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Gene: GLS |
Gene summary for GLS |
Gene summary. |
Gene information | Species | Human | Gene symbol | GLS | Gene ID | 2744 |
Gene name | glutaminase | |
Gene Alias | AAD20 | |
Cytomap | 2q32.2 | |
Gene Type | protein-coding | GO ID | GO:0001967 | UniProtAcc | O94925 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2744 | GLS | P75T-E | Human | Esophagus | ESCC | 2.21e-12 | 3.24e-01 | 0.1125 |
2744 | GLS | P76T-E | Human | Esophagus | ESCC | 1.02e-02 | 1.31e-01 | 0.1207 |
2744 | GLS | P79T-E | Human | Esophagus | ESCC | 1.65e-09 | 1.61e-01 | 0.1154 |
2744 | GLS | P80T-E | Human | Esophagus | ESCC | 3.35e-18 | 3.21e-01 | 0.155 |
2744 | GLS | P82T-E | Human | Esophagus | ESCC | 2.89e-03 | 5.07e-01 | 0.1072 |
2744 | GLS | P83T-E | Human | Esophagus | ESCC | 6.54e-14 | 4.76e-01 | 0.1738 |
2744 | GLS | P84T-E | Human | Esophagus | ESCC | 3.13e-03 | 7.26e-02 | 0.0933 |
2744 | GLS | P89T-E | Human | Esophagus | ESCC | 2.69e-02 | 6.68e-01 | 0.1752 |
2744 | GLS | P91T-E | Human | Esophagus | ESCC | 4.86e-03 | 3.12e-01 | 0.1828 |
2744 | GLS | P104T-E | Human | Esophagus | ESCC | 1.64e-02 | -5.15e-02 | 0.0931 |
2744 | GLS | P107T-E | Human | Esophagus | ESCC | 4.12e-28 | 1.07e+00 | 0.171 |
2744 | GLS | P126T-E | Human | Esophagus | ESCC | 3.18e-05 | 1.47e+00 | 0.1125 |
2744 | GLS | P127T-E | Human | Esophagus | ESCC | 8.17e-13 | -5.69e-02 | 0.0826 |
2744 | GLS | P128T-E | Human | Esophagus | ESCC | 4.46e-16 | 7.48e-01 | 0.1241 |
2744 | GLS | P130T-E | Human | Esophagus | ESCC | 2.05e-63 | 1.68e+00 | 0.1676 |
2744 | GLS | TD9 | Human | Lung | IAC | 4.92e-08 | 1.33e+00 | 0.088 |
2744 | GLS | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 3.98e-07 | 1.24e+00 | -0.1271 |
2744 | GLS | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 4.12e-07 | 1.23e+00 | -0.1406 |
2744 | GLS | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 1.54e-03 | 1.07e+00 | -0.1408 |
2744 | GLS | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 9.38e-04 | 1.10e+00 | -0.138 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:000609114 | Cervix | HSIL_HPV | generation of precursor metabolites and energy | 32/737 | 490/18723 | 3.69e-03 | 3.27e-02 | 32 |
GO:000609124 | Cervix | N_HPV | generation of precursor metabolites and energy | 40/534 | 490/18723 | 2.59e-09 | 7.88e-07 | 40 |
GO:0044282 | Colorectum | AD | small molecule catabolic process | 118/3918 | 376/18723 | 1.05e-06 | 3.55e-05 | 118 |
GO:0016054 | Colorectum | AD | organic acid catabolic process | 73/3918 | 240/18723 | 3.20e-04 | 3.81e-03 | 73 |
GO:0043648 | Colorectum | AD | dicarboxylic acid metabolic process | 34/3918 | 96/18723 | 7.22e-04 | 7.28e-03 | 34 |
GO:0046395 | Colorectum | AD | carboxylic acid catabolic process | 70/3918 | 236/18723 | 9.06e-04 | 8.71e-03 | 70 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:1901605 | Colorectum | MSI-H | alpha-amino acid metabolic process | 26/1319 | 195/18723 | 1.26e-03 | 2.02e-02 | 26 |
GO:0008652 | Colorectum | MSI-H | cellular amino acid biosynthetic process | 13/1319 | 76/18723 | 2.35e-03 | 3.12e-02 | 13 |
GO:1901607 | Colorectum | MSI-H | alpha-amino acid biosynthetic process | 12/1319 | 68/18723 | 2.60e-03 | 3.41e-02 | 12 |
GO:00463941 | Colorectum | MSI-H | carboxylic acid biosynthetic process | 36/1319 | 314/18723 | 2.68e-03 | 3.48e-02 | 36 |
GO:00160531 | Colorectum | MSI-H | organic acid biosynthetic process | 36/1319 | 316/18723 | 2.98e-03 | 3.78e-02 | 36 |
GO:00442823 | Colorectum | FAP | small molecule catabolic process | 77/2622 | 376/18723 | 3.25e-04 | 4.16e-03 | 77 |
GO:00160543 | Colorectum | FAP | organic acid catabolic process | 50/2622 | 240/18723 | 2.30e-03 | 1.85e-02 | 50 |
GO:00436481 | Colorectum | FAP | dicarboxylic acid metabolic process | 24/2622 | 96/18723 | 2.88e-03 | 2.20e-02 | 24 |
GO:00463951 | Colorectum | FAP | carboxylic acid catabolic process | 48/2622 | 236/18723 | 4.53e-03 | 3.08e-02 | 48 |
GO:000609110 | Endometrium | AEH | generation of precursor metabolites and energy | 121/2100 | 490/18723 | 1.65e-17 | 8.23e-15 | 121 |
GO:000609115 | Endometrium | EEC | generation of precursor metabolites and energy | 125/2168 | 490/18723 | 3.76e-18 | 1.88e-15 | 125 |
