | CRC | lipid transport | 63/2078 | 398/18723 | 2.36e-03 | 2.26e-02 | 63 |
GO:00108763 | Colorectum | CRC | lipid localization | 68/2078 | 448/18723 | 4.60e-03 | 3.58e-02 | 68 |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00066652 | Esophagus | ESCC | sphingolipid metabolic process | 96/8552 | 155/18723 | 3.21e-05 | 2.66e-04 | 96 |
GO:00066642 | Esophagus | ESCC | glycolipid metabolic process | 63/8552 | 100/18723 | 3.55e-04 | 2.06e-03 | 63 |
GO:19035092 | Esophagus | ESCC | liposaccharide metabolic process | 63/8552 | 101/18723 | 5.25e-04 | 2.90e-03 | 63 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:0006643 | Liver | Cirrhotic | membrane lipid metabolic process | 69/4634 | 203/18723 | 1.89e-03 | 1.19e-02 | 69 |
GO:01200091 | Liver | Cirrhotic | intermembrane lipid transfer | 21/4634 | 48/18723 | 3.06e-03 | 1.73e-02 | 21 |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLTP | insertion | Nonsense_Mutation | novel | c.465_466insTAAGAATCTTGGGTTTCGGCAGGGTGCAGTGGCTCACTTCTGTAATC | p.Pro156Ter | p.P156* | Q9NZD2 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
GLTP | insertion | Frame_Shift_Ins | novel | c.597_598insTGTAGTTCCAGCTACTCAGGAGG | p.Gln200CysfsTer10 | p.Q200Cfs*10 | Q9NZD2 | protein_coding | TCGA-B6-A0IB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
GLTP | SNV | Missense_Mutation | rs201181687 | c.607N>A | p.Ala203Thr | p.A203T | Q9NZD2 | protein_coding | tolerated(0.08) | benign(0.344) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GLTP | SNV | Missense_Mutation | rs141894554 | c.397N>A | p.Glu133Lys | p.E133K | Q9NZD2 | protein_coding | tolerated(0.13) | benign(0.048) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GLTP | SNV | Missense_Mutation | novel | c.537N>T | p.Lys179Asn | p.K179N | Q9NZD2 | protein_coding | tolerated(0.22) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GLTP | SNV | Missense_Mutation | novel | c.536N>C | p.Lys179Thr | p.K179T | Q9NZD2 | protein_coding | deleterious(0.02) | benign(0.092) | TCGA-2E-A9G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | CR |
GLTP | SNV | Missense_Mutation | rs758929905 | c.566N>T | p.Ala189Val | p.A189V | Q9NZD2 | protein_coding | tolerated(0.06) | benign(0.027) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GLTP | SNV | Missense_Mutation | novel | c.295N>G | p.Arg99Gly | p.R99G | Q9NZD2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLTP | SNV | Missense_Mutation | c.184A>G | p.Thr62Ala | p.T62A | Q9NZD2 | protein_coding | tolerated(0.06) | benign(0.062) | TCGA-D1-A0ZO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GLTP | SNV | Missense_Mutation | novel | c.473N>G | p.Lys158Arg | p.K158R | Q9NZD2 | protein_coding | tolerated(0.66) | benign(0.005) | TCGA-DI-A1NO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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