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Gene: GDI2 |
Gene summary for GDI2 |
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Gene information | Species | Human | Gene symbol | GDI2 | Gene ID | 2665 |
Gene name | GDP dissociation inhibitor 2 | |
Gene Alias | HEL-S-46e | |
Cytomap | 10p15.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P50395 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2665 | GDI2 | P31T-E | Human | Esophagus | ESCC | 6.12e-75 | 1.43e+00 | 0.1251 |
2665 | GDI2 | P32T-E | Human | Esophagus | ESCC | 4.20e-69 | 1.73e+00 | 0.1666 |
2665 | GDI2 | P36T-E | Human | Esophagus | ESCC | 3.19e-19 | 1.11e+00 | 0.1187 |
2665 | GDI2 | P37T-E | Human | Esophagus | ESCC | 6.40e-41 | 1.37e+00 | 0.1371 |
2665 | GDI2 | P38T-E | Human | Esophagus | ESCC | 3.70e-15 | 1.47e+00 | 0.127 |
2665 | GDI2 | P39T-E | Human | Esophagus | ESCC | 4.06e-24 | 6.78e-01 | 0.0894 |
2665 | GDI2 | P40T-E | Human | Esophagus | ESCC | 8.34e-25 | 1.31e+00 | 0.109 |
2665 | GDI2 | P42T-E | Human | Esophagus | ESCC | 6.07e-21 | 1.09e+00 | 0.1175 |
2665 | GDI2 | P44T-E | Human | Esophagus | ESCC | 3.60e-29 | 1.21e+00 | 0.1096 |
2665 | GDI2 | P47T-E | Human | Esophagus | ESCC | 1.58e-26 | 8.07e-01 | 0.1067 |
2665 | GDI2 | P48T-E | Human | Esophagus | ESCC | 2.63e-20 | 6.38e-01 | 0.0959 |
2665 | GDI2 | P49T-E | Human | Esophagus | ESCC | 7.61e-17 | 2.11e+00 | 0.1768 |
2665 | GDI2 | P52T-E | Human | Esophagus | ESCC | 5.55e-28 | 1.24e+00 | 0.1555 |
2665 | GDI2 | P54T-E | Human | Esophagus | ESCC | 3.29e-31 | 1.21e+00 | 0.0975 |
2665 | GDI2 | P56T-E | Human | Esophagus | ESCC | 4.61e-14 | 1.95e+00 | 0.1613 |
2665 | GDI2 | P57T-E | Human | Esophagus | ESCC | 6.47e-27 | 6.79e-01 | 0.0926 |
2665 | GDI2 | P61T-E | Human | Esophagus | ESCC | 1.32e-03 | 1.17e-01 | 0.099 |
2665 | GDI2 | P62T-E | Human | Esophagus | ESCC | 1.31e-45 | 1.10e+00 | 0.1302 |
2665 | GDI2 | P65T-E | Human | Esophagus | ESCC | 5.81e-19 | 6.38e-01 | 0.0978 |
2665 | GDI2 | P74T-E | Human | Esophagus | ESCC | 1.49e-39 | 1.73e+00 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GDI2 | SNV | Missense_Mutation | novel | c.293G>A | p.Arg98His | p.R98H | P50395 | protein_coding | deleterious(0.02) | benign(0.168) | TCGA-AC-A3TN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GDI2 | SNV | Missense_Mutation | rs533312902 | c.868N>T | p.Arg290Trp | p.R290W | P50395 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GDI2 | deletion | Frame_Shift_Del | novel | c.135delT | p.Ile46Ter | p.I46* | P50395 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GDI2 | SNV | Missense_Mutation | novel | c.427N>C | p.Phe143Leu | p.F143L | P50395 | protein_coding | tolerated(0.1) | benign(0.296) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
GDI2 | SNV | Missense_Mutation | novel | c.1243N>A | p.Asp415Asn | p.D415N | P50395 | protein_coding | tolerated(0.29) | benign(0.001) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GDI2 | deletion | Frame_Shift_Del | novel | c.52delN | p.Ile18SerfsTer5 | p.I18Sfs*5 | P50395 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
GDI2 | SNV | Missense_Mutation | c.31N>T | p.Gly11Cys | p.G11C | P50395 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GDI2 | SNV | Missense_Mutation | c.890N>C | p.Val297Ala | p.V297A | P50395 | protein_coding | deleterious(0.02) | possibly_damaging(0.715) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GDI2 | SNV | Missense_Mutation | c.107A>G | p.Asn36Ser | p.N36S | P50395 | protein_coding | deleterious(0.01) | possibly_damaging(0.538) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
GDI2 | SNV | Missense_Mutation | novel | c.865G>T | p.Asp289Tyr | p.D289Y | P50395 | protein_coding | deleterious(0) | possibly_damaging(0.855) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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