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Gene: FAM173A |
Gene summary for FAM173A |
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Gene information | Species | Human | Gene symbol | FAM173A | Gene ID | 65990 |
Gene name | adenine nucleotide translocase lysine methyltransferase | |
Gene Alias | ANT-KMT | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | J3KMW5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65990 | FAM173A | P130T-E | Human | Esophagus | ESCC | 1.23e-79 | 1.53e+00 | 0.1676 |
65990 | FAM173A | S43 | Human | Liver | Cirrhotic | 2.24e-05 | -1.49e-01 | -0.0187 |
65990 | FAM173A | HCC1_Meng | Human | Liver | HCC | 1.18e-77 | 1.50e-01 | 0.0246 |
65990 | FAM173A | HCC2_Meng | Human | Liver | HCC | 9.22e-35 | 2.21e-01 | 0.0107 |
65990 | FAM173A | cirrhotic1 | Human | Liver | Cirrhotic | 2.57e-05 | 1.94e-01 | 0.0202 |
65990 | FAM173A | cirrhotic2 | Human | Liver | Cirrhotic | 3.05e-11 | 2.39e-01 | 0.0201 |
65990 | FAM173A | cirrhotic3 | Human | Liver | Cirrhotic | 1.05e-17 | 2.98e-01 | 0.0215 |
65990 | FAM173A | Pt13.b | Human | Liver | HCC | 1.95e-18 | 2.09e-01 | 0.0251 |
65990 | FAM173A | Pt14.a | Human | Liver | HCC | 2.29e-02 | 1.98e-01 | 0.0169 |
65990 | FAM173A | Pt14.b | Human | Liver | HCC | 5.89e-04 | 1.63e-01 | 0.018 |
65990 | FAM173A | S014 | Human | Liver | HCC | 3.98e-22 | 8.55e-01 | 0.2254 |
65990 | FAM173A | S015 | Human | Liver | HCC | 3.77e-18 | 8.57e-01 | 0.2375 |
65990 | FAM173A | S016 | Human | Liver | HCC | 1.67e-25 | 9.55e-01 | 0.2243 |
65990 | FAM173A | S027 | Human | Liver | HCC | 1.12e-07 | 8.90e-01 | 0.2446 |
65990 | FAM173A | S028 | Human | Liver | HCC | 4.87e-27 | 1.22e+00 | 0.2503 |
65990 | FAM173A | S029 | Human | Liver | HCC | 6.90e-27 | 1.36e+00 | 0.2581 |
65990 | FAM173A | C04 | Human | Oral cavity | OSCC | 1.78e-38 | 1.72e+00 | 0.2633 |
65990 | FAM173A | C21 | Human | Oral cavity | OSCC | 2.17e-60 | 1.90e+00 | 0.2678 |
65990 | FAM173A | C30 | Human | Oral cavity | OSCC | 3.98e-57 | 2.52e+00 | 0.3055 |
65990 | FAM173A | C38 | Human | Oral cavity | OSCC | 3.00e-21 | 1.42e+00 | 0.172 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM173A | SNV | Missense_Mutation | novel | c.705C>A | p.Ser235Arg | p.S235R | Q9BQD7 | protein_coding | tolerated_low_confidence(0.05) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM173A | SNV | Missense_Mutation | rs370792065 | c.658N>A | p.Gly220Arg | p.G220R | Q9BQD7 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM173A | SNV | Missense_Mutation | novel | c.476N>G | p.Asp159Gly | p.D159G | Q9BQD7 | protein_coding | tolerated(0.13) | benign(0) | TCGA-56-7579-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD |
FAM173A | SNV | Missense_Mutation | rs201512651 | c.598N>T | p.Pro200Ser | p.P200S | Q9BQD7 | protein_coding | tolerated(0.44) | benign(0.038) | TCGA-90-A4ED-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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