GO:000609120 | Esophagus | HGIN | generation of precursor metabolites and energy | 145/2587 | 490/18723 | 3.41e-20 | 2.04e-17 | 145 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0523010 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa0523013 | Cervix | CC | Central carbon metabolism in cancer | 18/1267 | 70/8465 | 1.29e-02 | 3.87e-02 | 2.29e-02 | 18 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa04964 | Colorectum | AD | Proximal tubule bicarbonate reclamation | 11/2092 | 23/8465 | 1.35e-02 | 4.86e-02 | 3.10e-02 | 11 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa049641 | Colorectum | AD | Proximal tubule bicarbonate reclamation | 11/2092 | 23/8465 | 1.35e-02 | 4.86e-02 | 3.10e-02 | 11 |
hsa052306 | Colorectum | FAP | Central carbon metabolism in cancer | 23/1404 | 70/8465 | 6.12e-04 | 4.26e-03 | 2.59e-03 | 23 |
hsa052307 | Colorectum | FAP | Central carbon metabolism in cancer | 23/1404 | 70/8465 | 6.12e-04 | 4.26e-03 | 2.59e-03 | 23 |
hsa04724 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
hsa047241 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
hsa0523018 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa0523019 | Esophagus | ESCC | Central carbon metabolism in cancer | 50/4205 | 70/8465 | 1.70e-04 | 6.62e-04 | 3.39e-04 | 50 |
hsa0523016 | Oral cavity | OSCC | Central carbon metabolism in cancer | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
hsa0523017 | Oral cavity | OSCC | Central carbon metabolism in cancer | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
hsa0523041 | Oral cavity | EOLP | Central carbon metabolism in cancer | 17/1218 | 70/8465 | 1.87e-02 | 4.75e-02 | 2.80e-02 | 17 |
hsa0523051 | Oral cavity | EOLP | Central carbon metabolism in cancer | 17/1218 | 70/8465 | 1.87e-02 | 4.75e-02 | 2.80e-02 | 17 |
hsa0523014 | Prostate | BPH | Central carbon metabolism in cancer | 23/1718 | 70/8465 | 9.13e-03 | 2.84e-02 | 1.76e-02 | 23 |
hsa0523015 | Prostate | BPH | Central carbon metabolism in cancer | 23/1718 | 70/8465 | 9.13e-03 | 2.84e-02 | 1.76e-02 | 23 |
hsa00220 | Stomach | GC | Arginine biosynthesis | 6/708 | 22/8465 | 7.81e-03 | 4.10e-02 | 2.88e-02 | 6 |
hsa002201 | Stomach | GC | Arginine biosynthesis | 6/708 | 22/8465 | 7.81e-03 | 4.10e-02 | 2.88e-02 | 6 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLS | SNV | Missense_Mutation | novel | c.603N>C | p.Lys201Asn | p.K201N | O94925 | protein_coding | deleterious(0.01) | possibly_damaging(0.647) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLS | SNV | Missense_Mutation | c.1404N>A | p.Phe468Leu | p.F468L | O94925 | protein_coding | deleterious(0.05) | benign(0.106) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GLS | SNV | Missense_Mutation | novel | c.481N>G | p.Thr161Ala | p.T161A | O94925 | protein_coding | tolerated(0.4) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GLS | SNV | Missense_Mutation | c.1909N>G | p.Lys637Glu | p.K637E | O94925 | protein_coding | tolerated(0.73) | benign(0.01) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GLS | insertion | Frame_Shift_Ins | novel | c.1085dupT | p.Leu362PhefsTer3 | p.L362Ffs*3 | O94925 | protein_coding | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
GLS | SNV | Missense_Mutation | novel | c.1375N>G | p.Leu459Val | p.L459V | O94925 | protein_coding | tolerated(0.06) | possibly_damaging(0.744) | TCGA-2E-A9G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | CR |
GLS | SNV | Missense_Mutation | novel | c.829N>T | p.Asp277Tyr | p.D277Y | O94925 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLS | SNV | Missense_Mutation | c.698N>C | p.Glu233Ala | p.E233A | O94925 | protein_coding | tolerated(0.1) | benign(0.01) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GLS | SNV | Missense_Mutation | c.1016T>G | p.Ile339Ser | p.I339S | O94925 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
GLS | SNV | Missense_Mutation | c.653A>C | p.Lys218Thr | p.K218T | O94925 | protein_coding | deleterious(0.04) | possibly_damaging(0.576) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2744 | GLS | ENZYME | CEFATRIZINE | CEFATRIZINE | ||
2744 | GLS | ENZYME | THUNBERGINOL B | THUNBERGINOL B | ||
2744 | GLS | ENZYME | 2,3,4-TRIHYDROXYBENZOPHENONE | CHEMBL1527 | ||
2744 | GLS | ENZYME | CEFMETAZOLE SODIUM | CEFMETAZOLE SODIUM | ||
2744 | GLS | ENZYME | LINOLENIC ACID | LINOLENIC ACID | ||
2744 | GLS | ENZYME | ANTIANGIOGENIC | 15743040 | ||
2744 | GLS | ENZYME | ASTERRIC ACID | ASTERRIC ACID | ||
2744 | GLS | ENZYME | OXIDOPAMINE HYDROCHLORIDE | OXIDOPAMINE HYDROCHLORIDE | ||
2744 | GLS | ENZYME | ISOTHYMONIN | ISOTHYMONIN | ||
2744 | GLS | ENZYME | DAPHNORIN | DAPHNORIN |
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