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Gene: GLRX |
Gene summary for GLRX |
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Gene information | Species | Human | Gene symbol | GLRX | Gene ID | 2745 |
Gene name | glutaredoxin | |
Gene Alias | GRX | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0002028 | UniProtAcc | A0A024RAM2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2745 | GLRX | LP15 | Human | Oral cavity | LP | 8.53e-05 | 1.27e+00 | 0.2174 |
2745 | GLRX | SYSMH3 | Human | Oral cavity | OSCC | 7.38e-03 | 4.35e-01 | 0.2442 |
2745 | GLRX | SYSMH6 | Human | Oral cavity | OSCC | 3.67e-13 | 6.47e-01 | 0.1275 |
2745 | GLRX | HTA12-23-1 | Human | Pancreas | PDAC | 3.15e-06 | 6.70e-01 | 0.3405 |
2745 | GLRX | HTA12-26-1 | Human | Pancreas | PDAC | 9.73e-10 | 6.45e-01 | 0.3728 |
2745 | GLRX | HTA12-29-1 | Human | Pancreas | PDAC | 6.99e-07 | 3.30e-01 | 0.3722 |
2745 | GLRX | PTCwithoutHT_2 | Human | Thyroid | PTC | 3.26e-06 | -4.28e-01 | 0.0419 |
2745 | GLRX | male-WTA | Human | Thyroid | PTC | 1.01e-18 | -4.08e-01 | 0.1037 |
2745 | GLRX | nodule-WTA | Human | Thyroid | goiters | 3.88e-06 | -4.35e-01 | 0.0534 |
2745 | GLRX | PTC01 | Human | Thyroid | PTC | 3.07e-18 | -3.59e-01 | 0.1899 |
2745 | GLRX | PTC04 | Human | Thyroid | PTC | 1.67e-05 | -1.58e-01 | 0.1927 |
2745 | GLRX | PTC07 | Human | Thyroid | PTC | 2.13e-10 | -1.89e-01 | 0.2044 |
2745 | GLRX | ATC09 | Human | Thyroid | ATC | 8.86e-10 | -9.50e-02 | 0.2871 |
2745 | GLRX | ATC12 | Human | Thyroid | ATC | 9.06e-11 | -2.61e-01 | 0.34 |
2745 | GLRX | ATC13 | Human | Thyroid | ATC | 3.33e-18 | -2.93e-01 | 0.34 |
2745 | GLRX | ATC1 | Human | Thyroid | ATC | 3.00e-08 | -1.08e-01 | 0.2878 |
2745 | GLRX | ATC2 | Human | Thyroid | ATC | 8.56e-06 | 1.98e+00 | 0.34 |
2745 | GLRX | ATC3 | Human | Thyroid | ATC | 1.68e-02 | 4.70e-01 | 0.338 |
2745 | GLRX | ATC5 | Human | Thyroid | ATC | 6.35e-19 | -2.84e-01 | 0.34 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00988698 | Breast | Precancer | cellular oxidant detoxification | 20/1080 | 101/18723 | 1.07e-06 | 4.18e-05 | 20 |
GO:19907488 | Breast | Precancer | cellular detoxification | 21/1080 | 116/18723 | 2.67e-06 | 8.89e-05 | 21 |
GO:00987548 | Breast | Precancer | detoxification | 24/1080 | 152/18723 | 6.49e-06 | 1.81e-04 | 24 |
GO:00972378 | Breast | Precancer | cellular response to toxic substance | 21/1080 | 124/18723 | 7.98e-06 | 2.17e-04 | 21 |
GO:00096368 | Breast | Precancer | response to toxic substance | 31/1080 | 262/18723 | 1.18e-04 | 2.12e-03 | 31 |
GO:00324116 | Breast | Precancer | positive regulation of transporter activity | 16/1080 | 120/18723 | 1.46e-03 | 1.51e-02 | 16 |
GO:00347673 | Breast | Precancer | positive regulation of ion transmembrane transport | 19/1080 | 167/18723 | 3.60e-03 | 2.98e-02 | 19 |
GO:00324143 | Breast | Precancer | positive regulation of ion transmembrane transporter activity | 14/1080 | 109/18723 | 3.97e-03 | 3.15e-02 | 14 |
GO:00109596 | Breast | Precancer | regulation of metal ion transport | 37/1080 | 406/18723 | 4.07e-03 | 3.22e-02 | 37 |
GO:00228985 | Breast | Precancer | regulation of transmembrane transporter activity | 27/1080 | 278/18723 | 5.72e-03 | 4.11e-02 | 27 |
GO:000963613 | Breast | IDC | response to toxic substance | 44/1434 | 262/18723 | 6.33e-07 | 3.00e-05 | 44 |
GO:009875413 | Breast | IDC | detoxification | 29/1434 | 152/18723 | 3.97e-06 | 1.43e-04 | 29 |
GO:009886913 | Breast | IDC | cellular oxidant detoxification | 22/1434 | 101/18723 | 6.31e-06 | 1.98e-04 | 22 |
GO:199074813 | Breast | IDC | cellular detoxification | 23/1434 | 116/18723 | 2.02e-05 | 4.92e-04 | 23 |
GO:009723713 | Breast | IDC | cellular response to toxic substance | 24/1434 | 124/18723 | 2.05e-05 | 4.97e-04 | 24 |
GO:001095913 | Breast | IDC | regulation of metal ion transport | 52/1434 | 406/18723 | 1.76e-04 | 2.97e-03 | 52 |
GO:003241111 | Breast | IDC | positive regulation of transporter activity | 20/1434 | 120/18723 | 7.64e-04 | 9.27e-03 | 20 |
GO:00432703 | Breast | IDC | positive regulation of ion transport | 36/1434 | 275/18723 | 1.11e-03 | 1.22e-02 | 36 |
GO:002289812 | Breast | IDC | regulation of transmembrane transporter activity | 36/1434 | 278/18723 | 1.35e-03 | 1.40e-02 | 36 |
GO:003241411 | Breast | IDC | positive regulation of ion transmembrane transporter activity | 18/1434 | 109/18723 | 1.53e-03 | 1.53e-02 | 18 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLRX | SNV | Missense_Mutation | c.224N>C | p.Ile75Thr | p.I75T | P35754 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
GLRX | SNV | Missense_Mutation | novel | c.170N>G | p.Ile57Ser | p.I57S | P35754 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
GLRX | SNV | Missense_Mutation | rs151319399 | c.292N>T | p.Arg98Trp | p.R98W | P35754 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLRX | SNV | Missense_Mutation | rs140804825 | c.290N>T | p.Thr97Met | p.T97M | P35754 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-A5-A0GB-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLRX | SNV | Missense_Mutation | novel | c.178T>C | p.Tyr60His | p.Y60H | P35754 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD |
GLRX | SNV | Missense_Mutation | novel | c.253G>T | p.Asp85Tyr | p.D85Y | P35754 | protein_coding | deleterious(0.04) | possibly_damaging(0.881) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
GLRX | SNV | Missense_Mutation | c.215N>A | p.Arg72Gln | p.R72Q | P35754 | protein_coding | tolerated(0.12) | possibly_damaging(0.598) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
GLRX | SNV | Missense_Mutation | novel | c.232G>A | p.Asp78Asn | p.D78N | P35754 | protein_coding | tolerated(0.15) | benign(0.165) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
GLRX | SNV | Missense_Mutation | novel | c.134T>G | p.Phe45Cys | p.F45C | P35754 | protein_coding | tolerated(0.08) | benign(0.024) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
GLRX | SNV | Missense_Mutation | c.148G>A | p.Ala50Thr | p.A50T | P35754 | protein_coding | tolerated(0.13) | benign(0.042) | TCGA-CD-A4MG-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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